geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
Creative Commons Attribution 4.0 International
223 stars 40 forks source link

GO:0030641 regulation of cellular pH #29164

Open ValWood opened 3 weeks ago

ValWood commented 3 weeks ago

GO:0030641 regulation of cellular pH is defined as Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.

which sounds more like "ph homeostasis"

should the term labels switch ? (see synonyms)

cmungall commented 2 weeks ago

Maybe we can simplify this:

image

I excluded regulation edges to make it more tractable but if we include we see 2nd order regulation...:

image
pgaudet commented 2 weeks ago

Fixed LD for regulation of intracellular pH

-intersection_of: regulates_characteristic OBA:0000050 >> obsolete +intersection_of: regulates_characteristic OBA:0000058 ! cellular pH

smoe commented 6 days ago

Hello, homeostasis I understand as the goal of the regulation, like an ideal state, not the regulation as a process to achieve it.

raymond91125 commented 6 days ago

In GO, "homeostasis" is a shorthand for homeostatic process GO:0042592 Any biological process involved in the maintenance of an internal steady state.

raymond91125 commented 6 days ago

To simplify, I think it's necessary to

  1. clarify what the difference is, if any, between "regulation of X" from "homeostatic regulation (homeostasis) of X".
  2. decide if it makes sense to have child processes like elevation, reduction, reneuralization, which can be separately regulated.
pgaudet commented 1 day ago

Discussion on the ontology editors call: