Closed gocentral closed 9 years ago
myelination obo snippet for illustration only
Original comment by: doughowe
Original comment by: mah11
Logged In: YES user_id=436423
Thanks for the obo file - very helpful!
Looks good ... I've corrected a couple of typos, and left out one or two relationships that appeared in the obo file but would've been redundant. Otherwise, all done as suggested.
new terms: ensheathment of non-myelinated axons GO:0032285 myelin maintenance in the central nervous system GO:0032286 myelin maintenance in the peripheral nervous system GO:0032287 myelin formation GO:0032288 myelin formation in the central nervous system GO:0032289 myelin formation in the peripheral nervous system GO:0032290 ensheathment of axons in the central nervous system GO:0032291 ensheathment of non-myelinated axons in the central nervous system GO: 0032293 ensheathment of non-myelinated axons in the peripheral nervous system GO: 0032294 ensheathment of neuronal cell bodies GO:0032295
m :)
Original comment by: mah11
Original comment by: mah11
Logged In: YES user_id=835115
Midori...This is closed...almost.
I think you added 'myelin formation' as an is_a child of 'myelination'...it should be a part_of.
I've set up myelination to have two parts...formation and maintenance.
-Doug
Original comment by: doughowe
Logged In: YES user_id=436423
oops, you're right! I was even thinking 'part_of' but clicked 'is_a' anyway. Now fixed. :)
m
Original comment by: mah11
Logged In: YES user_id=835115
And one more odd item..
It looks like 'glial cell development' is both is_a and part_of 'cell development'. Should only be is_a.
-Doug
Original comment by: doughowe
Logged In: YES user_id=436423
fixed that too ... wonder what was going on in my head that day!
m
Original comment by: mah11
Original comment by: cooperl09
The terms related to myelination need some help...so here is my proposal. The steps to take are outlined below. The attached file is a snipped of an obo file just to illustrate the desired structure.
-Doug
I. Rename and then merge these terms Rename 'cellular nerve ensheathment' (GO:0042553) to 'cellular axon ensheathment" Rename 'nerve ensheathment' (GO:0008366) to "axon ensheathment" Merge 'cellular axon ensheathment' (GO:0042553) into 'axon ensheathment' GO:0008366 Finally, 'axon ensheathment' (GO:0008366) should not be a child of neuron maturation....instead it should be is_a GO:0007272
II Rename these terms Rename 'ionic insulation of neurons by glial cells' (GO:0007272) to 'ensheathment of neurons'...no obsoletion should be necessary Rename 'central nervous system myelination' (GO:0022010) to 'myelination in the central nervous system Rename 'peripheral nervous system myelination' (GO:0022011) to 'myelination in the peripheral nervous system
III. Add new relationships 'glial cell development' (GO:0021782) is_a 'cell development (GO:0048468) 'Schwann cell development' (GO:0014044) is_a 'glial cell development' (GO:0021782) 'paranodal junction assembly' (GO:0030913) part_of 'myelin formation (GO:new)
IV. Add the following new terms
name: ensheathment of non-myelinated axons def: The process by which a non-myelinating glial cell membrane closes around an axon. is_a: GO:0008366 ! axon ensheathment
name: myelin maintenance in the central nervous system def: The process by which the structure and material content of mature central nervous system myelin is kept in a functional state.
is_a: GO:0043217 ! myelin maintenance relationship: part_of GO:0022010 ! myelination in the central nervous system
name: myelin maintenance in the peripheral nervous system def: The process by which the structure and material content of mature peripheral nervous system myelin is kept in a functional state.
is_a: GO:0043217 ! myelin maintenance relationship: part_of GO:0022011 ! myelination in the peripheral nervous system
name: myelin formation def: The process by which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. relationship: part_of GO:0042552 ! myelination
name: myelin formation in the central nervous system def: The process by which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system. is_a: GO:new ! myelin formation relationship: part_of GO:0022010 ! myelination in the central nervous system (GO:0022010)
name: myelin formation in the peripheral nervous system def: The process by which the wraps of cell membrane that constitute myelin are laid down around an axon by a Schwann cell in the peripheral nervous system. is_a: GO:new ! myelin formation relationship: part_of GO:0022011 ! myelination in the peripheral nervous system (GO:0022011)
name: ensheathment of non-myelinated axons in the central nervous system def:The process by which a non-myelinating glial cell membrane encircles an axon in the central nervous system. is_a: GO:new ! ensheathment of non-myelinated axons is_a: GO:new ! ensheathment of axons in the central nervous system
name: ensheathment of axons in the central nervous system def: The process by which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial
interaction. is_a: GO:0008366 ! axon ensheathment
name: ensheathment of neuronal cell bodies def: The process by which satellite glial cells isolate neuronal cell bodies. is_a: GO:0007272 ! ensheathment of neurons
name: ensheathment of non-myelinated axons in the peripheral nervous system def: The process by which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. interaction. A single non-myelinating
Schwann cell will typically associate with multiple axons. is_a: GO:new ! ensheathment of non-myelinated axons is_a: GO:new ! ensheathment of axons in the peripheral nervous system
name: ensheathment of axons in the peripheral nervous system def: The process by which a Schwann cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating
neuron-glial interaction. is_a: GO:0008366 ! axon ensheathment
Reported by: doughowe
Original Ticket: "geneontology/ontology-requests/3540":https://sourceforge.net/p/geneontology/ontology-requests/3540