regulation of myelination and children

[gocentral]

One of our curators was annotating a gene product that appearts to be involved in the regulation of myelination but the only term in GO was myelination.

PMID: 15139015

Proposed term: GO:0042552 - myelination GO:new regulation of myelination GO:new negative regulation of myelination GO:new positive regulation of myelination

Definition - regulation of myelination Any process that modulates the frequency, rate or extent of myelination, the process by which the myelin sheath around the axons of neurons in the peripheral and central nervous system is acquired, developed or formed.

Definition: negative regulation of myelination Any process that stops, prevents or reduces the rate of myelination.

Definition: positive regulation of myelination Any process that activates or increases the rate

Thanks,

Victoria

Reported by: vpetri

Original Ticket: "geneontology/ontology-requests/2879":https://sourceforge.net/p/geneontology/ontology-requests/2879

[gocentral]

Logged In: YES user_id=835115

Seems reasonable to me. However, be sure that your new terms do not introduce a conflic with the existing term GO:0043217 'myelin maintenance'.

For example, if a mutation causes a reduction in the amount of compact myelin, would that gene be annotated to 'myelin maintenance' or perhpas 'negative regulation of myelination'?

-Doug

Original comment by: doughowe

[gocentral]

Logged In: YES user_id=898310

I didn't see the term for maintenance of myelination. However I think that myelination - the process of forming the compact myelin, and myelin mainenance - the process of maintaining the strcuture/function of mature myelin, the result of myelination are distinct terms.

I see forming (and its regulation) and maintenance of what has been formed (and its regulation) as being distinct terms that may engage (or not) different proteins.

In your example, it depends on whether the mutation causes a). a decrease in the amount of myelin expected to be formed GO term - myelination or b). a decrease in the amount of existemt myelin - GO term myelin maintenance

In neither case do I see a call for regulatory terms. Regulation would appply to those gene products that 'regulate' the activity of proteins involved in myelination or in its maintenance (no terms for that). Depnding on conditions and demands the direction of regulation could be positive or negative.

Does it make sense?

Original comment by: vpetri

[gocentral]

Logged In: YES user_id=436423

I've added the terms: regulation of myelination GO:0031641 negative regulation of myelination GO:0031642 positive regulation of myelination GO:0031643

... with definitions that emphasize formation of myelin, to help distinguish from myelin maintenance.

also added some terms to come a bit closer to complete parentage: regulation of neurophysiological process GO:0031644 negative regulation of neurophysiological process GO:0031645 positive regulation of neurophysiological process GO:0031646

I think if all you have is a mutant phenotype, you wouldn't know whether myelination or myelin maintenance is the best term to use for annotation -- but that's a limitation of mutant phenotype data ... you might have to use the parent 'cellular nerve ensheathment' (GO:0042553).

Original comment by: mah11

[gocentral]

• milestone: --> Plant Ontology
• assigned_to: nobody --> gomidori
• status: open --> closed-accepted

Original comment by: mah11

[gocentral]

• Group: Plant Ontology --> None

Original comment by: cooperl09