Refresh Reactome imports.

[balhoff]

For #29249.

I thought this was being refreshed when the ontology was built in the pipeline, however when I run it locally the xref to the obsolete term does not appear. Hopefully this will unstick things, but I think the workflow here needs a little more investigation.

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Here's a diff of how these changes impact the classified ontology:

Ontology comparison

Left

• Ontology IRI: http://purl.obolibrary.org/obo/go.owl
• Version IRI: http://purl.obolibrary.org/obo/go/releases/2024-11-19/go.owl
• Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/../../reasoned-master.owl/reasoned.owl

Right

• Ontology IRI: http://purl.obolibrary.org/obo/go.owl
• Version IRI: http://purl.obolibrary.org/obo/go/releases/2024-11-19/go.owl
• Loaded from: file:/__w/go-ontology/go-ontology/src/ontology/../../reasoned-pr.owl/reasoned.owl

Ontology imports

Ontology annotations

1-phosphatidylinositol-3-kinase activity http://purl.obolibrary.org/obo/GO_0016303

Removed

• 1-phosphatidylinositol-3-kinase activity database_cross_reference "Reactome:R-HSA-9028519"
  • label "NTRK2-activated PI3K generates PIP3"

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity http://purl.obolibrary.org/obo/GO_0046934

Removed

• 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity database_cross_reference "Reactome:R-HSA-1839107"
  • label "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3."

Added

• 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity database_cross_reference "Reactome:R-HSA-9860816"

  • label "Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate"

• 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity database_cross_reference "Reactome:R-HSA-1839107"

  • label "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3"

• 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity database_cross_reference "Reactome:R-HSA-9028519"

  • label "NTRK2-activated PI3K generates PIP3"

15-oxoprostaglandin 13-oxidase [NAD(P)+] activity http://purl.obolibrary.org/obo/GO_0047522

Added

• 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity database_cross_reference "Reactome:R-HSA-2161692"
  • label "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1"

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity http://purl.obolibrary.org/obo/GO_0008425

Added

• 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity database_cross_reference "Reactome:R-HSA-2162188"
  • label "COQ5 methylates MDMQ10H2"

3',5'-cyclic-AMP phosphodiesterase activity http://purl.obolibrary.org/obo/GO_0004115

Added

• 3',5'-cyclic-AMP phosphodiesterase activity database_cross_reference "Reactome:R-HSA-9865748"
  • label "PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP"

3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0010420

Added

• 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity database_cross_reference "Reactome:R-HSA-2162193"
  • label "COQ3 methylates DHDB"

3-demethylubiquinol-n 3-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0061542

Added

• 3-demethylubiquinol-n 3-O-methyltransferase activity database_cross_reference "Reactome:R-HSA-2162186"
  • label "COQ3 methylates DeMQ10H2"

3-hydroxyisobutyryl-CoA hydrolase activity http://purl.obolibrary.org/obo/GO_0003860

Added

• 3-hydroxyisobutyryl-CoA hydrolase activity database_cross_reference "Reactome:R-HSA-9916727"
  • label "HIBCH mutants don't synthesize beta-hydroxyisobutyrate"

3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0036169

Removed

• 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity database_cross_reference "Reactome:R-HSA-2162195"
  • label "MHDB is decarboxylated to DMPhOH by MHDB decarboxylase"

Added

• 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity database_cross_reference "Reactome:R-HSA-2162195"
  • label "COQ4 decarboxylates MHDB"

3-methylbutanoyl-CoA dehydrogenase activity http://purl.obolibrary.org/obo/GO_0008470

Added

• 3-methylbutanoyl-CoA dehydrogenase activity database_cross_reference "Reactome:R-HSA-9914837"
  • label "IVD mutants don't synthesize beta-methylcrotonyl-CoA"

4-hydroxybenzaldehyde dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0018484

Added

• 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-9856794"
  • label "Unknown dehydrogenase oxidizes 4-HBz"

4-hydroxymandelate synthase activity http://purl.obolibrary.org/obo/GO_0050585

Added

• 4-hydroxymandelate synthase activity database_cross_reference "Reactome:R-HSA-9856718"
  • label "HPDL dioxygenates HPPA"

4-hydroxyphenylpyruvate dioxygenase activity http://purl.obolibrary.org/obo/GO_0003868

Removed

• 4-hydroxyphenylpyruvate dioxygenase activity database_cross_reference "Reactome:R-HSA-71163"
  • label "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2"

Added

• 4-hydroxyphenylpyruvate dioxygenase activity database_cross_reference "Reactome:R-HSA-71163"
  • label "HPD dioxygenates HPP"

ABC-type sterol transporter activity http://purl.obolibrary.org/obo/GO_0034041

Added

• ABC-type sterol transporter activity database_cross_reference "Reactome:R-HSA-265783"

  • label "ABCG5:ABCG8 transports sterols from cytosol to extracellular region"

• ABC-type sterol transporter activity database_cross_reference "Reactome:R-HSA-5679101"

  • label "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region"

• ABC-type sterol transporter activity database_cross_reference "Reactome:R-HSA-5679145"

  • label "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region"

AMP binding http://purl.obolibrary.org/obo/GO_0016208

Added

• AMP binding database_cross_reference "Reactome:R-HSA-380930"
  • label "Phosphorylated AMPK binds AMP"

ATP-activated inward rectifier potassium channel activity http://purl.obolibrary.org/obo/GO_0015272

Removed

• ATP-activated inward rectifier potassium channel activity database_cross_reference "Reactome:R-HSA-5683209"
  • label "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)."

Added

• ATP-activated inward rectifier potassium channel activity database_cross_reference "Reactome:R-HSA-5683209"
  • label "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)"

ATP:ATP adenylyltransferase activity http://purl.obolibrary.org/obo/GO_0141192

Added

• ATP:ATP adenylyltransferase activity database_cross_reference "Reactome:R-HSA-9825790"
  • label "p-S207 KARS1 dimer synthesizes A(5')p4(5')A"

ATPase-coupled transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0042626

Added

• ATPase-coupled transmembrane transporter activity database_cross_reference "Reactome:R-HSA-390393"
  • label "Peroxisomal uptake of very long-chain fatty acyl CoA"

CoA-transferase activity http://purl.obolibrary.org/obo/GO_0008410

Removed

• CoA-transferase activity database_cross_reference "Reactome:R-HSA-70713"
  • label "BCKDH transfers CoA group from CoA-SH to BCAAs"

DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates http://purl.obolibrary.org/obo/GO_0051719

Added

• DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates database_cross_reference "Reactome:R-HSA-9845308"
  • label "DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA"

DNA-binding transcription activator activity, RNA polymerase II-specific http://purl.obolibrary.org/obo/GO_0001228

Added

• DNA-binding transcription activator activity, RNA polymerase II-specific database_cross_reference "Reactome:R-HSA-9856548"

  • label "MLXIPL:MLX binds ACACB gene promoter"

• DNA-binding transcription activator activity, RNA polymerase II-specific database_cross_reference "Reactome:R-HSA-9856546"

  • label "MLXIPL:MLX binds FASN gene promoter"

• DNA-binding transcription activator activity, RNA polymerase II-specific database_cross_reference "Reactome:R-HSA-9856550"

  • label "MLXIPL:MLX binds ACACA gene promoter"

• DNA-binding transcription activator activity, RNA polymerase II-specific database_cross_reference "Reactome:R-HSA-9856549"

  • label "MLXIPL:MLX binds ACLY gene promoter"

• DNA-binding transcription activator activity, RNA polymerase II-specific database_cross_reference "Reactome:R-HSA-9856539"

  • label "MLXIPL:MLX binds PKLR gene promoter"

• DNA-binding transcription activator activity, RNA polymerase II-specific database_cross_reference "Reactome:R-HSA-9856604"

  • label "MLXIPL:MLX binds AGPAT1 gene promoter"

DNA-binding transcription factor activity http://purl.obolibrary.org/obo/GO_0003700

Added

• DNA-binding transcription factor activity database_cross_reference "Reactome:R-HSA-163666"
  • label "Formation of ChREBP:MLX heterodimer"

DNA-directed 5'-3' RNA polymerase activity http://purl.obolibrary.org/obo/GO_0003899

Removed

• DNA-directed 5'-3' RNA polymerase activity database_cross_reference "Reactome:R-HSA-9697084"
  • label "Defective rpoB in Mtb RNAP transcribes RNA polyanion"

Added

• DNA-directed 5'-3' RNA polymerase activity database_cross_reference "Reactome:R-HSA-9697084"
  • label "Defective RpoB in Mtb RNAP transcribes RNA polyanion"

G protein activity http://purl.obolibrary.org/obo/GO_0003925

Added

• G protein activity database_cross_reference "Reactome:R-HSA-422320"

  • label "Heterotrimeric G(s) complex dissociates"

• G protein activity database_cross_reference "Reactome:R-HSA-400037"

  • label "Gi,Go Heterotrimeric G-protein complex dissociates"

• G protein activity database_cross_reference "Reactome:R-HSA-400027"

  • label "Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma"

G protein-coupled acetylcholine receptor activity http://purl.obolibrary.org/obo/GO_0016907

Added

• G protein-coupled acetylcholine receptor activity database_cross_reference "Reactome:R-HSA-400012"
  • label "Acetylcholine binds Muscarinic Acetylcholine Receptor M3"

G protein-coupled receptor activity http://purl.obolibrary.org/obo/GO_0004930

Added

• G protein-coupled receptor activity database_cross_reference "Reactome:R-HSA-381706"
  • label "GLP1R:GLP1 activates G(s)"

GO_0004367 http://purl.obolibrary.org/obo/GO_0004367

Removed

• GO_0004367 database_cross_reference "Reactome:R-HSA-75889"
  • label "DHAP is converted to G3P by GPD1/GPD1L"

L-aspartate:2-oxoglutarate aminotransferase activity http://purl.obolibrary.org/obo/GO_0004069

Removed

• L-aspartate:2-oxoglutarate aminotransferase activity database_cross_reference "Reactome:R-HSA-70592"

  • label "PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate"

• L-aspartate:2-oxoglutarate aminotransferase activity database_cross_reference "Reactome:R-HSA-70613"

  • label "GOT2 transaminates oxaloacetate and glutamate"

Added

• L-aspartate:2-oxoglutarate aminotransferase activity database_cross_reference "Reactome:R-HSA-70613"

  • label "GOT2 transaminates OA and L-Glu"

• L-aspartate:2-oxoglutarate aminotransferase activity database_cross_reference "Reactome:R-HSA-70592"

  • label "PXLP-K259-GOT1 transaminates 2-OG and L-Asp"

L-malate dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0030060

Removed

• L-malate dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-71783"

  • label "MDH2 reduces OA to MAL"

• L-malate dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-70979"

  • label "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+"

• L-malate dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-198508"

  • label "MDH1 oxidizes MAL to OA"

Added

• L-malate dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-9856871"

  • label "MDH1 reduces OA"

• L-malate dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-70979"

  • label "MDH2 dimer dehydrogenates MAL"

L-tyrosine-2-oxoglutarate transaminase activity http://purl.obolibrary.org/obo/GO_0004838

Removed

• L-tyrosine-2-oxoglutarate transaminase activity database_cross_reference "Reactome:R-HSA-517444"

  • label "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate"

• L-tyrosine-2-oxoglutarate transaminase activity database_cross_reference "Reactome:R-HSA-71155"

  • label "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate"

Added

• L-tyrosine-2-oxoglutarate transaminase activity database_cross_reference "Reactome:R-HSA-517444"

  • label "TAT aminates HPP"

• L-tyrosine-2-oxoglutarate transaminase activity database_cross_reference "Reactome:R-HSA-71155"

  • label "TAT deaminates tyrosine"

MAP kinase activity http://purl.obolibrary.org/obo/GO_0004707

Removed

• MAP kinase activity database_cross_reference "Reactome:R-HSA-451366"

  • label "Activation of p38MAPK by DSCAM"

• MAP kinase activity database_cross_reference "Reactome:R-HSA-5654560"

  • label "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2."

• MAP kinase activity database_cross_reference "Reactome:R-HSA-5654566"

  • label "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2."

• MAP kinase activity database_cross_reference "Reactome:R-HSA-5654565"

  • label "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2."

Added

• MAP kinase activity database_cross_reference "Reactome:R-HSA-5654565"

  • label "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2"

• MAP kinase activity database_cross_reference "Reactome:R-HSA-9825759"

  • label "MAPK-dependent phosphorylation of KARS"

• MAP kinase activity database_cross_reference "Reactome:R-HSA-5654566"

  • label "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2"

• MAP kinase activity database_cross_reference "Reactome:R-HSA-5654560"

  • label "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2"

N-acylsphingosine galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0003851

Added

• N-acylsphingosine galactosyltransferase activity database_cross_reference "Reactome:R-HSA-6785933"
  • label "UGT8 transfers Gal from UDP-Gal to CERA"

N-acyltransferase activity http://purl.obolibrary.org/obo/GO_0016410

Added

• N-acyltransferase activity database_cross_reference "Reactome:R-HSA-9858752"

  • label "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT"

• N-acyltransferase activity database_cross_reference "Reactome:R-HSA-6792572"

  • label "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST"

NAD(P)+ transhydrogenase (Si-specific) activity http://purl.obolibrary.org/obo/GO_0003957

Added

• NAD(P)+ transhydrogenase (Si-specific) activity database_cross_reference "Reactome:R-HSA-450971"
  • label "NNT dimer transfers proton from NADPH to NAD+"

NAD+ nucleosidase activity http://purl.obolibrary.org/obo/GO_0003953

Removed

• NAD+ nucleosidase activity database_cross_reference "Reactome:R-HSA-8870346"

  • label "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose"

• NAD+ nucleosidase activity database_cross_reference "Reactome:R-HSA-8938076"

  • label "CD38 hydrolyses NAD+ to NAM and ADP-ribose"

NAD+ nucleotidase, cyclic ADP-ribose generating http://purl.obolibrary.org/obo/GO_0061809

Added

• NAD+ nucleotidase, cyclic ADP-ribose generating database_cross_reference "Reactome:R-HSA-8938076"

  • label "CD38 hydrolyses NAD+ to NAM and ADP-ribose"

• NAD+ nucleotidase, cyclic ADP-ribose generating database_cross_reference "Reactome:R-HSA-8870346"

  • label "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose"

• NAD+ nucleotidase, cyclic ADP-ribose generating database_cross_reference "Reactome:R-HSA-9637699"

  • label "CpnT hydrolyses NAD+"

NAD-dependent protein lysine deacetylase activity http://purl.obolibrary.org/obo/GO_0034979

Added

• NAD-dependent protein lysine deacetylase activity database_cross_reference "Reactome:R-HSA-9854463"
  • label "SIRT3 deacetylates AcK-IDH2 dimer"

NADH dehydrogenase (ubiquinone) activity http://purl.obolibrary.org/obo/GO_0008137

Removed

• NADH dehydrogenase (ubiquinone) activity database_cross_reference "Reactome:R-HSA-163217"
  • label "Complex I oxidises NADH to NAD+, reduces CoQ to QH2"

Added

• NADH dehydrogenase (ubiquinone) activity database_cross_reference "Reactome:R-HSA-163217"
  • label "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2"

NADH-dependent peroxiredoxin activity http://purl.obolibrary.org/obo/GO_0102039

Added

• NADH-dependent peroxiredoxin activity database_cross_reference "Reactome:R-HSA-1222526"
  • label "AhpC reduces peroxidated lipids"

NADPH dehydrogenase activity http://purl.obolibrary.org/obo/GO_0003959

Removed

• NADPH dehydrogenase activity database_cross_reference "Reactome:R-HSA-9018901"

  • label "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2"

• NADPH dehydrogenase activity database_cross_reference "Reactome:R-HSA-9027625"

  • label "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3"

• NADPH dehydrogenase activity database_cross_reference "Reactome:R-HSA-9027631"

  • label "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA"

• NADPH dehydrogenase activity database_cross_reference "Reactome:R-HSA-9027632"

  • label "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA"

Added

• NADPH dehydrogenase activity database_cross_reference "Reactome:R-HSA-9018901"
  • label "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HEPE to 18(R)-RvE2"

SUMO ligase activity http://purl.obolibrary.org/obo/GO_0061665

Added

• SUMO ligase activity database_cross_reference "Reactome:R-HSA-9842868"
  • label "TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2"

SUMO transferase activity http://purl.obolibrary.org/obo/GO_0019789

Removed

• SUMO transferase activity database_cross_reference "Reactome:R-HSA-4719424"
  • label "PIAS1 SUMOylates THRB with SUMO1."

Added

• SUMO transferase activity database_cross_reference "Reactome:R-HSA-4719424"
  • label "PIAS1 SUMOylates THRB with SUMO1"

UDP-glucuronate decarboxylase activity http://purl.obolibrary.org/obo/GO_0048040

Added

• UDP-glucuronate decarboxylase activity database_cross_reference "Reactome:R-HSA-8863761"
  • label "UXS1 tetramer decarboxylates UDP-glucuronate to UDP-xylose"

UDP-glucuronic acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005461

Added

• UDP-glucuronic acid transmembrane transporter activity database_cross_reference "Reactome:R-HSA-9912889"
  • label "SLC35D2 exchanges UDP-GlcA for UMP"

[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity http://purl.obolibrary.org/obo/GO_0047323

Added

• [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity database_cross_reference "Reactome:R-HSA-9912480"
  • label "BCKDK loss-of-function mutations do not phosphorylate BCKDH"

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity http://purl.obolibrary.org/obo/GO_0004741

Removed

• [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity database_cross_reference "Reactome:R-HSA-204169"
  • label "PDP dephosphorylates p-lipo-PDH"

Added

• [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity database_cross_reference "Reactome:R-HSA-204169"
  • label "PDP1,2 dephosphorylate p-lipo-PDH"

acetyl-CoA C-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0003985

Added

• acetyl-CoA C-acetyltransferase activity database_cross_reference "Reactome:R-HSA-9915356"
  • label "ACAT1 mutants don't synthesize propionyl-CoA or acetyl-CoA"

acetyl-CoA carboxylase activity http://purl.obolibrary.org/obo/GO_0003989

Removed

• acetyl-CoA carboxylase activity database_cross_reference "Reactome:R-HSA-200555"
  • label "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate"

Added

• acetyl-CoA carboxylase activity database_cross_reference "Reactome:R-HSA-200555"
  • label "Formation of Malonyl-CoA from Acetyl-CoA (liver)"

acetyl-CoA hydrolase activity http://purl.obolibrary.org/obo/GO_0003986

Removed

• acetyl-CoA hydrolase activity database_cross_reference "Reactome:R-HSA-390304"
  • label "acetyl-CoA + H2O => acetate + CoASH"

Added

• acetyl-CoA hydrolase activity database_cross_reference "Reactome:R-HSA-390304"
  • label "acetyl-CoA + H2O => acetate + CoASH + H+"

acetyltransferase activity http://purl.obolibrary.org/obo/GO_0016407

Added

• acetyltransferase activity database_cross_reference "Reactome:R-HSA-9854415"
  • label "ACAT1 tetramer acetylates IDH2 dimer"

acidic amino acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015172

Removed

• acidic amino acid transmembrane transporter activity database_cross_reference "Reactome:R-HSA-372448"
  • label "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp"

Added

• acidic amino acid transmembrane transporter activity database_cross_reference "Reactome:R-HSA-372448"
  • label "SLC25A12,13 exchange L-Glu and L-Asp"

aconitate hydratase activity http://purl.obolibrary.org/obo/GO_0003994

Removed

• aconitate hydratase activity database_cross_reference "Reactome:R-HSA-70971"

  • label "citrate <=> isocitrate"

• aconitate hydratase activity database_cross_reference "Reactome:R-HSA-450975"

  • label "isocitrate <=> citrate"

Added

• aconitate hydratase activity database_cross_reference "Reactome:R-HSA-70971"
  • label "ACO2 isomerizes citrate"

acyl carnitine transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015227

Removed

• acyl carnitine transmembrane transporter activity database_cross_reference "Reactome:R-HSA-200424"
  • label "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane"

acyl-CoA oxidase activity http://purl.obolibrary.org/obo/GO_0003997

Removed

• acyl-CoA oxidase activity database_cross_reference "Reactome:R-HSA-390256"
  • label "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2"

Added

• acyl-CoA oxidase activity database_cross_reference "Reactome:R-HSA-390256"
  • label "ACOX1 oxidizes C26:0 CoA"

acyltransferase activity http://purl.obolibrary.org/obo/GO_0016746

Removed

• acyltransferase activity database_cross_reference "Reactome:R-HSA-6792572"
  • label "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs"

acyltransferase activity, transferring groups other than amino-acyl groups http://purl.obolibrary.org/obo/GO_0016747

Added

• acyltransferase activity, transferring groups other than amino-acyl groups database_cross_reference "Reactome:R-HSA-9865115"

  • label "DBT loss-of-function mutants don't synthesize BCAA-CoA"

• acyltransferase activity, transferring groups other than amino-acyl groups database_cross_reference "Reactome:R-HSA-9859163"

  • label "DBT transfers BCAA to CoA"

adenylate cyclase activator activity http://purl.obolibrary.org/obo/GO_0010856

Added

• adenylate cyclase activator activity database_cross_reference "Reactome:R-HSA-381704"

  • label "G(s):GTP activates Adenylyl cyclase"

• adenylate cyclase activator activity database_cross_reference "Reactome:R-HSA-163617"

  • label "G alpha (s) activates adenylate cyclase"

adenylate cyclase inhibitor activity http://purl.obolibrary.org/obo/GO_0010855

Added

• adenylate cyclase inhibitor activity database_cross_reference "Reactome:R-HSA-400097"
  • label "G-beta:G-gamma inhibits Adenylate cyclase"

alcohol dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0004022

Added

• alcohol dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-71707"
  • label "ethanol + NAD+ => acetaldehyde + NADH + H+"

alkyl hydroperoxide reductase activity http://purl.obolibrary.org/obo/GO_0008785

Removed

• alkyl hydroperoxide reductase activity database_cross_reference "Reactome:R-HSA-1222526"
  • label "AhpC reduces peroxidated lipids"

all-trans-decaprenyl-diphosphate synthase activity http://purl.obolibrary.org/obo/GO_0097269

Removed

• all-trans-decaprenyl-diphosphate synthase activity database_cross_reference "Reactome:R-HSA-2162253"
  • label "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer"

Added

• all-trans-decaprenyl-diphosphate synthase activity database_cross_reference "Reactome:R-HSA-2162253"
  • label "PDSS1,2 ligates FPP to IPPP"

all-trans-retinol dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0052650

Removed

• all-trans-retinol dehydrogenase (NADP+) activity database_cross_reference "Reactome:R-HSA-2466861"

  • label "Defective RDH12 does not reduce atRAL to atROL and causes LCA13"

• all-trans-retinol dehydrogenase (NADP+) activity database_cross_reference "Reactome:R-HSA-2471670"

  • label "Defective RDH12 does not reduce atRAL to atROL"

Added

• all-trans-retinol dehydrogenase (NADP+) activity database_cross_reference "Reactome:R-HSA-2466861"
  • label "Defective RDH12 does not reduce atRAL to atROL"

alpha2-adrenergic receptor activity http://purl.obolibrary.org/obo/GO_0004938

Added

• alpha2-adrenergic receptor activity database_cross_reference "Reactome:R-HSA-400071"
  • label "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline"

amino acid:proton symporter activity http://purl.obolibrary.org/obo/GO_0005280

Removed

• amino acid:proton symporter activity database_cross_reference "Reactome:R-HSA-8875623"
  • label "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix"

Added

• amino acid:proton symporter activity database_cross_reference "Reactome:R-HSA-8875623"
  • label "SLC25A18,22 import L-Glu, H+"

aminopeptidase activity http://purl.obolibrary.org/obo/GO_0004177

Removed

• aminopeptidase activity database_cross_reference "Reactome:R-HSA-8851929"
  • label "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41)"

arachidonate 12(S)-lipoxygenase activity http://purl.obolibrary.org/obo/GO_0004052

Removed

• arachidonate 12(S)-lipoxygenase activity database_cross_reference "Reactome:R-HSA-2161964"

  • label "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15"

• arachidonate 12(S)-lipoxygenase activity database_cross_reference "Reactome:R-HSA-2161950"

  • label "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B"

• arachidonate 12(S)-lipoxygenase activity database_cross_reference "Reactome:R-HSA-2161948"

  • label "Arachidonic acid is converted to 12-oxoETE by ALOX12"

Added

• arachidonate 12(S)-lipoxygenase activity database_cross_reference "Reactome:R-HSA-2161964"

  • label "Arachidonate is oxidised to 12S-HpETE by ALOX12/15"

• arachidonate 12(S)-lipoxygenase activity database_cross_reference "Reactome:R-HSA-2161948"

  • label "Arachidonate is converted to 12-oxoETE by ALOX12"

• arachidonate 12(S)-lipoxygenase activity database_cross_reference "Reactome:R-HSA-2161950"

  • label "Arachidonate is oxidised to 12R-HpETE by ALOX12B"

arachidonate 15-lipoxygenase activity http://purl.obolibrary.org/obo/GO_0050473

Removed

• arachidonate 15-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9027627"

  • label "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)"

• arachidonate 15-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9020261"

  • label "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA"

• arachidonate 15-lipoxygenase activity database_cross_reference "Reactome:R-HSA-2161951"

  • label "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2"

• arachidonate 15-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9027607"

  • label "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3"

• arachidonate 15-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9027532"

  • label "PTGS2 dimer oxidises DHA to 13-HDHA"

• arachidonate 15-lipoxygenase activity database_cross_reference "Reactome:R-HSA-2162002"

  • label "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B"

• arachidonate 15-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9028255"

  • label "PTGS2 dimer oxidises EPA to PGH3"

Added

• arachidonate 15-lipoxygenase activity database_cross_reference "Reactome:R-HSA-2162002"
  • label "Arachidonate is oxidised to 15S-HpETE by ALOX15/15B"

arachidonate 5-lipoxygenase activity http://purl.obolibrary.org/obo/GO_0004051

Removed

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-265296"

  • label "Arachidonic acid is oxidised to 5S-HpETE by ALOX5"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9020255"

  • label "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9020264"

  • label "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9020256"

  • label "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9018894"

  • label "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9025999"

  • label "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9026405"

  • label "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9027624"

  • label "ALOX5 oxidises DHA to 7-HDHA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9020278"

  • label "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-266051"

  • label "5S-HpETE is dehydrated to LTA4 by ALOX5"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9020251"

  • label "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9026005"

  • label "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9027628"

  • label "ALOX5 oxidises EPA to 5-HEPE"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9025996"

  • label "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9020282"

  • label "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9018863"

  • label "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9018858"

  • label "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9018859"

  • label "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9025995"

  • label "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9020259"

  • label "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9020277"

  • label "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9027633"

  • label "ALOX5 oxidises DPAn-3 to 7-HDPAn-3"

• arachidonate 5-lipoxygenase activity database_cross_reference "Reactome:R-HSA-9024997"

  • label "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA"

bile acid nuclear receptor activity http://purl.obolibrary.org/obo/GO_0038186

Added

• bile acid nuclear receptor activity database_cross_reference "Reactome:R-HSA-5340195"
  • label "NR1H4 binds DCA, CDCA, LCHA"

broad specificity oxidative DNA demethylase activity http://purl.obolibrary.org/obo/GO_0035516

Added

• broad specificity oxidative DNA demethylase activity database_cross_reference "Reactome:R-HSA-112123"

  • label "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"

• broad specificity oxidative DNA demethylase activity database_cross_reference "Reactome:R-HSA-112118"

  • label "Oxidative demethylation of 1-meA damaged DNA by ALKBH2"

cAMP binding http://purl.obolibrary.org/obo/GO_0030552

Added

• cAMP binding database_cross_reference "Reactome:R-HSA-111925"

  • label "cAMP induces dissociation of inactive PKA tetramers"

• cAMP binding database_cross_reference "Reactome:R-HSA-381668"

  • label "cAMP activates EPAC1"

• cAMP binding database_cross_reference "Reactome:R-HSA-381608"

  • label "cAMP activates EPAC2"

• cAMP binding database_cross_reference "Reactome:R-HSA-381707"

  • label "PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP"

cAMP-dependent protein kinase activity http://purl.obolibrary.org/obo/GO_0004691

Added

• cAMP-dependent protein kinase activity database_cross_reference "Reactome:R-HSA-9861318"
  • label "PKA phosphorylates NOS3 (eNOS) on serine-633"

calcium channel activity http://purl.obolibrary.org/obo/GO_0005262

Added

• calcium channel activity database_cross_reference "Reactome:R-HSA-9858800"
  • label "TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol"

calcium-dependent cysteine-type endopeptidase activity http://purl.obolibrary.org/obo/GO_0004198

Added

• calcium-dependent cysteine-type endopeptidase activity database_cross_reference "Reactome:R-HSA-9861485"

  • label "Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)"

• calcium-dependent cysteine-type endopeptidase activity database_cross_reference "Reactome:R-HSA-9855106"

  • label "Calpain2 (m-Calpain) cleaves TLN1 (Talin-1)"

calcium-dependent phospholipase A2 activity http://purl.obolibrary.org/obo/GO_0047498

Removed

• calcium-dependent phospholipase A2 activity database_cross_reference "Reactome:R-HSA-111883"
  • label "Hydrolysis of phosphatidylcholine"

Added

• calcium-dependent phospholipase A2 activity database_cross_reference "Reactome:R-HSA-111883"

  • label "PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine"

• calcium-dependent phospholipase A2 activity database_cross_reference "Reactome:R-HSA-111881"

  • label "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase"

calcium-induced calcium release activity http://purl.obolibrary.org/obo/GO_0048763

Added

• calcium-induced calcium release activity database_cross_reference "Reactome:R-HSA-2855020"
  • label "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol"

calmodulin binding http://purl.obolibrary.org/obo/GO_0005516

Added

• calmodulin binding database_cross_reference "Reactome:R-HSA-202110"
  • label "eNOS:Caveolin-1 complex binds to CaM"

carbon-carbon lyase activity http://purl.obolibrary.org/obo/GO_0016830

Added

• carbon-carbon lyase activity database_cross_reference "Reactome:R-HSA-189425"

  • label "UROD decarboxylates URO3 to COPRO3"

• carbon-carbon lyase activity database_cross_reference "Reactome:R-HSA-190182"

  • label "UROD decarboxylates URO1 to COPRO1"

carboxylesterase activity http://purl.obolibrary.org/obo/GO_0106435

Removed

• carboxylesterase activity database_cross_reference "Reactome:R-HSA-9619024"
  • label "CES1trimer hydrolyses ACEI pro-drugs to ACEIs"

Added

• carboxylesterase activity database_cross_reference "Reactome:R-HSA-9619024"
  • label "CES1 trimer hydrolyses ACEI pro-drugs to ACEIs"

cargo adaptor activity http://purl.obolibrary.org/obo/GO_0140312

Added

• cargo adaptor activity database_cross_reference "Reactome:R-HSA-203565"

  • label "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP"

• cargo adaptor activity database_cross_reference "Reactome:R-HSA-203662"

  • label "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2"

cargo receptor activity http://purl.obolibrary.org/obo/GO_0038024

Added

• cargo receptor activity database_cross_reference "Reactome:R-HSA-203716"
  • label "eNOS:Caveolin-1 complex binds to Nostrin"

carnitine O-palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0004095

Removed

• carnitine O-palmitoyltransferase activity database_cross_reference "Reactome:R-HSA-200406"

  • label "CPT1A,B transfers PALM to CAR"

• carnitine O-palmitoyltransferase activity database_cross_reference "Reactome:R-HSA-200410"

  • label "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine"

Added

• carnitine O-palmitoyltransferase activity database_cross_reference "Reactome:R-HSA-200406"

  • label "CPT1A transfers PALM to CAR"

• carnitine O-palmitoyltransferase activity database_cross_reference "Reactome:R-HSA-9911362"

  • label "CPT1B transfers PALM to CAR"

• carnitine O-palmitoyltransferase activity database_cross_reference "Reactome:R-HSA-200410"

  • label "CPT2 converts palmitoyl carnitine to palmitoyl-CoA"

carnitine:acyl carnitine antiporter activity http://purl.obolibrary.org/obo/GO_0005476

Added

• carnitine:acyl carnitine antiporter activity database_cross_reference "Reactome:R-HSA-200424"
  • label "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane"

chloride channel activity http://purl.obolibrary.org/obo/GO_0005254

Added

• chloride channel activity database_cross_reference "Reactome:R-HSA-2744242"

  • label "TTYH2/3 transport cytosolic Cl- to extracellular region"

• chloride channel activity database_cross_reference "Reactome:R-HSA-2684901"

  • label "ANOs transport cytosolic Cl- to extracellular region"

• chloride channel activity database_cross_reference "Reactome:R-HSA-2744361"

  • label "BESTs transport cytosolic Cl- to extracellular region"

• chloride channel activity database_cross_reference "Reactome:R-HSA-9659568"

  • label "ANO1 transports cytosolic Cl- to extracellular region"

citrate (Si)-synthase activity http://purl.obolibrary.org/obo/GO_0004108

Removed

• citrate (Si)-synthase activity database_cross_reference "Reactome:R-HSA-70975"
  • label "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA"

Added

• citrate (Si)-synthase activity database_cross_reference "Reactome:R-HSA-70975"
  • label "CS acetylates OA to citrate"

copper chaperone activity http://purl.obolibrary.org/obo/GO_0016531

Added

• copper chaperone activity database_cross_reference "Reactome:R-HSA-9865449"

  • label "Metallochaperone inserts Cu2+ into MT-CO1"

• copper chaperone activity database_cross_reference "Reactome:R-HSA-9865579"

  • label "MT-CO1 and MT-CO2 complexes associate, installing heme moieties"

• copper chaperone activity database_cross_reference "Reactome:R-HSA-9865630"

  • label "Metallochaperone inserts 2Cu2+ into MT-CO2"

corrinoid adenosyltransferase activity http://purl.obolibrary.org/obo/GO_0008817

Added

• corrinoid adenosyltransferase activity database_cross_reference "Reactome:R-HSA-3159253"
  • label "MMAB adenosylates cob(I)alamin"

diacylglycerol binding http://purl.obolibrary.org/obo/GO_0019992

Added

• diacylglycerol binding database_cross_reference "Reactome:R-HSA-400015"
  • label "Diacylgycerol activates Protein kinase C, alpha type"

dihydrolipoyl dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004148

Removed

• dihydrolipoyl dehydrogenase activity database_cross_reference "Reactome:R-HSA-1222412"
  • label "lpdC dimer reactivates dlaT"

Added

• dihydrolipoyl dehydrogenase activity database_cross_reference "Reactome:R-HSA-9907572"

  • label "Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT"

• dihydrolipoyl dehydrogenase activity database_cross_reference "Reactome:R-HSA-1222412"

  • label "LpdC dimer reactivates DlaT"

• dihydrolipoyl dehydrogenase activity database_cross_reference "Reactome:R-HSA-9858589"

  • label "DLD dimer dehydrogenates dihydrolipoyl"

• dihydrolipoyl dehydrogenase activity database_cross_reference "Reactome:R-HSA-9859172"

  • label "DLD dimer dehydrogenates dihydrolipoyl"

• dihydrolipoyl dehydrogenase activity database_cross_reference "Reactome:R-HSA-9861616"

  • label "DLD dimer dehydrogenates dihydrolipoyl"

• dihydrolipoyl dehydrogenase activity database_cross_reference "Reactome:R-HSA-9853499"

  • label "DLD dimer dehydrogenates dihydrolipoyl"

dihydrolipoyllysine-residue acetyltransferase activity http://purl.obolibrary.org/obo/GO_0004742

Added

• dihydrolipoyllysine-residue acetyltransferase activity database_cross_reference "Reactome:R-HSA-9861667"
  • label "DLAT trimer transfers acetyl to CoA"

dihydrolipoyllysine-residue succinyltransferase activity http://purl.obolibrary.org/obo/GO_0004149

Added

• dihydrolipoyllysine-residue succinyltransferase activity database_cross_reference "Reactome:R-HSA-9853512"

  • label "DLST transfers succinyl to CoA"

• dihydrolipoyllysine-residue succinyltransferase activity database_cross_reference "Reactome:R-HSA-9858590"

  • label "DLST transfers glutaryl to CoA"

dihydrosphingosine-1-phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0070780

Removed

• dihydrosphingosine-1-phosphate phosphatase activity database_cross_reference "Reactome:R-HSA-428664"
  • label "SGPP1,2 dephosphorylate sphingoid-1-phosphates"

dimethylargininase activity http://purl.obolibrary.org/obo/GO_0016403

Removed

• dimethylargininase activity database_cross_reference "Reactome:R-HSA-5693373"
  • label "DDAH1,2 hydrolyses ADMA to DMA and L-Cit"

Added

• dimethylargininase activity database_cross_reference "Reactome:R-HSA-5693373"
  • label "DDAH1 hydrolyses ADMA to DMA and L-Cit"

diphthine methyl ester synthase activity http://purl.obolibrary.org/obo/GO_0141133

Added

• diphthine methyl ester synthase activity database_cross_reference "Reactome:R-HSA-5358484"
  • label "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2"

diphthine synthase activity http://purl.obolibrary.org/obo/GO_0004164

Removed

• diphthine synthase activity database_cross_reference "Reactome:R-HSA-5358484"
  • label "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2"

electron-transferring-flavoprotein dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004174

Removed

• electron-transferring-flavoprotein dehydrogenase activity database_cross_reference "Reactome:R-HSA-169270"
  • label "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2"

Added

• electron-transferring-flavoprotein dehydrogenase activity database_cross_reference "Reactome:R-HSA-169270"
  • label "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2"

endopeptidase activity http://purl.obolibrary.org/obo/GO_0004175

Removed

• endopeptidase activity database_cross_reference "Reactome:R-HSA-9008475"

  • label "Proteasome degrades polyubiquitinated RUNX2"

• endopeptidase activity database_cross_reference "Reactome:R-HSA-1236970"

  • label "Proteasomal clevage of exogenous antigen"

• endopeptidase activity database_cross_reference "Reactome:R-HSA-1236935"

  • label "Proteasomal cleavage of substrate"

Added

• endopeptidase activity database_cross_reference "Reactome:R-HSA-1236970"

  • label "Proteasomal clevage of exogenous antigen (26S proteasome catalyst)"

• endopeptidase activity database_cross_reference "Reactome:R-HSA-1236935"

  • label "Proteasomal cleavage of substrate (26S proteasome catalyst)"

• endopeptidase activity database_cross_reference "Reactome:R-HSA-9908101"

  • label "Maturation of the canonical 20S core particle"

• endopeptidase activity database_cross_reference "Reactome:R-HSA-9906017"

  • label "Unknown peptidase cleaves UQCRFS1 subunit"

• endopeptidase activity database_cross_reference "Reactome:R-HSA-9908108"

  • label "Maturation of the 20S thymoproteasome core particle"

• endopeptidase activity database_cross_reference "Reactome:R-HSA-9839376"

  • label "TGFBR3(784-851) degradation"

• endopeptidase activity database_cross_reference "Reactome:R-HSA-9908105"

  • label "Maturation of the 20S immunoproteasome core particle"

• endopeptidase activity database_cross_reference "Reactome:R-HSA-9908780"

  • label "Maturation of the preholospermatoproteasome"

enoyl-CoA hydratase activity http://purl.obolibrary.org/obo/GO_0004300

Added

• enoyl-CoA hydratase activity database_cross_reference "Reactome:R-HSA-9916717"
  • label "ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA"

enzyme-substrate adaptor activity http://purl.obolibrary.org/obo/GO_0140767

Added

• enzyme-substrate adaptor activity database_cross_reference "Reactome:R-HSA-202137"
  • label "AKT1 binds eNOS complex via HSP90"

epoxide hydrolase activity http://purl.obolibrary.org/obo/GO_0004301

Removed

• epoxide hydrolase activity database_cross_reference "Reactome:R-HSA-2161961"
  • label "EET(1) is hydrolysed to DHET(1) by EPHX2"

Added

• epoxide hydrolase activity database_cross_reference "Reactome:R-HSA-2161961"

  • label "5,6-EET is hydrolysed to 5,6-DHET by EPHX2"

• epoxide hydrolase activity database_cross_reference "Reactome:R-HSA-9915994"

  • label "14,15-EET is hydrolysed to 14,15-DHET by EPHX2"

• epoxide hydrolase activity database_cross_reference "Reactome:R-HSA-9915968"

  • label "8,9-EET is hydrolysed to 8.9-DHET by EPHX2"

• epoxide hydrolase activity database_cross_reference "Reactome:R-HSA-9915986"

  • label "11,12-EET is hydrolysed to 11,12-DHET by EPHX2"

fatty acid synthase activity http://purl.obolibrary.org/obo/GO_0004312

Removed

• fatty acid synthase activity database_cross_reference "Reactome:R-HSA-75872"
  • label "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O"

Added

• fatty acid synthase activity database_cross_reference "Reactome:R-HSA-163756"

  • label "Formation of fatty acid synthase (FAS) dimer"

• fatty acid synthase activity database_cross_reference "Reactome:R-HSA-75872"

  • label "Conversion of malonyl-CoA and acetyl-CoA to palmitate"

fatty acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015245

Added

• fatty acid transmembrane transporter activity database_cross_reference "Reactome:R-HSA-9032323"

  • label "oxo-DPAn-3s translocate from cytosol to extracellular region"

• fatty acid transmembrane transporter activity database_cross_reference "Reactome:R-HSA-9032315"

  • label "oxo-DHAs translocate from cytosol to extracellular region"

fatty-acyl-CoA binding http://purl.obolibrary.org/obo/GO_0000062

Added

• fatty-acyl-CoA binding database_cross_reference "Reactome:R-HSA-8848247"
  • label "ACBD4,5 bind MCFA-CoA and LCFA-CoA"

ferric-chelate reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0052851

Added

• ferric-chelate reductase (NADPH) activity database_cross_reference "Reactome:R-HSA-917811"
  • label "STEAP3,STEAP4 reduce Fe3+ to Fe2+"

fumarate hydratase activity http://purl.obolibrary.org/obo/GO_0004333

Removed

• fumarate hydratase activity database_cross_reference "Reactome:R-HSA-451033"

  • label "(S)-Malate <=> Fumarate + H2O"

• fumarate hydratase activity database_cross_reference "Reactome:R-HSA-70982"

  • label "Fumarate + H2O <=> (S)-Malate"

Added

• fumarate hydratase activity database_cross_reference "Reactome:R-HSA-70982"
  • label "FH tetramer hydrates fumarate to L-malate"

fumarylacetoacetase activity http://purl.obolibrary.org/obo/GO_0004334

Removed

• fumarylacetoacetase activity database_cross_reference "Reactome:R-HSA-71181"
  • label "fumarylacetoacetate => fumarate + acetoacetate"

Added

• fumarylacetoacetase activity database_cross_reference "Reactome:R-HSA-71181"
  • label "FAH cleaves 4FAA"

glutathione transferase activity http://purl.obolibrary.org/obo/GO_0004364

Added

• glutathione transferase activity database_cross_reference "Reactome:R-HSA-9011595"
  • label "GSTZ1 dimer dehalogenates DCA"

glycerol-3-phosphate dehydrogenase [NAD(P)+] activity http://purl.obolibrary.org/obo/GO_0047952

Added

• glycerol-3-phosphate dehydrogenase [NAD(P)+] activity database_cross_reference "Reactome:R-HSA-75889"
  • label "DHAP is converted to G3P by GPD1/GPD1L"

glycolipid transfer activity http://purl.obolibrary.org/obo/GO_0017089

Removed

• glycolipid transfer activity database_cross_reference "Reactome:R-HSA-9697077"
  • label "Rv1410c transports lprG:LM,LAM from cytosol to the cell wall"

Added

• glycolipid transfer activity database_cross_reference "Reactome:R-HSA-9697077"
  • label "Rv1410c transports LprG:LM,LAM from cytosol to the cell wall"

glycylpeptide N-tetradecanoyltransferase activity http://purl.obolibrary.org/obo/GO_0004379

Added

• glycylpeptide N-tetradecanoyltransferase activity database_cross_reference "Reactome:R-HSA-203611"
  • label "N-myristoylation of eNOS"

guanyl-nucleotide exchange factor activity http://purl.obolibrary.org/obo/GO_0005085

Removed

• guanyl-nucleotide exchange factor activity database_cross_reference "Reactome:R-HSA-1250498"

  • label "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers."

• guanyl-nucleotide exchange factor activity database_cross_reference "Reactome:R-HSA-416530"

  • label "FFAR1:FFAR1 ligands activates Gq"

Added

• guanyl-nucleotide exchange factor activity database_cross_reference "Reactome:R-HSA-1250498"

  • label "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers"

• guanyl-nucleotide exchange factor activity database_cross_reference "Reactome:R-HSA-400092"

  • label "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins"

• guanyl-nucleotide exchange factor activity database_cross_reference "Reactome:R-HSA-416530"

  • label "FFAR1:FFAR1 ligands activate Gq"

hepoxilin A3 synthase activity http://purl.obolibrary.org/obo/GO_0051120

Removed

• hepoxilin A3 synthase activity database_cross_reference "Reactome:R-HSA-2161794"
  • label "Arachidonic acid is converted to HXA3/B3 by ALOX12"

Added

• hepoxilin A3 synthase activity database_cross_reference "Reactome:R-HSA-2161794"
  • label "Arachidonate is converted to HXA3/B3 by ALOX12"

histone H3 methyltransferase activity http://purl.obolibrary.org/obo/GO_0140938

Added

• histone H3 methyltransferase activity database_cross_reference "Reactome:R-HSA-9844057"

  • label "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome"

• histone H3 methyltransferase activity database_cross_reference "Reactome:R-HSA-9844006"

  • label "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)"

• histone H3 methyltransferase activity database_cross_reference "Reactome:R-HSA-9842833"

  • label "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes"

histone H3K4 methyltransferase activity http://purl.obolibrary.org/obo/GO_0042800

Added

• histone H3K4 methyltransferase activity database_cross_reference "Reactome:R-HSA-9843121"
  • label "KMT2D,(KMT2C) complex monomethylates nucleosomes at PPARG:RXRA-bound enhancers"

histone H3K9 methyltransferase activity http://purl.obolibrary.org/obo/GO_0046974

Removed

• histone H3K9 methyltransferase activity database_cross_reference "Reactome:R-HSA-427336"
  • label "TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9."

Added

• histone H3K9 methyltransferase activity database_cross_reference "Reactome:R-HSA-427336"
  • label "TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9"

holocytochrome-c synthase activity http://purl.obolibrary.org/obo/GO_0004408

Added

• holocytochrome-c synthase activity database_cross_reference "Reactome:R-HSA-9866217"
  • label "HCCS inserts heme into cytochrome c"

homogentisate 1,2-dioxygenase activity http://purl.obolibrary.org/obo/GO_0004411

Removed

• homogentisate 1,2-dioxygenase activity database_cross_reference "Reactome:R-HSA-71164"
  • label "homogentisate + O2 => maleylacetoacetate"

Added

• homogentisate 1,2-dioxygenase activity database_cross_reference "Reactome:R-HSA-71164"
  • label "HGD dioxygenates homogentisate"

hydro-lyase activity http://purl.obolibrary.org/obo/GO_0016836

Added

• hydro-lyase activity database_cross_reference "Reactome:R-HSA-2161659"
  • label "PGE2 is dehydrated to PGA2"

hydrolase activity, acting on acid halide bonds, in C-halide compounds http://purl.obolibrary.org/obo/GO_0019120

Removed

• hydrolase activity, acting on acid halide bonds, in C-halide compounds database_cross_reference "Reactome:R-HSA-9011595"
  • label "GSTZ1 dimer dehalogenates DCA to glyoxylate"

icosanoid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0071714

Added

• icosanoid transmembrane transporter activity database_cross_reference "Reactome:R-HSA-428990"
  • label "SLC27A1 transports arachidonate across the ER membrane"

intracellularly calcium-gated chloride channel activity http://purl.obolibrary.org/obo/GO_0005229

Removed

• intracellularly calcium-gated chloride channel activity database_cross_reference "Reactome:R-HSA-9659568"

  • label "ANO1 transports cytosolic Cl- to extracellular region"

• intracellularly calcium-gated chloride channel activity database_cross_reference "Reactome:R-HSA-2744361"

  • label "BESTs transport cytosolic Cl- to extracellular region"

• intracellularly calcium-gated chloride channel activity database_cross_reference "Reactome:R-HSA-2744242"

  • label "TTYH2/3 transport cytosolic Cl- to extracellular region"

• intracellularly calcium-gated chloride channel activity database_cross_reference "Reactome:R-HSA-2684901"

  • label "ANOs transport cytosolic Cl- to extracellular region"

iodide channel activity http://purl.obolibrary.org/obo/GO_0160081

Added

• iodide channel activity database_cross_reference "Reactome:R-HSA-429767"
  • label "Passive I- efflux mediated by SLC5A8"

iron chaperone activity http://purl.obolibrary.org/obo/GO_0034986

Added

• iron chaperone activity database_cross_reference "Reactome:R-HSA-9854405"

  • label "Frataxin transfers Fe2+ to ACO2"

• iron chaperone activity database_cross_reference "Reactome:R-HSA-9854984"

  • label "Transfer of Fe-S clusters to SDHB"

• iron chaperone activity database_cross_reference "Reactome:R-HSA-9866272"

  • label "2Fe-2S is inserted in UQCRFS1"

iron-sulfur cluster binding http://purl.obolibrary.org/obo/GO_0051536

Added

• iron-sulfur cluster binding database_cross_reference "Reactome:R-HSA-5690873"
  • label "ACO1 binds 4Fe-4S"

isocitrate dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0004449

Removed

• isocitrate dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-70967"
  • label "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]"

Added

• isocitrate dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-70967"
  • label "IDH3 complex decarboxylates isocitrate"

isocitrate dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0004450

Removed

• isocitrate dehydrogenase (NADP+) activity database_cross_reference "Reactome:R-HSA-450984"
  • label "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]"

Added

• isocitrate dehydrogenase (NADP+) activity database_cross_reference "Reactome:R-HSA-450984"
  • label "IDH2 dimer decarboxylates isocitrate"

isomerase activity http://purl.obolibrary.org/obo/GO_0016853

Added

• isomerase activity database_cross_reference "Reactome:R-HSA-2161735"

  • label "PGC2 is isomerised to PGB2"

• isomerase activity database_cross_reference "Reactome:R-HSA-2161666"

  • label "PGA2 is isomerised to PGC2"

lipid transfer activity http://purl.obolibrary.org/obo/GO_0120013

Added

• lipid transfer activity database_cross_reference "Reactome:R-HSA-9856502"

  • label "mito-STARD7 transports Q10 to outer mitochondrial membrane"

• lipid transfer activity database_cross_reference "Reactome:R-HSA-9856510"

  • label "STARD7 transports Q10 to plasma membrane"

lipoamidase activity http://purl.obolibrary.org/obo/GO_0061690

Added

• lipoamidase activity database_cross_reference "Reactome:R-HSA-9861626"
  • label "SIRT4 cleaves lipoyl from DLAT"

lipoate synthase activity http://purl.obolibrary.org/obo/GO_0016992

Removed

• lipoate synthase activity database_cross_reference "Reactome:R-HSA-6793591"
  • label "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH"

Added

• lipoate synthase activity database_cross_reference "Reactome:R-HSA-6793591"
  • label "LIAS synthesizes lipoyl-GCSH"

long-chain fatty acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005324

Removed

• long-chain fatty acid transmembrane transporter activity database_cross_reference "Reactome:R-HSA-390393"
  • label "Peroxisomal uptake of very long-chain fatty acyl CoA"

mRNA regulatory element binding translation repressor activity http://purl.obolibrary.org/obo/GO_0000900

Added

• mRNA regulatory element binding translation repressor activity database_cross_reference "Reactome:R-HSA-5690886"
  • label "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs"

malate dehydrogenase (decarboxylating) (NAD+) activity http://purl.obolibrary.org/obo/GO_0004471

Removed

• malate dehydrogenase (decarboxylating) (NAD+) activity database_cross_reference "Reactome:R-HSA-9012268"
  • label "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR"

Added

• malate dehydrogenase (decarboxylating) (NAD+) activity database_cross_reference "Reactome:R-HSA-9012268"
  • label "ME2 tetramer decarboxylates MAL to PYR"

malate dehydrogenase (decarboxylating) (NADP+) activity http://purl.obolibrary.org/obo/GO_0004473

Removed

• malate dehydrogenase (decarboxylating) (NADP+) activity database_cross_reference "Reactome:R-HSA-9012036"

  • label "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR"

• malate dehydrogenase (decarboxylating) (NADP+) activity database_cross_reference "Reactome:R-HSA-9012349"

  • label "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR"

Added

• malate dehydrogenase (decarboxylating) (NADP+) activity database_cross_reference "Reactome:R-HSA-9012036"

  • label "ME1 tetramer decarboxylates MAL to PYR"

• malate dehydrogenase (decarboxylating) (NADP+) activity database_cross_reference "Reactome:R-HSA-9012349"

  • label "ME3 tetramer decarboxylates MAL to PYR"

maleylacetoacetate isomerase activity http://purl.obolibrary.org/obo/GO_0016034

Removed

• maleylacetoacetate isomerase activity database_cross_reference "Reactome:R-HSA-71173"
  • label "maleylacetoacetate => fumarylacetoacetate"

Added

• maleylacetoacetate isomerase activity database_cross_reference "Reactome:R-HSA-71173"
  • label "GSTZ1 isomerizes 4-MAA"

mannokinase activity http://purl.obolibrary.org/obo/GO_0019158

Added

• mannokinase activity database_cross_reference "Reactome:R-HSA-9909159"
  • label "HK1 phosphorylates Mannose to Man6P"

mannose-1-phosphate guanylyltransferase (GTP) activity http://purl.obolibrary.org/obo/GO_0004475

Removed

• mannose-1-phosphate guanylyltransferase (GTP) activity database_cross_reference "Reactome:R-HSA-446221"
  • label "Mannose-1-phosphate converted to GDP-Mannose"

Added

• mannose-1-phosphate guanylyltransferase (GTP) activity database_cross_reference "Reactome:R-HSA-446221"
  • label "GMPPB converts Mannose-1-phosphate to GDP-Mannose"

mechanosensitive monoatomic cation channel activity http://purl.obolibrary.org/obo/GO_0140135

Added

• mechanosensitive monoatomic cation channel activity database_cross_reference "Reactome:R-HSA-9855089"
  • label "PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients"

medium-chain fatty acid-CoA ligase activity http://purl.obolibrary.org/obo/GO_0031956

Added

• medium-chain fatty acid-CoA ligase activity database_cross_reference "Reactome:R-HSA-8875013"
  • label "ACSM3,ACSM6 ligate CoA to BUT"

membrane insertase activity http://purl.obolibrary.org/obo/GO_0032977

Added

• membrane insertase activity database_cross_reference "Reactome:R-HSA-9902096"

  • label "COX18 inserts nascent MT-CO2 in COX20:TMEM77"

• membrane insertase activity database_cross_reference "Reactome:R-HSA-9906955"

  • label "MT-ND4 is translated"

metallocarboxypeptidase activity http://purl.obolibrary.org/obo/GO_0004181

Removed

• metallocarboxypeptidase activity database_cross_reference "Reactome:R-HSA-2022378"

  • label "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)"

• metallocarboxypeptidase activity database_cross_reference "Reactome:R-HSA-2022379"

  • label "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)"

Added

• metallocarboxypeptidase activity database_cross_reference "Reactome:R-HSA-2022379"

  • label "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)"

• metallocarboxypeptidase activity database_cross_reference "Reactome:R-HSA-2022378"

  • label "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)"

metallodipeptidase activity http://purl.obolibrary.org/obo/GO_0070573

Removed

• metallodipeptidase activity database_cross_reference "Reactome:R-HSA-2022398"

  • label "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)"

• metallodipeptidase activity database_cross_reference "Reactome:R-HSA-2022405"

  • label "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"

• metallodipeptidase activity database_cross_reference "Reactome:R-HSA-2065355"

  • label "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"

Added

• metallodipeptidase activity database_cross_reference "Reactome:R-HSA-2022398"

  • label "ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)"

• metallodipeptidase activity database_cross_reference "Reactome:R-HSA-2065355"

  • label "Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"

• metallodipeptidase activity database_cross_reference "Reactome:R-HSA-2022405"

  • label "ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"

metalloendopeptidase activity http://purl.obolibrary.org/obo/GO_0004222

Removed

• metalloendopeptidase activity database_cross_reference "Reactome:R-HSA-2533950"
  • label "Fibronectin degradation by MMP14, TMPRSS6"

Added

• metalloendopeptidase activity database_cross_reference "Reactome:R-HSA-2533950"
  • label "Fibronectin degradation by MMP14"

metallopeptidase activity http://purl.obolibrary.org/obo/GO_0008237

Removed

• metallopeptidase activity database_cross_reference "Reactome:R-HSA-2022368"

  • label "MME:Zn2+ hydrolyses AGT(34-42)"

• metallopeptidase activity database_cross_reference "Reactome:R-HSA-2022393"

  • label "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)"

• metallopeptidase activity database_cross_reference "Reactome:R-HSA-2022396"

  • label "MME:Zn2+ hydrolyses AGT(34-43)"

• metallopeptidase activity database_cross_reference "Reactome:R-HSA-2022399"

  • label "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)"

Added

• metallopeptidase activity database_cross_reference "Reactome:R-HSA-2022399"

  • label "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)"

• metallopeptidase activity database_cross_reference "Reactome:R-HSA-2022393"

  • label "ANPEP:Zn2+ hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)"

• metallopeptidase activity database_cross_reference "Reactome:R-HSA-2022396"

  • label "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43)"

• metallopeptidase activity database_cross_reference "Reactome:R-HSA-2022368"

  • label "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42)"

methylcrotonoyl-CoA carboxylase activity http://purl.obolibrary.org/obo/GO_0004485

Removed

• methylcrotonoyl-CoA carboxylase activity database_cross_reference "Reactome:R-HSA-508308"
  • label "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]"

Added

• methylcrotonoyl-CoA carboxylase activity database_cross_reference "Reactome:R-HSA-9909466"

  • label "MCCC mutants don't synthesize beta-methylglutaconyl-CoA"

• methylcrotonoyl-CoA carboxylase activity database_cross_reference "Reactome:R-HSA-508308"

  • label "beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + CO2 (MCCA)"

methylglutaconyl-CoA hydratase activity http://purl.obolibrary.org/obo/GO_0004490

Added

• methylglutaconyl-CoA hydratase activity database_cross_reference "Reactome:R-HSA-9914271"
  • label "AUH mutants don't synthesize 3-hydroxy-methylglutaryl-CoA"

molecular carrier activity http://purl.obolibrary.org/obo/GO_0140104

Added

• molecular carrier activity database_cross_reference "Reactome:R-HSA-3149563"

  • label "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria"

• molecular carrier activity database_cross_reference "Reactome:R-HSA-3149494"

  • label "MMACHC:cob(II)alamin binds MMADHC"

• molecular carrier activity database_cross_reference "Reactome:R-HSA-1449687"

  • label "Corticosteroids bind to CBG in blood"

• molecular carrier activity database_cross_reference "Reactome:R-HSA-3159259"

  • label "MMAA:MUT binds AdoCbl"

• molecular carrier activity database_cross_reference "Reactome:R-HSA-3204318"

  • label "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR"

molecular sequestering activity http://purl.obolibrary.org/obo/GO_0140313

Added

• molecular sequestering activity database_cross_reference "Reactome:R-HSA-203553"

  • label "eNOS binds NOSIP"

• molecular sequestering activity database_cross_reference "Reactome:R-HSA-203680"

  • label "eNOS:NOSIP translocation from caveolae to intracellular compartments"

monoatomic anion channel activity http://purl.obolibrary.org/obo/GO_0005253

Added

• monoatomic anion channel activity database_cross_reference "Reactome:R-HSA-9855161"
  • label "Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region"

monooxygenase activity http://purl.obolibrary.org/obo/GO_0004497

Removed

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161795"

  • label "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161814"

  • label "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161940"

  • label "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-6786239"

  • label "CYP4V2 omega-hydroxylates DHA to HDoHE"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161890"

  • label "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161899"

  • label "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2162191"

  • label "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-211951"

  • label "CYP1B1 4-hydroxylates EST17b"

Added

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161940"

  • label "Arachidonate is hydroxylated to 20-HETE by CYP(3)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161890"

  • label "Arachidonate is epoxidated to 5,6-EET by CYP(4)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-9915997"

  • label "Arachidonate is epoxidated to 14,15-EET by CYP(5)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-9915971"

  • label "Arachidonate is epoxidated to 11,12-EET by CYP(5)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161899"

  • label "Arachidonate is epoxidated to 8,9-EET by CYP(5)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-9915992"

  • label "Arachidonate is hydroxylated to 17-HETE by CYP(1)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-9915993"

  • label "Arachidonate is hydroxylated to 18-HETE by CYP(1)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161795"

  • label "Arachidonate is hydroxylated to 16-HETE by CYP(1)"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2162191"

  • label "Unknown enzyme hydroxylates DMPhOH"

• monooxygenase activity database_cross_reference "Reactome:R-HSA-2161814"

  • label "Arachidonate is hydroxylated to 19-HETE by CYP(2)"

nitric oxide dioxygenase NAD(P)H activity http://purl.obolibrary.org/obo/GO_0008941

Removed

• nitric oxide dioxygenase NAD(P)H activity database_cross_reference "Reactome:R-HSA-5340226"
  • label "CYGB dioxygenates NO"

nitric-oxide synthase inhibitor activity http://purl.obolibrary.org/obo/GO_0036487

Added

• nitric-oxide synthase inhibitor activity database_cross_reference "Reactome:R-HSA-203712"
  • label "eNOS associates with Caveolin-1"

nitric-oxide synthase regulator activity http://purl.obolibrary.org/obo/GO_0030235

Added

• nitric-oxide synthase regulator activity database_cross_reference "Reactome:R-HSA-202129"

  • label "HSP90 binds eNOS:Caveolin-1:CaM complex"

• nitric-oxide synthase regulator activity database_cross_reference "Reactome:R-HSA-202144"

  • label "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex"

obsolete 13-prostaglandin reductase activity http://purl.obolibrary.org/obo/GO_0036132

Removed

• obsolete 13-prostaglandin reductase activity database_cross_reference "Reactome:R-HSA-2161692"
  • label "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1"

obsolete 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity http://purl.obolibrary.org/obo/GO_0043430

Removed

• obsolete 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity database_cross_reference "Reactome:R-HSA-2162188"
  • label "MDMQ10H2 is methylated to DMQ10H2 by COQ5"

obsolete 3-demethylubiquinol-10 3-O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0044596

Removed

• obsolete 3-demethylubiquinol-10 3-O-methyltransferase activity database_cross_reference "Reactome:R-HSA-2162186"
  • label "DeMQ10H2 is methylated to Q10H2 by COQ3"

obsolete 4-hydroxybenzoate decaprenyltransferase activity http://purl.obolibrary.org/obo/GO_0002083

Removed

• obsolete 4-hydroxybenzoate decaprenyltransferase activity database_cross_reference "Reactome:R-HSA-2162192"
  • label "PHB and all-E-10PrP2 are combined into DHB by COQ2"

Added

• obsolete 4-hydroxybenzoate decaprenyltransferase activity database_cross_reference "Reactome:R-HSA-2162192"
  • label "COQ2 ligates all-E-10PrP2 to PHB"

obsolete DNA-N1-methyladenine dioxygenase activity http://purl.obolibrary.org/obo/GO_0043734

Removed

• obsolete DNA-N1-methyladenine dioxygenase activity database_cross_reference "Reactome:R-HSA-112118"

  • label "Oxidative demethylation of 1-meA damaged DNA by ALKBH2"

• obsolete DNA-N1-methyladenine dioxygenase activity database_cross_reference "Reactome:R-HSA-112123"

  • label "Oxidative demethylation of 1-meA damaged DNA By ALKBH3"

obsolete N-acylsphingosine galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0047263

Removed

• obsolete N-acylsphingosine galactosyltransferase activity database_cross_reference "Reactome:R-HSA-6785933"
  • label "UGT8 transfers Gal from UDP-Gal to CERA"

obsolete NAD glycohydrolase activity http://purl.obolibrary.org/obo/GO_0061810

Removed

• obsolete NAD glycohydrolase activity database_cross_reference "Reactome:R-HSA-9637699"
  • label "CpnT hydrolyses NAD+"

obsolete NAD(P)+ transhydrogenase activity http://purl.obolibrary.org/obo/GO_0008746

Removed

• obsolete NAD(P)+ transhydrogenase activity database_cross_reference "Reactome:R-HSA-450971"
  • label "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]"

obsolete acid-sensing ion channel activity http://purl.obolibrary.org/obo/GO_0044736

Removed

• obsolete acid-sensing ion channel activity database_cross_reference "Reactome:R-HSA-2671885"
  • label "ASIC trimers:H+ transport extracellular Na+ to cytosol"

obsolete alcohol dehydrogenase (NAD+) activity, zinc-dependent http://purl.obolibrary.org/obo/GO_0004024

Removed

• obsolete alcohol dehydrogenase (NAD+) activity, zinc-dependent database_cross_reference "Reactome:R-HSA-71707"
  • label "ethanol + NAD+ => acetaldehyde + NADH + H+"

obsolete butyrate-CoA ligase activity http://purl.obolibrary.org/obo/GO_0047760

Removed

• obsolete butyrate-CoA ligase activity database_cross_reference "Reactome:R-HSA-8875013"
  • label "ACSM3,ACSM6 ligate CoA to BUT"

obsolete decaprenyldihydroxybenzoate methyltransferase activity http://purl.obolibrary.org/obo/GO_0044595

Removed

• obsolete decaprenyldihydroxybenzoate methyltransferase activity database_cross_reference "Reactome:R-HSA-2162193"
  • label "DHDB is methylated to MHDB by COQ3"

obsolete sterol transporter activity http://purl.obolibrary.org/obo/GO_0015248

Removed

• obsolete sterol transporter activity database_cross_reference "Reactome:R-HSA-5679145"

  • label "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region"

• obsolete sterol transporter activity database_cross_reference "Reactome:R-HSA-5679101"

  • label "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region"

• obsolete sterol transporter activity database_cross_reference "Reactome:R-HSA-8868402"

  • label "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane"

• obsolete sterol transporter activity database_cross_reference "Reactome:R-HSA-5250531"

  • label "ARV1 transports CHOL from ER membrane to plasma membrane"

• obsolete sterol transporter activity database_cross_reference "Reactome:R-HSA-265783"

  • label "ABCG5:ABCG8 transports sterols from cytosol to extracellular region"

• obsolete sterol transporter activity database_cross_reference "Reactome:R-HSA-8867667"

  • label "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane"

obsolete tRNA (guanosine-2'-O-)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0009020

Removed

• obsolete tRNA (guanosine-2'-O-)-methyltransferase activity database_cross_reference "Reactome:R-HSA-9024161"
  • label "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe)"

obsolete tRNA (uracil-2'-O-)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0052665

Removed

• obsolete tRNA (uracil-2'-O-)-methyltransferase activity database_cross_reference "Reactome:R-HSA-6788707"
  • label "TRMT44 2'-O-methylates uridine-44 in tRNA(Ser)"

organic cyclic compound binding http://purl.obolibrary.org/obo/GO_0097159

Added

• organic cyclic compound binding database_cross_reference "Reactome:R-HSA-1497796"
  • label "BH2 binding can lead to eNOS uncoupling"

oxaloacetate decarboxylase activity http://purl.obolibrary.org/obo/GO_0008948

Removed

• oxaloacetate decarboxylase activity database_cross_reference "Reactome:R-HSA-9012016"
  • label "FAHD1:Zn2+ dimer hydrolyses OA to PYR"

Added

• oxaloacetate decarboxylase activity database_cross_reference "Reactome:R-HSA-9861660"

  • label "ME1 tetramer decarboxylates OA to PYR"

• oxaloacetate decarboxylase activity database_cross_reference "Reactome:R-HSA-9012016"

  • label "FAHD1 dimer hydrolyses OA to PYR"

oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016491

Removed

• oxidoreductase activity database_cross_reference "Reactome:R-HSA-3095889"

  • label "MMACHC dealkylates RCbl"

• oxidoreductase activity database_cross_reference "Reactome:R-HSA-9020260"

  • label "Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5"

Added

• oxidoreductase activity database_cross_reference "Reactome:R-HSA-9759549"

  • label "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin"

• oxidoreductase activity database_cross_reference "Reactome:R-HSA-9020260"

  • label "Hydroperoxy reductase reduces 7(S)-Hp-17(S)-HDHA to RvD5"

• oxidoreductase activity database_cross_reference "Reactome:R-HSA-265296"

  • label "Arachidonate is oxidised to 5S-HpETE by ALOX5"

• oxidoreductase activity database_cross_reference "Reactome:R-HSA-2161612"

  • label "PGH2 is reduced to PGF2a by FAM213B"

• oxidoreductase activity database_cross_reference "Reactome:R-HSA-266051"

  • label "5S-HpETE is dehydrated to LTA4 by ALOX5"

oxidoreductase activity, acting on a heme group of donors http://purl.obolibrary.org/obo/GO_0016675

Added

• oxidoreductase activity, acting on a heme group of donors database_cross_reference "Reactome:R-HSA-5340226"
  • label "CYGB dioxygenates NO"

oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016723

Removed

• oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor database_cross_reference "Reactome:R-HSA-917811"
  • label "STEAP3-like proteins reduce Fe3+ to Fe2+"

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0016709

Removed

• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen database_cross_reference "Reactome:R-HSA-2162194"

  • label "COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2"

• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen database_cross_reference "Reactome:R-HSA-2162187"

  • label "DHB is hydroxylated to DHDB by COQ6"

Added

• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen database_cross_reference "Reactome:R-HSA-2162187"

  • label "COQ6 hydroxylates DHB"

• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen database_cross_reference "Reactome:R-HSA-2162194"

  • label "COQ7:COQ9 octamer hydroxylates DMQ10H2"

• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen database_cross_reference "Reactome:R-HSA-211951"

  • label "CYP1B1 4-hydroxylates EST17b"

• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen database_cross_reference "Reactome:R-HSA-6786239"

  • label "CYP4V2 omega-hydroxylates DHA to HDoHE"

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0016712

Added

• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen database_cross_reference "Reactome:R-HSA-194678"
  • label "CYP51A1 demethylates LNSOL"

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen http://purl.obolibrary.org/obo/GO_0016701

Added

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9027628"

  • label "ALOX5 oxidises EPA to 5-HEPE"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9020251"

  • label "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9020278"

  • label "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9018858"

  • label "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9020282"

  • label "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9027624"

  • label "ALOX5 oxidises DHA to 7-HDHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9018894"

  • label "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9020261"

  • label "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9027607"

  • label "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-2161951"

  • label "Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9026405"

  • label "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9018863"

  • label "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9025995"

  • label "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9018859"

  • label "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9025999"

  • label "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9020264"

  • label "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9024997"

  • label "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9027627"

  • label "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9020256"

  • label "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9025996"

  • label "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9027633"

  • label "ALOX5 oxidises DPAn-3 to 7-HDPAn-3"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9020259"

  • label "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9026005"

  • label "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9028255"

  • label "PTGS2 dimer oxidises EPA to PGH3"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9027532"

  • label "PTGS2 dimer oxidises DHA to 13-HDHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9020255"

  • label "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen database_cross_reference "Reactome:R-HSA-9020277"

  • label "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA"

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen http://purl.obolibrary.org/obo/GO_0016702

Removed

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen database_cross_reference "Reactome:R-HSA-2161775"
  • label "ALOX12 oxidises LTA4 to LXA4/B4"

Added

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen database_cross_reference "Reactome:R-HSA-9916401"

  • label "ALOX12 oxidises LTA4 to LXB4"

• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen database_cross_reference "Reactome:R-HSA-2161775"

  • label "ALOX12 oxidises LTA4 to LXA4"

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016616

Added

• oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor database_cross_reference "Reactome:R-HSA-9027625"

  • label "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3"

• oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor database_cross_reference "Reactome:R-HSA-9027632"

  • label "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA"

• oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor database_cross_reference "Reactome:R-HSA-9027631"

  • label "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA"

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor http://purl.obolibrary.org/obo/GO_0016624

Added

• oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor database_cross_reference "Reactome:R-HSA-9859148"

  • label "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV"

• oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor database_cross_reference "Reactome:R-HSA-9858321"

  • label "DHTKD1 dimer decarboxylates 2-OA"

• oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor database_cross_reference "Reactome:R-HSA-9865121"

  • label "BCKDHA or BCKDHB loss-of-function mutants don't synthesize BCAA-CoA"

oxoglutarate dehydrogenase (NAD+) activity http://purl.obolibrary.org/obo/GO_0034602

Removed

• oxoglutarate dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-71037"

  • label "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+"

• oxoglutarate dehydrogenase (NAD+) activity database_cross_reference "Reactome:R-HSA-71401"

  • label "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+"

oxoglutarate dehydrogenase (succinyl-transferring) activity http://purl.obolibrary.org/obo/GO_0004591

Added

• oxoglutarate dehydrogenase (succinyl-transferring) activity database_cross_reference "Reactome:R-HSA-71401"
  • label "OGDH dimer decarboxylates 2-OG"

oxoglutarate:malate antiporter activity http://purl.obolibrary.org/obo/GO_0015367

Removed

• oxoglutarate:malate antiporter activity database_cross_reference "Reactome:R-HSA-376851"
  • label "SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane"

Added

• oxoglutarate:malate antiporter activity database_cross_reference "Reactome:R-HSA-376851"
  • label "SLC25A11 exchanges 2-OG and MAL"

pH-gated monoatomic ion channel activity http://purl.obolibrary.org/obo/GO_0160128

Added

• pH-gated monoatomic ion channel activity database_cross_reference "Reactome:R-HSA-2671885"
  • label "ASIC trimers:H+ transport extracellular Na+ to cytosol"

palmitoyl-(protein) hydrolase activity http://purl.obolibrary.org/obo/GO_0008474

Removed

• palmitoyl-(protein) hydrolase activity database_cross_reference "Reactome:R-HSA-203613"
  • label "depalmitoylation of eNOS"

Added

• palmitoyl-(protein) hydrolase activity database_cross_reference "Reactome:R-HSA-203613"
  • label "Depalmitoylation of eNOS"

palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0016409

Removed

• palmitoyltransferase activity database_cross_reference "Reactome:R-HSA-203567"
  • label "palmitoylation of eNOS"

passive transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022803

Removed

• passive transmembrane transporter activity database_cross_reference "Reactome:R-HSA-429767"
  • label "Passive I- efflux mediated by SMCT1"

peptide-lysine-N-acetyltransferase activity http://purl.obolibrary.org/obo/GO_0061733

Added

• peptide-lysine-N-acetyltransferase activity database_cross_reference "Reactome:R-HSA-9825747"
  • label "CREBBP acetylates HINT1 dimer"

peptide:proton symporter activity http://purl.obolibrary.org/obo/GO_0015333

Removed

• peptide:proton symporter activity database_cross_reference "Reactome:R-HSA-427998"
  • label "Proton-coupled di- and tri-peptide cotransport"

Added

• peptide:proton symporter activity database_cross_reference "Reactome:R-HSA-427998"
  • label "SLC25A1 transports di-/tri-peptides and peptide-like drugs"

phosphatidylcholine transfer activity http://purl.obolibrary.org/obo/GO_0120019

Added

• phosphatidylcholine transfer activity database_cross_reference "Reactome:R-HSA-1483211"

  • label "PC:PITPNB is transported from the Golgi membrane to the ER membrane"

• phosphatidylcholine transfer activity database_cross_reference "Reactome:R-HSA-1483087"

  • label "PI is exchanged with PC by PITPNB"

• phosphatidylcholine transfer activity database_cross_reference "Reactome:R-HSA-1483219"

  • label "PC is exchanged with PI by PITPNB"

phosphatidylinositol transfer activity http://purl.obolibrary.org/obo/GO_0008526

Added

• phosphatidylinositol transfer activity database_cross_reference "Reactome:R-HSA-1483229"
  • label "PI:PITPNB is transported from the ER membrane to the Golgi membrane"

phospholipase activator activity http://purl.obolibrary.org/obo/GO_0016004

Added

• phospholipase activator activity database_cross_reference "Reactome:R-HSA-400023"
  • label "Gq alpha activates Phospholipase C beta"

phosphomevalonate kinase activity http://purl.obolibrary.org/obo/GO_0004631

Removed

• phosphomevalonate kinase activity database_cross_reference "Reactome:R-HSA-191422"
  • label "Mevalonate-5-phosphate is further phosphorylated."

Added

• phosphomevalonate kinase activity database_cross_reference "Reactome:R-HSA-191422"
  • label "Mevalonate-5-phosphate is further phosphorylated"

phosphoprotein phosphatase activity http://purl.obolibrary.org/obo/GO_0004721

Removed

• phosphoprotein phosphatase activity database_cross_reference "Reactome:R-HSA-9636684"
  • label "ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP"

Added

• phosphoprotein phosphatase activity database_cross_reference "Reactome:R-HSA-9636684"
  • label "NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP"

procollagen galactosyltransferase activity http://purl.obolibrary.org/obo/GO_0050211

Removed

• procollagen galactosyltransferase activity database_cross_reference "Reactome:R-HSA-1981120"
  • label "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2."

Added

• procollagen galactosyltransferase activity database_cross_reference "Reactome:R-HSA-1981120"
  • label "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2"

progesterone 21-hydroxylase activity http://purl.obolibrary.org/obo/GO_0106309

Added

• progesterone 21-hydroxylase activity database_cross_reference "Reactome:R-HSA-193964"

  • label "CYP21A2 21-hydroxylates PROG"

• progesterone 21-hydroxylase activity database_cross_reference "Reactome:R-HSA-193981"

  • label "CYP21A2 oxidises 17HPROG"

prostaglandin transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015132

Added

• prostaglandin transmembrane transporter activity database_cross_reference "Reactome:R-HSA-9032327"
  • label "5-oxo-EPA, 15d-PGJ3 translocate from cytosol to extracellular region"

prostaglandin-endoperoxide synthase activity http://purl.obolibrary.org/obo/GO_0004666

Removed

• prostaglandin-endoperoxide synthase activity database_cross_reference "Reactome:R-HSA-2309787"

  • label "Arachidonic acid is oxidised to PGG2 by PTGS2"

• prostaglandin-endoperoxide synthase activity database_cross_reference "Reactome:R-HSA-140355"

  • label "Arachidonic acid is oxidised to PGG2 by PTGS1"

Added

• prostaglandin-endoperoxide synthase activity database_cross_reference "Reactome:R-HSA-140355"

  • label "Arachidonate is oxidised to PGG2 by PTGS1"

• prostaglandin-endoperoxide synthase activity database_cross_reference "Reactome:R-HSA-2309787"

  • label "Arachidonate is oxidised to PGG2 by PTGS2"

protein binding http://purl.obolibrary.org/obo/GO_0005515

Added

• protein binding database_cross_reference "Reactome:R-HSA-9866132"
  • label "Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH"

protein folding chaperone http://purl.obolibrary.org/obo/GO_0044183

Added

• protein folding chaperone database_cross_reference "Reactome:R-HSA-9855212"

  • label "SDHA binds to SDHB"

• protein folding chaperone database_cross_reference "Reactome:R-HSA-9866253"

  • label "apo-UQCRFS1 binds LYRM7"

• protein folding chaperone database_cross_reference "Reactome:R-HSA-9865893"

  • label "MT-CYB is translated"

protein lysine deacetylase activity http://purl.obolibrary.org/obo/GO_0033558

Added

• protein lysine deacetylase activity database_cross_reference "Reactome:R-HSA-9841847"

  • label "SIRT3 deacetylates Ac-K272,K290-FOXO3"

• protein lysine deacetylase activity database_cross_reference "Reactome:R-HSA-9825772"

  • label "SIRT1 deacetylates HINT1 dimer"

protein serine kinase activity http://purl.obolibrary.org/obo/GO_0106310

Added

• protein serine kinase activity database_cross_reference "Reactome:R-HSA-9860792"

  • label "Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177"

• protein serine kinase activity database_cross_reference "Reactome:R-HSA-9860808"

  • label "p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179"

• protein serine kinase activity database_cross_reference "Reactome:R-HSA-9841265"

  • label "p-S473-AKT1 phosphorylates ESR1 on serine-167"

protein serine/threonine kinase activity http://purl.obolibrary.org/obo/GO_0004674

Removed

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-451347"

  • label "Activation of JNK by DSCAM"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-450827"

  • label "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2."

Added

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9860785"

  • label "PDPK1 (PDK1) phosphorylates PKN2 on threonine-816"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9824977"

  • label "MAPK1-dependent phosphorylation of MITF-M"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9825704"

  • label "AKT3 phosphorylates TBX3"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9851972"

  • label "PLK1 phosphorylates FIRRM at S43"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9834076"

  • label "PINK1 is autophosphorylated"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9855910"

  • label "USF1 is phosphorylated by p-MAPK14"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-202111"

  • label "AKT1 phosphorylates eNOS"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9824999"

  • label "GSK3B phosphorylates p-S73 MITF-M at residue S69"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9839363"

  • label "TGFBR3 phosphorylation by TGFBR2 complex"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-450827"

  • label "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9834945"

  • label "PINK1 phosphorylates Ub on MOM proteins"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9860292"

  • label "Activated IKBKB phosphorylates IRF5"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9860800"

  • label "mTORC2 phosphorylates AKT1 on serine-473"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9835011"

  • label "PINK1 phosphorylates PRKN at S65"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9853369"

  • label "PLK1 phosphorylates FIRMM at S744"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9824897"

  • label "p-S-TBK1 phosphorylates OPTN"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9861642"

  • label "NEK1 phosphorylates ME1"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9824995"

  • label "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9824994"

  • label "RPS6KA1-dependent phosphorylation of MITF-M"

• protein serine/threonine kinase activity database_cross_reference "Reactome:R-HSA-9824582"

  • label "MAPK1 phosphorylates SOX10"

protein serine/threonine phosphatase activity http://purl.obolibrary.org/obo/GO_0004722

Added

• protein serine/threonine phosphatase activity database_cross_reference "Reactome:R-HSA-9861725"

  • label "PGAM5 dodecamer dephosphorylates p-S336-ME1"

• protein serine/threonine phosphatase activity database_cross_reference "Reactome:R-HSA-9865226"

  • label "PP2A dephosphorylates serine-127 of YAP1"

• protein serine/threonine phosphatase activity database_cross_reference "Reactome:R-HSA-9865238"

  • label "PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin"

• protein serine/threonine phosphatase activity database_cross_reference "Reactome:R-HSA-9853385"

  • label "PPP1CC dephosphorylates PLK1"

• protein serine/threonine phosphatase activity database_cross_reference "Reactome:R-HSA-9912527"

  • label "H139Hfs13* PPM1K does not dephosphorylate BCKDH"

protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0004713

Added

• protein tyrosine kinase activity database_cross_reference "Reactome:R-HSA-9865196"

  • label "p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1"

• protein tyrosine kinase activity database_cross_reference "Reactome:R-HSA-9861469"

  • label "p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)"

• protein tyrosine kinase activity database_cross_reference "Reactome:R-HSA-9842667"

  • label "CLIP1-LTK fusion autophosphorylates"

• protein tyrosine kinase activity database_cross_reference "Reactome:R-HSA-9860500"

  • label "Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1"

• protein tyrosine kinase activity database_cross_reference "Reactome:R-HSA-9842651"

  • label "Active LTK receptor phosphorylates SHC1"

• protein tyrosine kinase activity database_cross_reference "Reactome:R-HSA-9842648"

  • label "Autophosphorylation of LTK dimer:ALKAL1,2"

• protein tyrosine kinase activity database_cross_reference "Reactome:R-HSA-9860759"

  • label "p-T816-PKN2 phosphorylates AKT1 on serine-308"

• protein tyrosine kinase activity database_cross_reference "Reactome:R-HSA-9841924"

  • label "ABL1 phosphorylates PPARG2"

• protein tyrosine kinase activity database_cross_reference "Reactome:R-HSA-9842666"

  • label "Active LTK phosphorylates IRS1"

protein tyrosine phosphatase activity http://purl.obolibrary.org/obo/GO_0004725

Added

• protein tyrosine phosphatase activity database_cross_reference "Reactome:R-HSA-9865167"
  • label "PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)"

protein-cysteine S-palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0019706

Added

• protein-cysteine S-palmitoyltransferase activity database_cross_reference "Reactome:R-HSA-203567"
  • label "Palmitoylation of eNOS"

protein-lysine N-methyltransferase activity http://purl.obolibrary.org/obo/GO_0016279

Added

• protein-lysine N-methyltransferase activity database_cross_reference "Reactome:R-HSA-9854315"

  • label "CSKMT methylates Citrate Synthase"

• protein-lysine N-methyltransferase activity database_cross_reference "Reactome:R-HSA-9844111"

  • label "EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP"

proton transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015078

Removed

• proton transmembrane transporter activity database_cross_reference "Reactome:R-HSA-170026"
  • label "Protons are translocated from the intermembrane space to the matrix"

Added

• proton transmembrane transporter activity database_cross_reference "Reactome:R-HSA-170026"

  • label "UCP1 imports a proton"

• proton transmembrane transporter activity database_cross_reference "Reactome:R-HSA-9864415"

  • label "AAC1 imports a proton"

pyruvate carboxylase activity http://purl.obolibrary.org/obo/GO_0004736

Removed

• pyruvate carboxylase activity database_cross_reference "Reactome:R-HSA-70501"
  • label "PC catalyzes the carboxylation of PYR to form OA"

Added

• pyruvate carboxylase activity database_cross_reference "Reactome:R-HSA-70501"
  • label "PC carboxylates PYR to OA"

pyruvate dehydrogenase (acetyl-transferring) activity http://purl.obolibrary.org/obo/GO_0004739

Added

• pyruvate dehydrogenase (acetyl-transferring) activity database_cross_reference "Reactome:R-HSA-9861734"
  • label "PDH E1 decarboxylates PYR, transferring acetyl to DLAT"

pyruvate dehydrogenase (acetyl-transferring) kinase activity http://purl.obolibrary.org/obo/GO_0004740

Removed

• pyruvate dehydrogenase (acetyl-transferring) kinase activity database_cross_reference "Reactome:R-HSA-203946"
  • label "PDK isoforms phosphorylate lipo-PDH"

Added

• pyruvate dehydrogenase (acetyl-transferring) kinase activity database_cross_reference "Reactome:R-HSA-203946"
  • label "PDK isozymes phosphorylate PDHC subunit E1"

pyruvate dehydrogenase activity http://purl.obolibrary.org/obo/GO_0004738

Removed

• pyruvate dehydrogenase activity database_cross_reference "Reactome:R-HSA-71397"
  • label "lipo-PDH decarboxylates PYR to Ac-CoA"

pyruvate kinase activity http://purl.obolibrary.org/obo/GO_0004743

Removed

• pyruvate kinase activity database_cross_reference "Reactome:R-HSA-71670"
  • label "phosphoenolpyruvate + ADP => pyruvate + ATP"

Added

• pyruvate kinase activity database_cross_reference "Reactome:R-HSA-71670"
  • label "PKM dephosphorylates PEP to PYR"

pyruvate transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0050833

Removed

• pyruvate transmembrane transporter activity database_cross_reference "Reactome:R-HSA-372342"
  • label "MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix"

Added

• pyruvate transmembrane transporter activity database_cross_reference "Reactome:R-HSA-372342"
  • label "MPC1:MPC2 imports PYR, H+ to mitochondrial matrix"

receptor ligand activity http://purl.obolibrary.org/obo/GO_0048018

Added

• receptor ligand activity database_cross_reference "Reactome:R-HSA-163625"

  • label "Glucagon binds to Glucagon receptor"

• receptor ligand activity database_cross_reference "Reactome:R-HSA-381612"

  • label "GLP1R binds GLP1"

ryanodine-sensitive calcium-release channel activity http://purl.obolibrary.org/obo/GO_0005219

Removed

• ryanodine-sensitive calcium-release channel activity database_cross_reference "Reactome:R-HSA-2855020"
  • label "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol"

sepiapterin reductase (NADP+) activity http://purl.obolibrary.org/obo/GO_0004757

Removed

• sepiapterin reductase (NADP+) activity database_cross_reference "Reactome:R-HSA-1497869"
  • label "Salvage - Sepiapterin is reduced to BH2"

Added

• sepiapterin reductase (NADP+) activity database_cross_reference "Reactome:R-HSA-1497869"
  • label "Salvage - Sepiapterin is reduced to q-BH2"

serine-type endopeptidase activity http://purl.obolibrary.org/obo/GO_0004252

Removed

• serine-type endopeptidase activity database_cross_reference "Reactome:R-HSA-1454843"
  • label "E-cadherin degradation by MMP3, MMP7 and plasmin."

Added

• serine-type endopeptidase activity database_cross_reference "Reactome:R-HSA-9839367"

  • label "TGFBR3_mem cleavage by MMPs"

• serine-type endopeptidase activity database_cross_reference "Reactome:R-HSA-1454843"

  • label "E-cadherin degradation by MMP3, MMP7 and plasmin"

sphingosine-1-phosphate phosphatase activity http://purl.obolibrary.org/obo/GO_0042392

Added

• sphingosine-1-phosphate phosphatase activity database_cross_reference "Reactome:R-HSA-428664"
  • label "SGPP1,2 dephosphorylate sphingoid-1-phosphates"

steroid 21-monooxygenase activity http://purl.obolibrary.org/obo/GO_0004509

Removed

• steroid 21-monooxygenase activity database_cross_reference "Reactome:R-HSA-193964"

  • label "CYP21A2 21-hydroxylates PROG"

• steroid 21-monooxygenase activity database_cross_reference "Reactome:R-HSA-193981"

  • label "CYP21A2 oxidises 17HPROG"

sterol 14-demethylase activity http://purl.obolibrary.org/obo/GO_0008398

Removed

• sterol 14-demethylase activity database_cross_reference "Reactome:R-HSA-194678"
  • label "CYP51A1 demethylates LNSOL"

sterol transfer activity http://purl.obolibrary.org/obo/GO_0120015

Added

• sterol transfer activity database_cross_reference "Reactome:R-HSA-8867667"

  • label "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane"

• sterol transfer activity database_cross_reference "Reactome:R-HSA-8868402"

  • label "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane"

• sterol transfer activity database_cross_reference "Reactome:R-HSA-5250531"

  • label "ARV1 transports CHOL from ER membrane to plasma membrane"

succinate dehydrogenase (quinone) activity http://purl.obolibrary.org/obo/GO_0008177

Removed

• succinate dehydrogenase (quinone) activity database_cross_reference "Reactome:R-HSA-70994"
  • label "Succinate <=> Fumarate (with FAD redox reaction on enzyme)"

Added

• succinate dehydrogenase (quinone) activity database_cross_reference "Reactome:R-HSA-70994"
  • label "SDH complex dehydrogenates succinate"

succinate-CoA ligase (ADP-forming) activity http://purl.obolibrary.org/obo/GO_0004775

Removed

• succinate-CoA ligase (ADP-forming) activity database_cross_reference "Reactome:R-HSA-70997"
  • label "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA"

Added

• succinate-CoA ligase (ADP-forming) activity database_cross_reference "Reactome:R-HSA-70997"
  • label "SUCLG1/A2 cleaves succinyl-CoA"

succinate-CoA ligase (GDP-forming) activity http://purl.obolibrary.org/obo/GO_0004776

Removed

• succinate-CoA ligase (GDP-forming) activity database_cross_reference "Reactome:R-HSA-71775"
  • label "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA"

Added

• succinate-CoA ligase (GDP-forming) activity database_cross_reference "Reactome:R-HSA-71775"
  • label "SUCLG1/G2 cleaves succinyl-CoA"

tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0106340

Added

• tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity database_cross_reference "Reactome:R-HSA-9024161"
  • label "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe)"

tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity http://purl.obolibrary.org/obo/GO_0141101

Added

• tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity database_cross_reference "Reactome:R-HSA-6788707"
  • label "TRMT44 2'-O-methylates uridine-44 in tRNA(Ser)"

tetrahydrobiopterin binding http://purl.obolibrary.org/obo/GO_0034617

Added

• tetrahydrobiopterin binding database_cross_reference "Reactome:R-HSA-1497784"
  • label "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle"

thioredoxin peroxidase activity http://purl.obolibrary.org/obo/GO_0008379

Removed

• thioredoxin peroxidase activity database_cross_reference "Reactome:R-HSA-2161612"
  • label "PGH2 is reduced to PGF2a by FAM213B"

trans-2-enoyl-CoA reductase (NADPH) activity http://purl.obolibrary.org/obo/GO_0019166

Removed

• trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference "Reactome:R-HSA-6786720"
  • label "DECR2 reduces LCtE-CoA to t3enoyl-CoA"

Added

• trans-2-enoyl-CoA reductase (NADPH) activity database_cross_reference "Reactome:R-HSA-6786720"
  • label "DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoA"

transferase activity, transferring alkyl or aryl (other than methyl) groups http://purl.obolibrary.org/obo/GO_0016765

Removed

• transferase activity, transferring alkyl or aryl (other than methyl) groups database_cross_reference "Reactome:R-HSA-3159253"
  • label "MMAB adenosylates cob(I)alamin"

Added

• transferase activity, transferring alkyl or aryl (other than methyl) groups database_cross_reference "Reactome:R-HSA-3095889"
  • label "MMACHC dealkylates RCbl"

tricarboxylic acid transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015142

Removed

• tricarboxylic acid transmembrane transporter activity database_cross_reference "Reactome:R-HSA-75849"
  • label "Transport of Citrate from Mitochondrial Matrix to cytosol"

Added

• tricarboxylic acid transmembrane transporter activity database_cross_reference "Reactome:R-HSA-75849"
  • label "SLC25A1 exchanges CIT and MAL"

ubiquitin protein ligase activity http://purl.obolibrary.org/obo/GO_0061630

Removed

• ubiquitin protein ligase activity database_cross_reference "Reactome:R-HSA-9008479"
  • label "FBXW7 polyubiquitinates RUNX2"

ubiquitin-protein transferase activity http://purl.obolibrary.org/obo/GO_0004842

Removed

• ubiquitin-protein transferase activity database_cross_reference "Reactome:R-HSA-5205682"
  • label "Parkin promotes the ubiquitination of mitochondrial substrates"

Added

• ubiquitin-protein transferase activity database_cross_reference "Reactome:R-HSA-9861563"

  • label "CTLH E3 ligase ubiquitinates LDHA"

• ubiquitin-protein transferase activity database_cross_reference "Reactome:R-HSA-9834070"

  • label "PRKN ubiquitinates MOM substrates"

• ubiquitin-protein transferase activity database_cross_reference "Reactome:R-HSA-9861640"

  • label "CTLH E3 ligase ubiquitinates PKM-1"

uroporphyrinogen decarboxylase activity http://purl.obolibrary.org/obo/GO_0004853

Removed

• uroporphyrinogen decarboxylase activity database_cross_reference "Reactome:R-HSA-189425"

  • label "UROD decarboxylates URO3 to COPRO3"

• uroporphyrinogen decarboxylase activity database_cross_reference "Reactome:R-HSA-190182"

  • label "UROD decarboxylates URO1 to COPRO1"

very long-chain fatty acid-CoA ligase activity http://purl.obolibrary.org/obo/GO_0031957

Added

• very long-chain fatty acid-CoA ligase activity database_cross_reference "Reactome:R-HSA-9914143"
  • label "SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH"