NTR: transforming growth factor beta receptor superfamily signaling pathway

[vanaukenk]

Please provide as much information as you can:

• Suggested term label:

transforming growth factor beta receptor superfamily signaling pathway

• Definition (free text)

The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription.

• Reference, in format PMID:#######

PMID: 28096268 PMID: 22651914

• Gene product name and ID to be annotated to this term

This will be used to annotate some C. elegans genes, e.g. daf-1, a Type I receptor, that participate in signaling pathways that don't necessarily neatly map on to one of the existing subclasses of TGFbeta superfamily signaling, i.e. activin, BMP, or TGFbeta.

• Parent term(s)

GO:0007178. transmembrane receptor protein serine/threonine kinase signaling pathway

• Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

activin receptor signaling pathway (GO:0032924) BMP receptor signaling pathway (GO:0030509) transforming growth factor beta receptor signaling pathway (GO:0007179)

• Synonyms (please specify, EXACT, BROAD, NARROW or RELATED)

• Cross-references

• For enzymes, please provide RHEA and/or EC numbers.

• Can also provide MetaCyc, KEGG, Wikipedia, and other links.

• Any other information

Please also see: https://github.com/geneontology/go-ontology/issues/23449

[pgaudet]

Done in #23449 but I am not sure about taxon constraints

see also https://github.com/geneontology/go-annotation/issues/4231

@vanaukenk @hattrill @Antonialock @ValWood

[pgaudet]

+[Term] +id: GO:0141091 +name: transforming growth factor beta receptor superfamily signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by an extracellular ligand binding to a member of the transforming growth factor receptor superfamily, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:22651914, PMID:28096268] +synonym: "TGF-beta receptor superfamily signaling pathway" EXACT [] +synonym: "TGF-beta receptor superfamily signalling pathway" EXACT [] +synonym: "TGFbeta receptor superfamily signaling pathway" EXACT [] +synonym: "TGFbeta receptor superfamily signalling pathway" EXACT [] +synonym: "transforming growth factor beta receptor superfamily signalling pathway" EXACT [] +is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway +created_by: pg +creation_date: 2023-08-30T05:48:29Z

[ValWood]

perhaps "only in metazoa"? (at least never in fungi ?)