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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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Query: difference between chaperone terms #28445

Open RLovering opened 3 months ago

RLovering commented 3 months ago

Hi

please could someone explain the difference between these two terms and then improve the definitions so that it is easier to choose which one to use: GO:0140318 protein transporter activity Molecular Function Definition: Directly binding to a specific protein and delivering it to a specific cellular location. PMID:18706423
Synonym		 Type
protein transport chaperone related
protein carrier activity related

GO:0140597 protein carrier chaperone Molecular Function Definition: Binding to and carrying a protein between two different cellular components by moving along with the target protein. PMID:7628437

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Synonym Type protein carrier activity exact protein chaperone broad

Thanks

Ruth

ValWood commented 3 months ago

The definition of "carrier" chaperone is a bit strange considering its child terms? I wouldn't say histone chaperones were "carrying a protein between two different cellular components". They are preventing the histone from being lost from a location and making inappropriate interactions.

pgaudet commented 3 months ago

I agree this is not very clear. Actually I had proposed to obsolete 'GO:0008565 protein transporter activity' but it seems I didn't :
https://github.com/geneontology/go-ontology/issues/17071

This is the ticket where I created GO:0140318 protein carrier activity https://github.com/geneontology/go-ontology/issues/28445

In a way protein transporter activity serves as a useful (?) grouping term but then we should move GO:0140597 protein carrier chaperone under it?

Thanks, Pascale

ValWood commented 3 months ago

We can't move protein carrier under "protein transporter activity" because histone chaperone is not a transporter. Probably the main issue is that chaperones and carriers are conflated?

Histone chaperones should be defined along the lines: proteins that assist in the assembly, disassembly, and exchange of histones on DNA.

and this would apply to many assembly/dissassembly chaperones?

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