NTR - ATP:inorganic phosphate antiporter activity

[lbreuza]

Please provide as much information as you can:

• Suggested term label: ATP:inorganic phosphate antiporter activity

• ChEBI ID and label of the substance: Please ensure that the ChEBI ID corresponds to the physiological form (pH7.3) of the compound. In the ChEBI entry, pH7.3 compounds have a 'UniProt synonym', as in the example for mycophenolate

• Definition (free text) Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + phosphate(in) = ATP(in) + phosphate(out)

• Reference, in format PMID:####### PubMed=15123600

• Gene product name and ID to be annotated to this term SLC25A23 SLC25A24 SLC25A41

• Parent term(s) GO:0005452 solute:inorganic anion antiporter activity GO:0005347 ATP transmembrane transporter activity

• Synonym(s) (please specify, EXACT, BROAD, NARROW or RELATED) Other than the standard synonyms below

• Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

• Cross-references Rhea:65840

• Any other information

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• FOR ONTOLOGY EDITOR

• Logical definition

• • substance metabolic process: 'metabolic process' and ('has primary input or output' some [substance]
• • substance biosynthetic process: 'biosynthetic process' and ('has primary output' some [substance].
• • substance catabolic process: 'catabolic process' and ('has primary output' some [substance]

• Standard synonyms

• • substance metabolic process:
• • • EXACT: substance metabolism
• • substance biosynthetic process:
• • • EXACT: substance anabolism
• • • EXACT: substance biosynthesis
• • • EXACT: substance formation
• • • EXACT: substance synthesis
• • substance catabolic process:
• • • EXACT: substance breakdown
• • • EXACT: substance catabolism
• • • EXACT: substance degradation

[pgaudet]

+[Term] +id: GO:0140987 +name: ATP:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + inorganic phosphate(in) = ATP(in) + inorganic phosphate(out)." [PMID:15123600] +synonym: "inorganic phosphate:ATP antiporter activity" EXACT [] +xref: RHEA:65840 +intersection_of: GO:0015297 ! antiporter activity +intersection_of: has_primary_input CHEBI:24838 ! inorganic phosphate +intersection_of: has_primary_input CHEBI:30616 ! ATP(4-) +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/24780 xsd:anyURI +created_by: pg +creation_date: 2023-01-26T12:51:22Z

[lbreuza]

It turns out these transporters display broad specificity and we should consider updating these terms to cover this. I am suggesting

adenyl nucleotide:adenyl nucleotide antiporter activity Enables the transfer of adenyl nucleotide from one side of a membrane to the other according to the reaction: adenyl nucleotide(out) + adenyl nucleotide(in) = adenyl nucleotide(in) + adenyl nucleotide(out). [Rhea:72855],[Rhea:73659],[Rhea:73675],[Rhea:73679]
CHEBI:61293-adenyl nucleotide : CHEBI:61293-adenyl nucleotide antiporter activity

adenyl nucleotide:inorganic phosphate antiporter activity Enables the transfer of adenyl nucleotide from one side of a membrane to the other according to the reaction: adenyl nucleotide(out) + inorganic phosphate(in) = adenyl nucleotide(in) + inorganic phosphate(out). [Rhea:65840], [Rhea:65844],[Rhea:70259],[Rhea:72035],[Rhea:73671],[Rhea:73687],[Rhea:73691],[Rhea:73695] CHEBI:61293-adenyl nucleotide: CHEBI:43474-inorganic phosphate antiporter activity