small typos and query/SAGA

[gocentral]

A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.

should say possesses histone acetyltransferase activity and and is involved in regulation...

The final sentance is a little confusing, because the presence of a nearly identical complex (SLIK) implies that the subunit composition is very specific, and indeed the pombe analogous complex has identical composition (all 19 subunits are orthologous and conserved)

However, this has annotations from fly and dicty where the subunit composition is different (at present some subunits appear to be fungal specific)

So I guess my question is, should this represent a grouping term for various complexes, or a specific term for the fungally conserved SAGA?

Reported by: ValWood

Original Ticket: "geneontology/ontology-requests/4981":https://sourceforge.net/p/geneontology/ontology-requests/4981

[gocentral]

Logged In: YES user_id=436423 Originator: NO

Typos fixed.

It looks like we may have originally meant for GO:0000124 to be used for any SAGA-family HAT complex, but that was a long time ago and we've drifted away from the early "plan". For example, STAGA (GO:0030914) is kinda sorta a human SAGA, and PCAF (GO:0000125) is also pretty similar.

I can either change "other species" to "other fungal species", or delete the second clause of the last sentence entirely. Any preference?

m

Original comment by: mah11

[gocentral]

• labels: --> Other term-related request
• milestone: --> 224410
• assigned_to: nobody --> gomidori

Original comment by: mah11

[gocentral]

Logged In: YES user_id=436423 Originator: NO

used 'fungal' to get this done 'n' dusted; reopen if the sentence should go entirely

Original comment by: mah11

[gocentral]

• status: open --> closed-fixed

Original comment by: mah11

[gocentral]

Logged In: YES user_id=516865 Originator: YES

so would this term become specific for fungal SAGA? that may cause problems as it has non-fungal annotation (human, drosopila, dicty)

I don't know if SLIK (the SAGA- like complex) occurs in pombe (or if this is just a SAGA under differnet conditions where not all subunits were isolated, SLIK appears to be SAGA with 1.5? subunits missing).pombe SAGA has the same 19 subunits as S. cerevisiae SAGA....

may need to ask Karen to look at this one. I'm in no hurry for this. at the moment. I know the pombe SAGA paper is pending but it isn't published yet.....

Original comment by: ValWood

[gocentral]

• milestone: 224410 --> PomBase

Original comment by: mah11