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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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Translation activator activity #29317

Open Antonialock opened 1 day ago

Antonialock commented 1 day ago

Translation activator activity is a direct child of translation regulator, nucleic acid binding, whereas the repressor activity is a direct child of translation regulator

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I wonder if something can be an activator without binding the RNA. For example cbp7/8 / sls1/mtf2/ppr4/mrh5 in the model below PMID: 34634819

@ValWood

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Figure 12. Model of the cooperative interplay between ribosomal isoforms and translational activators to localize and coordinate synthesis and assembly of OXPHOS subunits. Translational activators of cytb and cox1, Cbp7/8 and Mrh5/Ppr4/Mtf2/Sls1 respectively, could preferentially interact with either Mug178 or Mrp51 ribosomes, the translated mRNA and the membrane, in order to localize Cytb and Cox1 synthesis into the sub-regions optimal for subsequent assembly. Similarly, cox3 translation initiation would be favored on Mug178-containing SSU. Mrp51 ribosomes are proposed to synthesize most of the other proteins, including a low amount of Cox3 protein, maybe through translation of the bi-cistronic cox1-cox3 mRNA. Small (SSU) and large (LSU) ribosomal subunits have been indicated.

ValWood commented 1 day ago

Agreed. See https://github.com/geneontology/go-ontology/issues/29089 and add anything additional to this ticket. v