Missing parent: propose "GONEW ferric iron reductase"

[ValWood]

• GO term ID and label for which you request a new superclass

I have been asked by a user for all of the ferric iron reductases. I imagined this would be a simple query but it seems we do not have such a term.

The best I can find is

https://www.pombase.org/term/GO:0016722 oxidoreductase activity, acting on metal ions (GO:0016722)

• New superclass (parent) suggested

GONEW: ferric iron reductase Would not be a child of "oxidoreductase activity, acting on metal ions (" because some of these don't act on ions?

Although,

Q1 .....are all of the existing children acting on ions? is Fe-chelate still classed as an ion? Q2 why is [[methionine synthase] reductase (NADPH) activity] (GO:0030586) is_a oxidoreductase activity, acting on metal ions (GO:0016722) Q3 Should NADPH-hemoprotein reductase activity (GO:0003958) go under such a term? It is [Fe(III)-heme b]? Q4 Should ferredoxin-NAD+ reductase activity go under such a term? Q5 Are there any other ferric oxidoreductase reductases?

• Reference(s), if appropriate PMID:nnnnnnn

[pgaudet]

Could they be moved under ferric-chelate reductase activity?

Assuming that these are the terms you are trying to group:

'ferric-chelate reductase (NADH) activity' http://purl.obolibrary.org/obo/GO_0140618 'ferric-chelate reductase (NADH) activity' http://purl.obolibrary.org/obo/GO_0140618 'ferric-chelate reductase (NADPH) activity' http://purl.obolibrary.org/obo/GO_0052851 'ferric-chelate reductase (NADPH) activity' http://purl.obolibrary.org/obo/GO_0052851 'diferric-transferrin reductase (NAD+) activity' http://purl.obolibrary.org/obo/GO_0047852 'diferric-transferrin reductase (NAD+) activity' http://purl.obolibrary.org/obo/GO_0047852

[ValWood]

but ferroxidase activity (GO:0004322) is a ferric iron reductase, but not a ferric-chelate reductase activity

[pgaudet]

which terms are you trying to group? when I search the ontology for 'ferric iron reductase' these are the results I got.

[ValWood]

https://www.pombase.org/term/GO:0052851 and https://www.pombase.org/term/GO:0004322

are both ferric iron reductases.

[ValWood]

I also have a note from another user that frp1 which I have currently annoted to

GO:0052851 | ferric-chelate reductase (NADPH) activity

is nothing to do with the siderophore system "Concerning your questions, as far as know, there are no papers reporting any functional roles for Frp1 and Frp2 with respect to siderophore (ferrichrome) uptake in S pombe."

"With respect to high affinity Fe uptake via Fio1/Frp1 machinery, it is known (based on S cerevisiae data) that Frp1 plays a crucial role for reducing Fe3+ to Fe2+ prior its passage across the membrane through Fio1/Frp1 heterocomplex. We know that Frp1 has a huge ferrireductase activity at the cell surface."

so I need the new term to move this up to (or even a more specific term?

[ValWood]

"fungi has siderophore and non-siderophore-associated ferric reductases. While many fungi produce siderophores to acquire iron from their environment, they also possess ferric reductases that operate independently of siderophores. These enzymes are typically involved in the direct reduction of ferric iron (Fe³⁺) to ferrous iron (Fe²⁺) on the cell surface, facilitating iron uptake without the need for siderophore-mediated mechanisms." so I need

Fe3+ +NAD(P)H +H + → Fe2+ +NAD(P)+