Schwann cell proliferation

[gocentral]

Hi,

I would suggest some terms: Schwann cell proliferation; Schwann cell proliferation during axon regeneration;

[i] cell proliferation; GO:0008283 ---[i[ Schwann cell proliferation GO: new ------[i[ Schwann cell proliferation during axon regeneration; GO:new

Definition Schwann cell proliferation: The multiplication or reproduction of Schwann cells, resulting in the rapid expansion of the Schwann population. Schwann cells are a type of glia cell in the peripheral nervous system. (ISBN 0878932585).

Definition Schwann cell proliferation during axon regeneration: The multiplication or reproduction of Schwann cells, resulting in the rapid expansion of the Schwann population. Schwann cells are a type of glia cell in the peripheral nervous system. Their proliferation is critical for directing axon regeneration: when an axon is severed. the Schwann cells divide to form a pathway along which the axon can regrow from the proximal stump (ISBN 0878932585).

Thank you! Erika

Reported by: arike

Original Ticket: "geneontology/ontology-requests/3142":https://sourceforge.net/p/geneontology/ontology-requests/3142

[gocentral]

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Perhaps 'Schwann cell proliferation should also have "gliogenesis' (GO:0042063) as a parent?

Also, would 'tissue regeneration' (GO:0042246) or 'neurite regeneration' (GO:003102) be a proper parent for 'Schwann cell proliferation during axon regeneration'?? The relationship between the proposed Schwann cell terms and my proposed parent terms isn't entirely clear cut.

-Doug

Original comment by: doughowe

[gocentral]

Logged In: YES user_id=1285648

Hi Doug,

I think that we could add 'Schwann cell proliferation during axon regeneration' as a child of "axon regeneration' (GO:0031103) or 'regulation of axon extension during regeneration' (GO:0048690). I think that these terms could be proper parent.

About gliogenesis as parent of 'Schwann cell proliferation'. I think that we can insert the term 'Schwann cell proliferation' as a child of 'glia cell migration' GO:0008347, its definition is 'The orderly movement of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system'.

Coul be a probable solution? Thank you Erika

Original comment by: arike

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Hi, Erika, I don't think we should relate a 'proliferation' and a 'migration' term directly. These seem like relatively unrelated processes to me.

I think it might be OK to add 'Schwann cell proliferaton during axon regeneration' as a part_of 'axon regeneration' though.

-Doug

Original comment by: doughowe

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Hi Dough,

the probable solution could be:

[i] cell proliferation; GO:0008283 ---[i] Schwann cell proliferation GO: new; ------[i] Schwann cell proliferation during axon regeneration; GO:new;

[i] axon regeneration; GO:0031103; ---[p] Schwann cell proliferation during axon regeneration; GO:new;

[p] gliogenesis; GO:0042063; ---[p] glial cell proliferation; GO:new; ------[i] Schwann cell proliferation; GO: new;

What do you think? Erika

Original comment by: arike

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This is close. I've expanded the concept a bit... How about this:

cell proliferation (GO:0008283) ...[i]glial cell proliferation (GO:New) ......[i]Schwann cell proliferation (GO:New) .........[i]Schwann cell proliferation during axon regeneration (GO:New)

axon regeneration (GO:0031103) ...[i]axon regeneration in the peripheral nervous system (GO:New) ......[p]Schwann cell proliferation during axon regeneration (GO:New)

gliogenesis (GO:0042063) ...[p]glial cell proliferation (GO:New)

Here are some defs as well:

Schwann cell proliferation: The expansion of a population of Schwann cells by cell division. Schwann cells are a type of glial cell in the peripheral nervous system.

Schwann cell proliferation during axon regeneration: The expansion of a population of Schwann cells by cell division in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system.

glial cell proliferation: The expansion of a population of glial cells by cell division. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.

axon regeneration in the peripheral nervous system: The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury.

-Doug .

Original comment by: doughowe

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Hi, This last suggestion could be ok! I like it! So, can we add the terms now?

Erika

Original comment by: arike

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I agree these are ready to add...

-Doug

Original comment by: doughowe

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HI, I have added new terms

[Term] id: GO:0014009 name: glial cell proliferation namespace: biological_process def: "The multiplication or reproduction of glial cells by cell division\, resulting in the rapid expansion of their population. Glial cells exist throughout the nervous system\, and in clude Schwann cells\, astrocytes\, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585] exact_synonym: "glia proliferation" [] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0042063 ! gliogenesis

[Term] id: GO:0014010 name: Schwann cell proliferation namespace: biological_process def: "The multiplication or reproduction of Schwann cells\, resulting in the rapid expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system ." [GOC:ef, ISBN:0878932585] is_a: GO:0014009 ! glial cell proliferation

[Term] id: GO:0014011 name: Schwann cell proliferation during axon regeneration namespace: biological_process def: "The multiplication or reproduction of Schwann cells by cell division\, resulting in the rapid expansion of their population in response to an axonal lesion. The newly generated Sc hwann cells support subsequent axon regeneration in the peripheral nervous system." [GOC:ef, ISBN:0878932585] is_a: GO:0014010 ! Schwann cell proliferation relationship: part_of GO:0014012 ! axon regeneration in the peripheral nervous system

[Term] id: GO:0014012 name: axon regeneration in the peripheral nervous system namespace: biological_process def: "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury." [GOC:ef] is_a: GO:0031103 ! axon regeneration

Erika

Original comment by: arike

[gocentral]

• milestone: --> Plant Ontology
• assigned_to: nobody --> jenclark
• status: open --> closed-accepted

Original comment by: jenclark

[gocentral]

• assigned_to: Jennifer Deegan --> nobody
• Group: Plant Ontology --> None

Original comment by: cooperl09