transcription factor TFTC complex

[gocentral]

Hi,

New term request for 'transcription factor TFTC complex'.

transcription factor complex (GO:0005667) --[i] transcription factor TFTC complex (GO:new)

DNA-directed RNA polymerase II, holoenzyme (GO:0016591) --[i] transcription factor TFTC complex (GO:new)

Proposed definition:

A complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins. This complex is able to nucleate RNA polymerase II transcription and can mediate transcriptional activation.

References: PMID: 9603525 PMID:10373431

Cheers, Emily

Reported by: edimmer

Original Ticket: "geneontology/ontology-requests/4220":https://sourceforge.net/p/geneontology/ontology-requests/4220

[gocentral]

Logged In: YES user_id=473890 Originator: NO

Hi,

Based on the second paper cited, I'd just suggest a couple modifications to the definition, like this:

A complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.

-Karen

Original comment by: krchristie

[gocentral]

Logged In: YES user_id=436423 Originator: NO

Thanks!

added GO:0033276

Original comment by: mah11

[gocentral]

• milestone: --> TermGenie
• assigned_to: nobody --> gomidori
• status: open --> closed-accepted

Original comment by: mah11