Does this function exist? peptidyl-arginine C-methyltransferase activity

[pgaudet]

Hi,

GO:0035244 peptidyl-arginine C-methyltransferase activity is defined as 'Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein.' - however all the PRMT enzymes I find transfer to the nitrogen group, see for e. g. this review: https://journals.asm.org/doi/10.1128/EC.00099-07

There is a single annotations by GeneDB to l PRMT6 arginine N-methyltransferase, type I from PMID:20418380 (also annotated to 'histone-arginine N-methyltransferase activity' - I think this annotation is wrong?

@kaxelsen do you know if this activity exists?

Thanks, Pascale

[kaxelsen]

Based on the available evidence (PMID:20418380), Trypanosoma brucei PRMT6 is NOT a C-methyltransferase, but an N-methyltransferase. I have not been able to find (by a simple literature search) any evidence of protein C-methyltransferases.

[pgaudet]

I think I have found evidence for this reaction:

PMID:29743535, PMID:33162960

This modification occurs in anaerobic bacteria.

I'll keep the MF and obsolete the 2 corresponding BPs (single step processes):

• GO:0035245 peptidyl-arginine C-methylation
• GO:0018181 peptidyl-arginine C5-methylation

Thanks, Pascale

[pgaudet]

• change label GO:0035244 -name: peptidyl-arginine C-methyltransferase activity +name: protein-arginine C-methyltransferase activity

to match other terms

[pgaudet]

Dear all,

The proposal has been made to obsolete

• GO:0035245 peptidyl-arginine C-methylation
• GO:0018181 peptidyl-arginine C5-methylation

because these represent molecular functions. There are no annotations to these terms, these terms are not in any subsets. RESID:AA0272 maps to GO:0018181 peptidyl-arginine C5-methylation @nataled.

You can comment on the ticket: https://github.com/geneontology/go-ontology/issues/23704

Thanks, Pascale

[pgaudet]

• add taxon constraint bacteria

[pgaudet]

Added xrefs: EC:2.1.1.379 RHEA:66028