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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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DNA translocase activity #4896

Closed gocentral closed 9 years ago

gocentral commented 16 years ago

GO:0015616 DNA translocase activity

Definition Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive movement along a single- or double-stranded DNA molecule.

I'm confued by this comment becasue I didn't think this terms referred to things which transferred DNA across membranes?

Comment Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane.

Reported by: ValWood

Original Ticket: "geneontology/ontology-requests/4911":https://sourceforge.net/p/geneontology/ontology-requests/4911

gocentral commented 16 years ago

Logged In: YES user_id=436423 Originator: NO

Yes, some translocases drive movement across membranes, mainly in bacteria. I read all about it when I did the definition and comment. See PMID 18160039 for a nice example.

Original comment by: mah11

gocentral commented 16 years ago

Original comment by: mah11

gocentral commented 16 years ago

Logged In: YES user_id=516865 Originator: YES

Hmm. I think then that this type of DNA translocase should be a child of 'DNA transmembrane transporter activity'

The definition seems like it is describing something else here"movement along a single- or double-stranded DNA molecule." so does DNA translocase have 2 different meanings (I'm sure we did this in transporter working group, so the notes may be on the WIKI)

Whichever, the type of DNA translocase that refers to transporting needs a 'transporter activity' parent

Original comment by: ValWood

gocentral commented 16 years ago

Logged In: YES user_id=436423 Originator: NO

Thing is, the activity is the same in both cases; if the translocase is anchored near a membrane the DNA can be moved across the membrane, but it doesn't have a different activity from the translocases that move themselves along DNA or that move DNA but not across a membrane. It's an excellent example of the distinction between function and process.

m

Original comment by: mah11

gocentral commented 16 years ago

Logged In: YES user_id=516865 Originator: YES

I see, ignore then!

Original comment by: ValWood

gocentral commented 13 years ago

Original comment by: mah11