GO:0000836 Hrd1p ubiquitin ligase complex

[ValWood]

Aren't these saying the same thing:

GO:0000836 Hrd1p ubiquitin ligase complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78). PMID:16619026 PMID:16873066 PMID:21454652

and

GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. PMID:16873065 PMID:16873066

[pgaudet]

I dont know,

• Hrd1p is parent of Hrd1p ubiquitin ligase ERAD-L and Hrd1p ubiquitin ligase ERAD-M complexes
• So the 3 would have the be the same thing ?
• In cases like this one I find that the grouping term brings more confusion than clarification.

[ValWood]

PMID: 32327568 Misfolded luminal endoplasmic reticulum (ER) proteins undergo ER-associated degradation (ERAD-L): they are retro-translocated into the cytosol, poly-ubiquitinated, and degraded by the proteasome. ERAD-L is mediated by the Hrd1 complex (composed of Hrd1, Hrd3, Der1, Usa1, and Yos9), but the mechanism of retro-translocation remains mysterious. Here, we report a structure of the active Hrd1 complex, as determined by cryo-EM analysis of two sub-complexes. Hrd3 and Yos9 jointly create a luminal binding site that recognizes glycosylated substrates. Hrd1 and the rhomboid-like Der1 protein form two “half-channels” with cytosolic and luminal cavities, respectively, and lateral gates facing one another in a thinned membrane region. Together with crosslinking and molecular dynamics simulation results, the structures suggest how a polypeptide loop of an ERAD-L substrate moves through the ER membrane.

PMID: 25100021 Finally, membrane proteins with a misfolded region in their transmembrane domain(s) are also targeted to the Hrd1-complex. However, in this case, fewer associated components are required for the degradation of these substrates; this pathway was termed ERAD-M (M for membrane) [14,15,16]. PMID: 25100021

ERAD-L and ERAD-M appear to be different pathways enabled by Hrd1-compex

I have a ticket to look a the pathways and complexes for GO-CAM but this will be a long way off https://github.com/pombase/curation/issues/3545