NTR: Pos Reg of p53 induced by DNA damage response

[gocentral]

positive regulation of DNA damage response, signal transduction by p53 class mediator

or (preferably)

positive regulation of p53 induced by DNA damage response

--- Proposed Locations ----

PROCESS

GO:0030330 DNA damage response, signal transduction by p53 class mediator > GO: positive regulation of p53 induced by DNA damage response > GO: negative regulation of p53 induced by DNA damage response

--- Proposed Defs ---

* positive regulation of p53 induced by DNA damage response Any process that activates or increases the rate, frequency or extent of p53 in response to DNA damage

* negative regulation of p53 induced by DNA damage response Any process that stops, prevents or reduces the rate, frequency or extent of p53 in response to DNA damage

--- Refs ---

GO:0030330 DNA damage response, signal transduction by p53 class mediator Def: A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.

"All of these results support the idea that p18 is critical for the DNA damage-dependent induction of p53." Bum-Joon et al 2005 The Haploinsufficient Tumor Suppressor p18 Upregulates p53 via Interactions with ATM/ATR. Cell. http://www.sciencedirect.com/science?\_ob=ArticleURL&\_udi=B6WSN-4FBP691-B&\_coverDate=01%2F28%2F2005&\_alid=327885259&\_rdoc=1&\_fmt=&\_orig=search&\_qd=1&\_cdi=7051&\_sort=d&view=c&\_acct=C000042238&\_version=1&\_urlVersion=0&\_userid=776054&md5=0f442cead63287267cae0c6e9f6bf6e4

--- My Ref --- O43324 - MCA3_HUMAN

Reported by: duncanlegge

Original Ticket: "geneontology/ontology-requests/2966":https://sourceforge.net/p/geneontology/ontology-requests/2966

[gocentral]

Logged In: YES user_id=451873

Added new terms:

regulation of DNA damage response, signal transduction by p53 class mediator ; GO:0043516 positive regulation of DNA damage response, signal transduction by p53 class mediator ; GO:0043517 negative regulation of DNA damage response, signal transduction by p53 class mediator ; GO:0043518

and added your preferred strings (positive regulation of p53 induced by DNA damage response etx.) as exact synonyms

Original comment by: jl242

[gocentral]

• assigned_to: nobody --> jl242
• status: open --> closed-accepted

Original comment by: jl242