sense-PTGS

[gocentral]

Hi,

I came across a term 'sense-PTGS (posttranscriptional gene silencing' when annotating an Arabidopsis gene SE [PMID 16889646, see figure 4]. Could anyone familiar with gene silencing add this term/synonym please?

Thanks!

Donghui

Reported by: donghui

Original Ticket: "geneontology/ontology-requests/4021":https://sourceforge.net/p/geneontology/ontology-requests/4021

[gocentral]

Logged In: YES user_id=436423 Originator: NO

emailed Nick Stover and Val Wood to look at this

Original comment by: mah11

[gocentral]

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Never come across it but.....

Post-transcriptional gene silencing (PTGS) was unveiled by analyses of transgenic plants in which the transgene mRNA level was reduced under constant transcription of the transgene (Napoli et al. 1990; van der Krol et al. 1990). When a cDNA originated from plant mRNAs is introduced into the same plant, PTGS is established by coordinated silencing of both the transgene and endogenous homologous gene (Hamada and Kodama 2006). The RNAi pathway seems to account for the molecular basis of PTGS, because siRNAs against the transgene exist in the plants showing PTGS. In these plants, sense transcripts from the transgene locus are regarded as “aberrant” RNAs and then converted into dsRNAs by RdRP. Therefore, this type of PTGS is often called sense-PTGS (S-PTGS).

Journal Plant Molecular Biology Publisher Springer Netherlands ISSN 0167-4412 (Print) 1573-5028 (Online) Subject Biomedical and Life Sciences Issue Volume 63, Number 6 / April, 2007

It seems to be canonical RNA interference ?

perhaps it should be an exact synonym of this?

Original comment by: ValWood

[gocentral]

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added synonym to 'posttranscriptional gene silencing by RNA' GO:0035194

Original comment by: mah11

[gocentral]

• milestone: --> TAIR
• assigned_to: nobody --> gomidori
• status: open --> closed-accepted

Original comment by: mah11