NTR: G-quadruplex unwinding activity

[raymond91125]

Please provide as much information as you can:

• Suggested term label:

• G-quadroplex unwinding activity

• Definition:

• Unwinding G-quadruplex structures in nucleic acids, DNA or RNA.

• Reference, in format PMID:####### PMID:26883636 PMID:1324186 PMID:34113828

• Gene product name and ID to be annotated to this term Pif1 DHX36 RPA1

• Parent term(s) GO:0140640 catalytic activity, acting on a nucleic acid

• Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

• Synonyms (please specify, EXACT, BROAD, NARROW or RELATED) G4 unwinding activity (EXACT) G-quadruplex resolving activity (EXACT)

• Cross-references

• For enzymes, please provide RHEA and/or EC numbers.

• Can also provide MetaCyc, KEGG, Wikipedia, and other links.

• Any other information

[raymond91125]

https://github.com/geneontology/go-annotation/issues/5540 @ValWood Is this good? RPA1 seems to break the typical helicase classification.

[ValWood]

add definition gloss " A DNA quadruplex (or G-quadruplex), is a specialized structure formed in DNA/RNA when sequences rich in guanine (G) assemble into a unique four-stranded arrangement."

[ValWood]

Sounds good. Good point that it isn't a helix!