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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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Change labels and definitions 'cellular homeostasis' #24514

Closed pgaudet closed 1 year ago

pgaudet commented 1 year ago

To clarify the usage of these terms, the labels will be changed to 'intracellular x homeostasis' and the definition to 'A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell."

'cellular chemical homeostasis' 'cellular abscisic acid homeostasis' 'cellular acyl-CoA homeostasis' 'cellular amino acid homeostasis' 'cellular arginine homeostasis' 'cellular aspartate homeostasis' 'cellular cysteine homeostasis' 'cellular glutamate homeostasis' 'cellular histidine homeostasis' 'cellular lysine homeostasis' 'cellular ornithine homeostasis' 'cellular threonine homeostasis' 'cellular ammonium homeostasis' 'cellular galactose homeostasis' 'cellular glucose homeostasis' 'cellular response to glucose stimulus' 'cellular monoatomic ion homeostasis' 'cellular monoatomic anion homeostasis' 'cellular monoatomic cation homeostasis' 'cellular nitric oxide homeostasis' 'cellular oxygen homeostasis' 'cellular phosphate ion homeostasis' 'cellular sphingolipid homeostasis' 'cellular sulfate ion homeostasis' 'cellular sulfide ion homeostasis' 'cellular triglyceride homeostasis' 'cellular water homeostasis'

deustp01 commented 1 year ago

Now is probably not the best time to ask, but is there in fact evidence that at least some kinds of cells in some taxa have sensory and regulatory processes in place to detect the abundance of each of these small molecules and to adjust transport and metabolic processes to restore a correct level?

pgaudet commented 1 year ago

I haven't seen anything like this. We can create the terms if needed - in this case 'extracellular x homeostasis' would work, I think.

deustp01 commented 1 year ago

is there in fact evidence

Different issue. What I'm fretting about is whether any cell ever does importing / exporting / sequestering / mobilizing things to ensure that its galactose level is maintained steady within a narrow concentration range. If not, is there such a things as galactose homeostasis? (That's also why I'm not sure this is a good time to raise this issue.)

ukemi commented 1 year ago

Maybe my memory isn't so bad. PMID: 21621292

pgaudet commented 1 year ago

Added the reference to GO:0033502 name: intracellular galactose homeostasis

Thanks both!

pgaudet commented 1 year ago

GO:0030642 cellular sulfate ion homeostasis ==> add reference PMID:24193406