pgaudet
commented
2 months ago Dear all,
The proposal has been made to obsolete GO:0036132 (5 EXP annotations: human PTGR1 and orthologs) name: 13-prostaglandin reductase activity & replace by GO:0047522 (1 EXP annotation: human PTGR2) name: 15-oxoprostaglandin 13-oxidase activity. The reason for obsoletion is that these represent the same reaction, in opposite direction. Both terms share the same EC.
RHEA mappings (missing) will be added: RHEA:11912 and RHEA:11916 that describe two related substrates.
You can comment on the ticket: https://github.com/geneontology/go-ontology/issues/28134
Thanks, Pascale
EC and KEGG xrefs on these 2 terms are the same. Comment on both says: Note that this is the reverse of the reaction described in '15-oxoprostaglandin 13-oxidase activity ; GO:0047522'.
@pgaudet Do you see a good reason to keep both, or should we merge?
id: GO:0036132 (5 EXP annotations: human PTGR1 and orthologs) name: 13-prostaglandin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG_REACTION:R04556, KEGG_REACTION:R04557, PMID:17449869] comment: Note that this is the reverse of the reaction described in '15-oxoprostaglandin 13-oxidase activity ; GO:0047522'. synonym: "15-ketoprostaglandin delta13-reductase activity" RELATED [EC:1.3.1.48] synonym: "15-oxo-delta13-prostaglandin reductase activity" RELATED [EC:1.3.1.48] synonym: "15-oxoprostaglandin 13-reductase activity" EXACT [] synonym: "delta13-15-ketoprostaglandin reductase activity" RELATED [EC:1.3.1.48] synonym: "prostaglandin 13-reductase activity" RELATED [EC:1.3.1.48] synonym: "prostaglandin delta13-reductase activity" RELATED [EC:1.3.1.48] xref: EC:1.3.1.48 xref: KEGG_REACTION:R04556 xref: KEGG_REACTION:R04557 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
id: GO:0047522 (1 EXP annotation: human PTGR2) name: 15-oxoprostaglandin 13-oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG_REACTION:R04556, KEGG_REACTION:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN] comment: Note that this is the reverse of the reaction described in '13-prostaglandin reductase activity ; GO:0036132'. synonym: "(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity" RELATED [EC:1.3.1.48] xref: EC:1.3.1.48 xref: KEGG_REACTION:R04556 xref: KEGG_REACTION:R04557 xref: MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
EC:1.3.1.48 is: Name: 15-oxoprostaglandin 13-reductase AKA: 15-oxo-Delta(13)-prostaglandin reductase, prostaglandin 13-reductase Reactions: 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxoprostaglandin E2 + H(+) + NADPH 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) <=> 15-oxoprostaglandin E2 + H(+) + NADH
mapped to RHEA:11912 and RHEA:11916