update def: transcription factor TFIIIC complex

[gocentral]

transcription factor TFIIIC complex appars to have cellular roles unrelated to transcription from pol III promoter.It might be useful to extend the def

A heterotrimeric transcription factor for eukaryotic RNA polymerase III promoters. It has also shown to function as a boundary element to partition genome content into distinct domains outside pol III promoter regions.

PMID: 16751097

Reported by: ValWood

Original Ticket: "geneontology/ontology-requests/3487":https://sourceforge.net/p/geneontology/ontology-requests/3487

[gocentral]

Logged In: YES user_id=473890

Hi,

I just went to a transcription meeting. Someone did talk about all Pol III transcription units as basically acting as boundary elements. I'm not sure they said anything about TFIIIC binding and having this function separated from Pol III transcription units. I'll check my notes and comment further.

-Karen

Original comment by: krchristie

[gocentral]

Logged In: YES user_id=516865

This is a quite big pombe paper (Cell). It was from the groups of Shiv Grwel (works on chromatin mediated silencing) and Rich Maraia (works on TFIIIC, in fact isn't he a cerevisiae person, you probably know him)

I haven't got it here but I'm pretty certain this occurred outside of polIII transcription units (I.e TFIIIC complex (without RNA pol III ) was detected in the regions of the promoters of Pol II transcribed genes).

However, it probably isn't known at present whether this is a general phenomona

Original comment by: ValWood

[gocentral]

• assigned_to: nobody --> kchris

Original comment by: mah11

[gocentral]

Any outcome for this? Did I also see a more frequent item about TFIII definitiion?

Val

Original comment by: ValWood

[gocentral]

I means more recent...

Original comment by: ValWood

[gocentral]

there was the TFIIIE one ... https://sourceforge.net/tracker/?func=detail&aid=2512097&group\_id=36855&atid=440764

Original comment by: mah11

[gocentral]

Please see: http://wiki.geneontology.org/index.php/Transcription

Original comment by: rebeccafoulger

[gocentral]

• labels: --> transcription
• status: open --> closed-out-of-date

Original comment by: rebeccafoulger

[gocentral]

• status: closed-out-of-date --> pending-out-of-date

Original comment by: rebeccafoulger

[gocentral]

The transcription overhaul did not address component terms, so this item was not handled as part of it.

Original comment by: krchristie

[gocentral]

• status: pending-out-of-date --> open-out-of-date

Original comment by: krchristie

[gocentral]

• status: open-out-of-date --> open-later

Original comment by: krchristie

[gocentral]

• assigned_to: kchris --> paolaroncaglia
• status: open-later --> open

Original comment by: paolaroncaglia

[gocentral]

Hi Val, this is done:

Expanded definition of GO:0000127 transcription factor TFIIIC complex.

Thanks, Paola

Original comment by: paolaroncaglia

[gocentral]

• status: open --> closed-accepted

Original comment by: paolaroncaglia

[gocentral]

• milestone: --> PomBase

Original comment by: mah11