NTR: positive regulation of reactive nitrogen species metabolic process

[RLovering]

Please provide as much information as you can:

• Suggested term label: positive regulation of reactive nitrogen species metabolic process

• Definition (free text) Any process that activates or increases the frequency, rate or extent of reactive nitrogen species metabolic process

• **Reference, in format PMID:7715705

• Gene product name and ID to be annotated to this term UniProtKB:P01579 | IFNG MGI:MGI:104798 | Tnf MGI:MGI:107656 | Ifng

• Parent term(s)

• GO:2001057 reactive nitrogen species metabolic process

• Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

• GO:1904407 positive regulation of nitric oxide metabolic process

• Synonyms (please specify, EXACT, BROAD, NARROW or RELATED)

• Cross-references

• For enzymes, please provide RHEA and/or EC numbers.

• Can also provide MetaCyc, KEGG, Wikipedia, and other links.

• Any other information

• Required for more specific annotation of positive regulation of nitrogen compound metabolic process https://github.com/geneontology/go-annotation/issues/5148

• Also

• Ideally there would be terms for nitrite metabolism as well ie:

• GO:2001057 reactive nitrogen species metabolic process

• is a child: nitrite metabolic process

• is a positive regulation child: positive regulation of nitrite metabolic process

BTW I am not sure that nitrate is a reactive nitrogen?

[pgaudet]

Ha ! Thanks for the clarification.

We do have GO:1903428 positive regulation of reactive oxygen species biosynthetic process ; it sounds like you would like to distinguish nitrogen species. I can create a child; what would be the siblings ? I know there is also H2O2 and many others. We could at least have a few common ones, if there are different pathways generating the different ROS.

Also - I would not use 'metabolic process'. Another point is @genegodbold and I have look at the symbiont response to this process, and we ended up renaming the term 'ROS generation', which seems closer to what we fing in the literature.

Thanks, Pascale