NTR: Sphingomyelin synthase activity

[gocentral]

Hi,

Based on PMID:14976195 and PMID:14685263 could we have molecular function term for EC 2.7.8.27?

I suggest sphingomyelin synthase activity as this is the official enzyme name, see http://www.expasy.org/cgi-bin/nicezyme.pl?2.7.8.27

We already have GO:0047493 ceramide cholinephosphotransferase activity for EC 2.7.8.3 (http://www.expasy.org/enzyme/2.7.8.3).

Thanks, Varsha

Reported by: vkhodiyar

Original Ticket: "geneontology/ontology-requests/4127":https://sourceforge.net/p/geneontology/ontology-requests/4127

[gocentral]

Logged In: YES user_id=1266900 Originator: YES

Additional info from http://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=2.7.8.27&status=OK

The reaction can occur in both directions [PMID: 14685263]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [PMID: 16905542]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [PMID: 16905542]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [PMID: 7093220].

Thanks, Varsha

Original comment by: vkhodiyar

[gocentral]

Logged In: YES user_id=436423 Originator: NO

added GO:0033188

Original comment by: mah11

[gocentral]

• milestone: --> PAINT
• assigned_to: nobody --> gomidori
• status: open --> closed-accepted

Original comment by: mah11