gocentral
commented
18 years ago Logged In: YES user_id=835115
Hi Erika, These look good to me. I would use Type 1 synapse and Type 2 synapse as synonyms for your new terms. The content of the defs is fine, but the wording could be massaged a bit. I might suggest this:
Def asymmetric synapse: a type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density.
Def symmetric synapse: A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density.
Keep up the good work!!
-Doug
Original comment by: doughowe
Dear all,
I am annotating metabotropic glutamate 3 receptor (Q14832, Q9QYS2 and P31422) and I would ask for new terms: asymmetric synapse symmetric synapse
DAG structure: synapse, GO:0045202 ---[i] asymmetric synapse; GO:new; ---[i] symmetric synapse; GO:new;
Def asymmetric synapse: a type of synapse occurring between an axon and a dendritic spineand dendritic shafts. This kind of synapse is most abundant in the central nervous system. This type od synapse involves axons that contain predominantly round or spherical vesicles and form synapses that are distinguished by a thickened, postsynaptic density.
Def symmetric synapse: a type of synapse occurring primarily on dendrite shafts and neuronal cell bodies.This type od synapse involves axons that contain clusters of vesicles that are predominantly flattened or elongate in their appearance and it does not contain a prominent postsynaptic density.
Gray classified two types of synapses within the brain: -Type 1 -Type 2 These two categories were further distinguished by their locations: Type 1 synapses were found on dendritic spines and dendrite shafts, whereas Type 2 synapses occurred primarily on dendrite shafts and neuronal cell bodies. Virtually synonymous with Gray's nomenclature are the terms described by Colonnier: -Asymmetric Synapse -Symmetric Synapse
Asymmetric synapses include axons that contain predominantly round or spherical vesicles and form synapses that are distinguished by a thickened, postsynaptic density. In contrast, symmetric synapses involve axons that contain clusters of vesicles that are predominantly flattened or elongate in their appearance and this synapse does not contain a prominent postsynaptic density.
The sterotypical and most abundant synapse in the central nervous system is the asymmetric synapse occurring between an axon and a dendritic spine. Other synaptic relationships exist and involve different parts of the neuron.
Thanks Erika
Reported by: arike
Original Ticket: "geneontology/ontology-requests/3336":https://sourceforge.net/p/geneontology/ontology-requests/3336