glial cell differentaition new children terms

[gocentral]

Annotatiosn for a gene product required the terms regulation of myelination (already requested) and of oligodendrocyte differentiation

PMID: 15139015

Astrocytes and oligodendrocytes are types of glial (neuroglia) cells that are involved in providing support and nutrition, maintaining homeostasis and participating in signal transduction (the former) and in myelinating the axons of neurons in the CNS (the latter).

GO only has astrocye activation and nothing on oligodendrocyte

Proposed new terms GO:0010001 - glial cell differentiation GO:new - astrocyte differentaition GO:new - oligodendrocyte differentiation GO:0045685 - regulation of glial cell differentiation GO:new - regulation of astrocyte differentiation GO:new - regulation of oligodendrocye differentiation GO:0045686 - negative regulation of glial cell differentiation GO:new - negative regulation of astrocyte differentiation GO:new - negative regulation of oligodendrocyte differentiation GO:0045687 - positive regulation of glial cell differentiation GO:new - positive regulation of astrocyte differentiation GO:new positive regulation of oligodendrocyte differentiation

Definitions for the new terms. GO:new- astrocyte differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte, the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. GO:new - oligodendrocyte differentaition The process whereby a relatively unspecialized cell acquires the specialized features of an oligodendrocye, a type of glial cell involved in myelinating the axons of neurons in the central nervous system. GO:new - regulation of astrocyte differentiation Any process that modulates the frequency, rate or extent of astrocyte differentiation GO:new - regulation of oligodendrocyte differentiation Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation GO:new - negative regulation of astrocyte differentiation Any process that stops, prevents or reduces the rate of astrocyte differentiation GO:new - negative regulation of oligodendrocyte differentiation Ahy process that stops, prevents or reduces the rate of oligodendrocyte differentiation GO:new - positive regulation of astrocyte differentiation Any process that activates or increases the rate of astrocyte differentiation GO:new - positive regulation of oligodendrocyte differentaition Any process that activates or increases the rate of oligodendrocyte differentaition

Thanks,

Victoria

Reported by: vpetri

Original Ticket: "geneontology/ontology-requests/2882":https://sourceforge.net/p/geneontology/ontology-requests/2882

[gocentral]

• assigned_to: nobody --> jenclark

Original comment by: jenclark

[gocentral]

Logged In: YES user_id=735846

Thanks Victoria,

Here are the new terms:

id: GO:0048708 name: astrocyte differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [RGD:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation

[Term] id: GO:0048709 name: oligodendrocyte differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. " [RGD:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation

[Term] id: GO:0048710 name: regulation of astrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency\, rate or extent of astrocyte differentiation." [RGD:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation relationship: part_of GO:0048708 ! astrocyte differentiation

[Term] id: GO:0048711 name: positive regulation of astrocyte differentiation namespace: biological_process def: "Any process that activates or increases the rate of astrocyte differentiation." [RGD:vp, PMID:15139015] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation

[Term] id: GO:0048712 name: negative regulation of astrocyte differentiation namespace: biological_process def: "Any process that stops\, prevents or reduces the rate of astrocyte differentiation." [RGD:vp, PMID:15139015] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation

[Term] id: GO:0048713 name: regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency\, rate or extent of oligodendrocyte differentiation." [RGD:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation relationship: part_of GO:0048709 ! oligodendrocyte differentiation

[Term] id: GO:0048714 name: positive regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that activates or increases the rate of oligodendrocyte differentiation." [RGD:vp, PMID:15139015] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation

[Term] id: GO:0048715 name: negative regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that stops\, prevents or reduces the rate of oligodendrocyte differentiation." [RGD:vp, PMID:15139015] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation

Jen

Original comment by: jenclark

[gocentral]

• milestone: --> Plant Ontology
• status: open --> closed-accepted

Original comment by: jenclark

[gocentral]

• assigned_to: Jennifer Deegan --> nobody
• Group: Plant Ontology --> None

Original comment by: cooperl09