ntr repeat stability

[gocentral]

I'm annotating some of the ref genome papers for msa2/3/6. It seems that Msh2,6, and Pms1 have an importent role int eh maintenence of tract length variation in nulceotide repeats.

~So could we have a term (child of DNA metabolism?)

DNA repeat stability.

def the maintenence of tract length variation in nulceotide repeats

Reported by: ValWood

Original Ticket: "geneontology/ontology-requests/3606":https://sourceforge.net/p/geneontology/ontology-requests/3606

[gocentral]

Logged In: YES user_id=436423

hmm. DNA repeat stability sounds like a trait rather than a process. How about 'regulation of DNA repeat stability' or 'regulation of DNA repeat copy number' or some such?

m

Original comment by: mah11

[gocentral]

Logged In: YES user_id=516865

OK, I knew it seemd like an odd term but I couldn't work out why.

Its probably good to have a process because it is probably analogous to the processes which allow repeat expansions in telomerically encoded cell surface proteins (I tink there was a S. cerevisiae paper on this recently).

There is a term maintenance of DNA repeat elements def Any process involved in sustaining the fidelity and copy number of DNA repeat elements.

which I considered but rejected becasue the def refers to large tandem repeats. However I think it xould be a child of htis term, if the def was broadened?

(there appears to be a child specific for rDNA repeats)

the term could be maintence of microsatellite repeat copy number? or similar?

Original comment by: ValWood

[gocentral]

Logged In: YES user_id=436423

Why can't you use the term 'maintenance of DNA repeat elements' (GO: 0043570)? The bit you copie is the entire def; it doesn't say anything at all about what kind or length of repeat. (In fact the child term 'maintenance of CRISPR DNA repeat elements' GO:0043571 sounds like it's not about large tandem repeats.)

m

Original comment by: mah11

[gocentral]

Logged In: YES user_id=516865

yes you are right, i don't know why i didn't like this term, its pectly OK, i will use it, so close this!

Original comment by: ValWood

[gocentral]

Logged In: YES user_id=436423

OK :)

Original comment by: mah11

[gocentral]

• status: open --> closed-works-for-me

Original comment by: mah11

[gocentral]

• milestone: --> PomBase

Original comment by: mah11