Closed lbreuza closed 6 months ago
PMID: 26359318 says "CD27 belongs to the tumor necrosis factor (TNF) receptor family". Would this existing term suffice? GO:0033209 tumor necrosis factor-mediated signaling pathway.
No, the tumor necrosis factor receptor superfamily (TNFRSF) is a large family of structurally similar proteins, for which the tumor necrosis factor receptor signaling pathway is just a prototype that is activated by a particular protein known as tumor necrosis factor (which itself is a member of a superfamily). It would be a misrepresentation of the biology to conflate the CD27 signaling pathway with the TNF signaling pathway, because there are completely separate receptor ligand pairs expressed in different cell types with different biological outcomes.
+[Term] +id: GO:0160162 +name: CD27 signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by the binding of the cell surface receptor CD27 to its physiological ligand CD70, and ending with the regulation of a downstream cellular process, e.g. transcription." [PMID:26359318, PMID:8387892] +is_a: GO:0007166 ! cell surface receptor signaling pathway +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/27080" xsd:anyURI +created_by: rynl +creation_date: 2024-02-21T21:43:14Z
Please provide as much information as you can:
Suggested term label: CD27 signaling pathway
Definition (free text) The series of molecular signals initiated by the binding of the cell surface receptor CD27 to its physiological ligand CD70, and ending with the regulation of a downstream cellular process, e.g. transcription.
Reference, in format PMID:####### (REQUIRED) PubMed:8387892, PMID: 26359318
Gene product name and ID to be annotated to this term CD27, CD70...
Parent term(s) GO:0007166 cell surface receptor signaling pathway
Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?
Synonyms (please specify, EXACT, BROAD, NARROW or RELATED)
Cross-references
For enzymes, please provide RHEA and/or EC numbers.
Can also provide MetaCyc, KEGG, Wikipedia, and other links.
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