NTR: ligand-activated transcription repressor activity

[pgaudet]

Please provide as much information as you can:

• Suggested term label: ligand-activated transcription repressor activity

• Definition (free text)

• Reference, in format PMID:####### PMID:21555518

• Gene product name and ID to be annotated to this term O14867 BACH1

• Parent term(s) 'DNA-binding transcription repressor activity' ligand-activated transcription factor activity

• Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

• Synonyms (please specify, EXACT, BROAD, NARROW or RELATED)

• Cross-references

• For enzymes, please provide RHEA and/or EC numbers.

• Can also provide MetaCyc, KEGG, Wikipedia, and other links.

• Any other information

[pgaudet]

+[Term] +id: GO:0141096 +name: ligand-activated transcription repressor activity +namespace: molecular_function +def: "A DNA-binding transcription repressor activity regulated by binding to a ligand and that inhibits the transcription of specific genes and gene sets." [PMID:21555518] +is_a: GO:0001217 ! DNA-binding transcription repressor activity +is_a: GO:0098531 ! ligand-activated transcription factor activity +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26077" xsd:anyURI +created_by: pg +creation_date: 2023-09-11T08:07:51Z

[pgaudet]

+[Term] +id: GO:0141097 +name: ligand-activated transcription activator activity +namespace: molecular_function +def: "A DNA-binding transcription activator activity regulated by binding to a ligand and that activates the transcription of specific genes and gene sets." [GOC:pg] +is_a: GO:0001216 ! DNA-binding transcription activator activity +is_a: GO:0098531 ! ligand-activated transcription factor activity +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/26077" xsd:anyURI +created_by: pg +creation_date: 2023-09-11T08:11:03Z +

[ValWood]

Aren't all gene-specific transcription activators going to be ligand-activated in some way?

[pgaudet]

are they?

[ValWood]

I don't know but the TFs need to be activated to repress by something? I guess it depends how the "ligand" is defined?