ntr: sorbose reductase

[gocentral]

Hi,

I'd like to request an MF term for an enzyme that just recently got an EC number. The following info is from the IUBMB website

http://www.chem.qmul.ac.uk/iubmb/enzyme/newEC1.html\#111289

EC 1.1.1.289

Common name: sorbose reductase

Reaction: D-glucitol + NADP+ = L-sorbose + NADPH + H+

Systematic name: D-glucitol:NADP+ oxidoreductase

Comments: The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.

References:

1. Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E. Candida albicans SOU1 encodes a sorbose reductase required for L- sorbose utilization. Yeast 22 (2005) 957-969. [PMID: 16134116]

2. Sugisawa, T., Hoshino, T. and Fujiwara, A. Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1. Agric. Biol. Chem. 55 (1991) 2043-2049.

3. Shinjoh, M., Tazoe, M. and Hoshino, T. NADPH-dependent L- sorbose reductase is responsible for L-sorbose assimilation in Luconobacter suboxydans IFO 3291. J. Bacteriol. 184 (2002) 861-863. [PMID: 11790761]

---

I think the new term should be a child of: EC:1.1.1 > GO:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ; GO:0016616

A suggested definition would be: Catalysis of the reaction: L-sorbose + NADPH + H+ = D-glucitol + NADP+. The reaction may occur, to a minor extent, in the reverse direction.

Thanks, Maria

Reported by: mariacostanzo

Original Ticket: "geneontology/ontology-requests/3420":https://sourceforge.net/p/geneontology/ontology-requests/3420

[gocentral]

Logged In: YES user_id=436423

added sorbose reductase activity GO:0032115

Original comment by: mah11

[gocentral]

• assigned_to: nobody --> gomidori
• status: open --> closed-accepted

Original comment by: mah11