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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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NTR microtubule stabilization #3628

Closed gocentral closed 9 years ago

gocentral commented 17 years ago

we have axonemal microtubule stabilization i wonder if this can have a parent microtubule stabilization

Reported by: ValWood

Original Ticket: "geneontology/ontology-requests/3643":https://sourceforge.net/p/geneontology/ontology-requests/3643

gocentral commented 17 years ago

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"Microtubule stabilization" is an exact synonym of GO:0007026, negative regulation of microtubule depolymerization.

m

Original comment by: mah11

gocentral commented 17 years ago

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Ah yes. i think stabilization may be broader than regulation of depolymerization. it may also cover stabilization of the open/closed configuration.

If not, I think 'microtubule stabilization' is a more logical primary name...are David or harold experts on this?

Original comment by: ValWood

gocentral commented 17 years ago

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do you have a ref for 'open/closed configuration'? I don't know what that means ...

Original comment by: mah11

gocentral commented 17 years ago

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No it was from a talk i went to last week. It seems that microtubule polymerization doesn't happen anything like it looks in my text books!

I could only find this review though, and these conformatiosn might be an artefact of the cryo-electron microscopy.

you can close this, I'll reopen if I have more info as I'm not annotating these now...

http://www.biophysj.org/cgi/content/abstract/80/3/1151http://cryoem.berkeley.edu/papers/cyto\_review/index.html

Original comment by: ValWood

gocentral commented 17 years ago

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The Biophys J paper is talking about the conformation of a motor protein, not the microtubules.

The cryo-em thing is pretty cool, but what we have in GO doesn't actually specify anything inconsistent (trying to avoid saying GO is vague!). So I think we're ok.

m

Original comment by: mah11

gocentral commented 17 years ago

Original comment by: mah11

gocentral commented 17 years ago

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more info

PMID: 17190604

"We provide structural data showing that the alignment of Mal3p molecules coincides with the microtubule lattice seam as well as data suggesting that Mal3p not only binds but also stabilizes this seam. Accordingly, Mal3p stabilizes microtubules through a specific interaction with what is potentially the weakest part of the microtubule in a way not previously demonstrated. Our findings further suggest that microtubules exhibit two distinct reaction platforms on their surface that can independently interact with target structures such as microtubule-associated proteins, motors, kinetochores, or membranes"

cool stuff

I think it requires a vew term for microtubule stabilization that isn' under depolymerization?

I haven't read it properly yet...

Original comment by: ValWood

gocentral commented 17 years ago

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Upon reading PMID: 17190604, I've definitely got the impression that MT stabilization by Mal3p does fit 'negative regulation of depolymerization'; they've just done clever things to find a nifty mechanism by which it works.

m

Original comment by: mah11

gocentral commented 13 years ago

Original comment by: mah11