EC:2.3.1.48 is for a general histone acetyltransferase activity (https://enzyme.expasy.org/EC/2.3.1.48), so it's correctly used as the attribution (and xref) on GO:0004402 histone acetyltransferase activity.
But that general EC is also used at the attribution on 20 other more specific histone acetyltransferase GO terms (shown below), which isn't really correct. Can those attributions be replaced with a general GOC reference or the like?
id: GO:0010484
name: histone H3 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [EC:2.3.1.48]
id: GO:0010485
name: histone H4 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48]
id: GO:0032931
name: histone H3K56 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)." [EC:2.3.1.48]
id: GO:0043992
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48]
id: GO:0043993
name: histone H3K18 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [EC:2.3.1.48]
id: GO:0043994
name: histone H3K23 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)." [EC:2.3.1.48]
id: GO:0043995
name: histone H4K5 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]
id: GO:0043996
name: histone H4K8 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)." [EC:2.3.1.48]
id: GO:0043997
name: histone H4K12 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48]
id: GO:0043998
name: histone H2A acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine." [EC:2.3.1.48]
id: GO:0043999
name: histone H2AK5 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]
id: GO:0044012
name: histone H2AK9 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48]
id: GO:0044013
name: histone H2B acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine." [EC:2.3.1.48]
id: GO:0044014
name: histone H2BK5 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]
id: GO:0044015
name: histone H2BK12 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48]
id: GO:0044016
name: histone H3K4 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)." [EC:2.3.1.48]
id: GO:0044017
name: histone H3K27 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [EC:2.3.1.48]
id: GO:0044018
name: histone H3K36 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)." [EC:2.3.1.48]
id: GO:0044019
name: histone H3K72 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)." [EC:2.3.1.48]
id: GO:0046972
name: histone H4K16 acetyltransferase activity
def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4." [EC:2.3.1.48]
sjm41
commented
3 months ago
EC:2.3.1.48 is for a general histone acetyltransferase activity (https://enzyme.expasy.org/EC/2.3.1.48), so it's correctly used as the attribution (and xref) on GO:0004402 histone acetyltransferase activity.
But that general EC is also used at the attribution on 20 other more specific histone acetyltransferase GO terms (shown below), which isn't really correct. Can those attributions be replaced with a general GOC reference or the like?
id: GO:0010484 name: histone H3 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [EC:2.3.1.48]
id: GO:0010485 name: histone H4 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48]
id: GO:0032931 name: histone H3K56 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)." [EC:2.3.1.48]
id: GO:0043992 def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48]
id: GO:0043993 name: histone H3K18 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [EC:2.3.1.48]
id: GO:0043994 name: histone H3K23 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)." [EC:2.3.1.48]
id: GO:0043995 name: histone H4K5 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]
id: GO:0043996 name: histone H4K8 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)." [EC:2.3.1.48]
id: GO:0043997 name: histone H4K12 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48]
id: GO:0043998 name: histone H2A acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine." [EC:2.3.1.48]
id: GO:0043999 name: histone H2AK5 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]
id: GO:0044012 name: histone H2AK9 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48]
id: GO:0044013 name: histone H2B acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine." [EC:2.3.1.48]
id: GO:0044014 name: histone H2BK5 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]
id: GO:0044015 name: histone H2BK12 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48]
id: GO:0044016 name: histone H3K4 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)." [EC:2.3.1.48]
id: GO:0044017 name: histone H3K27 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [EC:2.3.1.48]
id: GO:0044018 name: histone H3K36 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)." [EC:2.3.1.48]
id: GO:0044019 name: histone H3K72 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)." [EC:2.3.1.48]
id: GO:0046972 name: histone H4K16 acetyltransferase activity def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4." [EC:2.3.1.48]