incorrect definition GO:0042351 de novo GDP-L-fucose biosyn

[gocentral]

The text of the definition of term GO:0042351 'de novo' GDP-L-fucose biosynthesis [Biological_process] may be incorrect.

Short version of request: Please replace "EC 1.1.1.281" with "EC 1.1.1.271" in the definition of this GO term.

Specfically, the last phrase of the definition currently states:

requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-4-dehydro-D-rhamnose reductase (EC:1.1.1.187).

Citing EC 1.1.1.187 rather than EC 1.1.1.271 (which I believe is the correct enzyme in the de novo pathway) is inconsistent with both the literature (c.f. Mattila 2000 PMID: 11030750) and the pathway for GDP-L-Fucose given on the IUBMB website.

http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/fucosyl.html

Note that in the IUBMB diagram, EC 1.1.1.281 and EC 4.2.1.47 both produce the same product (GDP-4-dehydro-D-rhamnose) which is the substrate for the next enzyme in the pathway, namely EC 1.1.1.271.

Thanks,

Eric L. Cabot

Reported by: ecabot

Original Ticket: "geneontology/ontology-requests/3019":https://sourceforge.net/p/geneontology/ontology-requests/3019

[gocentral]

• status: open --> closed

Original comment by: mah11

[gocentral]

Logged In: YES user_id=436423

definition corrected; thanks for the information

Original comment by: mah11

[gocentral]

• milestone: --> TermGenie
• assigned_to: nobody --> gomidori
• status: closed --> closed-fixed

Original comment by: mah11