Open Timothy-Ta opened 7 months ago
I was thinking about this today in the context of single-step processes. Some virions are enveloped by budding internal to the cell, or by budding through a host membrane into the cellular exterior. There are usually multiple proteins involved in the membrane bending. Sometimes more than one acquisition and loss of the envelope occurs during the virion maturation (see GO:0046745 viral capsid secondary envelopment which applies to herpesviruses). Under the broader term assembly, envelopment is only one step of the process.
@jrr-cpt Are you saying that this should be annotated as part of virion assembly?
Please provide as much information as you can:
Suggested term label: virion envelopment
Definition : The process in which a virion acquires an envelope from the host cell.
**Reference, in format PMID: 874459, 4431085, 798023, 22379079 (REQUIRED) - these four papers demonstrate phi6 is enveloped inside the cell and that specific phi6 proteins mediate the envelopment.
Gene product name and ID to be annotated to this term Major envelope protein P07581
Parent term(s) GO:0019068 virion assembly
Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term? NONE
Synonyms (please specify, EXACT, BROAD, NARROW or RELATED) Envelope Acquisition : EXACT Primary Envelopment : NARROW
Cross-references NONE
Any other information GO:0046745 viral capsid secondary envelopment
This process also occurs de novo for poxviruses, references can be provided if requested.
Additionally, virion envelopment occurs for plasmaviruses (bacteriophages) but no capsid is involved. This is for the CACAO class @jrr-cpt , and @dsiegele