mp: histone demethylase activity (H3-K36 specific)

[gocentral]

Is this occuring via an oxidation reaction, something i was reading implies it is, so should it have a parent to reflect this?

Uniprot entries containing this activity map to

"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"

so if this isn't correct this mapping will need to be removed.

Reported by: ValWood

Original Ticket: "geneontology/ontology-requests/3521":https://sourceforge.net/p/geneontology/ontology-requests/3521

[gocentral]

Logged In: YES user_id=473890

Hi Val,

This term is currently in a very general location because when I requested it, I didn't know enough about it to suggest something more specific, see this SF item:

[ 1410179 ] NTR: histone H3-K36 demethylase

There is a pending entry in the EC classification that may help place this term appropriately: http://www.chem.qmul.ac.uk/iubmb/enzyme/newenz.html\#1141127

-Karen

Original comment by: krchristie

[gocentral]

Logged In: YES user_id=516865

O.K. that looks consistent.

cheers

val

Original comment by: ValWood

[gocentral]

Logged In: YES user_id=473890

Hi Val,

Sorry, could you clarify, what looks consistent?

Also, let me check, when I put in the string you used: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" into OBO-Edit, I get only one GOid:

GO:0016702

Are you suggesting that this term "histone demethylase activity (H3-K36 specific)" should get parentage under that term?

Just trying to clarify exactly what needs to be done so that someone, possibly even me, can do this.

thanks,

-Karen

Original comment by: krchristie

[gocentral]

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it looks like the proposal is to place under 1.14.11 which is GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

this is a child term of the one which I am picking up from a mapping so we can probably go ahead and add this.

Original comment by: ValWood

[gocentral]

Logged In: YES user_id=473890

OK, moved

GO:0051864 histone demethylase activity (H3-K36 specific)

to be a child of

GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

-Karen

Original comment by: krchristie

[gocentral]

• labels: --> Other term-related request
• assigned_to: nobody --> kchris
• status: open --> closed-fixed

Original comment by: krchristie

[gocentral]

• milestone: --> PomBase

Original comment by: mah11