geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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Terms with 2 RHEAs as definition xref #28938

Closed pgaudet closed 23 hours ago

pgaudet commented 2 days ago
GOID | Label & def | RHEA 1 | RHEA 2 |  change -- | -- | -- | -- | -- GO:0003984 | **acetolactate synthase activity** Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2, or 2-oxobutanoate + H+ + pyruvate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2. [ | RHEA:25249 | RHEA:27654 |  Change def xref from 2 RHEA to the single EC GO:0004160 | **dihydroxy-acid dehydratase activity** Catalysis of the reaction: (2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O, or (2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O. [ | RHEA:24809 | RHEA:27694 |  GO:0010945 | **coenzyme A diphosphatase activity** Catalysis of the reaction: an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. This reaction can also use coenzyme A as a substrate. [PMID:10922370, PMID:16185196, | RHEA:50044 | RHEA:64988 | Remove the 2 narrowRHEA from defxref; add EC:3.6.1.77 as narrow xref; GO is broader than either GO or EC. The def xef should probably be replaced by the EC.
pgaudet commented 1 day ago

EMailed Rhea helpdesk

I wonder why RHEA:27694 is associated with EC:4.2.1.9 dihydroxy-acid dehydratase, which only mentions 2,3-dihydroxy-3-methylbutanoate , but NOT 2,3-dihydroxy-3-methylpentanoate.

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