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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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change definition of GO:0034075 #5279

Closed gocentral closed 9 years ago

gocentral commented 16 years ago

The current definition for this term defines the product of the reaction based on a review article as:

arabidiol ((3S,13R,14R)-malabarica-17E,21-dien-3beta,14-diol). [source: GOC:cb, PMID:18033581]

But, in a report on defining the structure of arabidiol, they report the structure as: we conclude that arabidiol (2) is (13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol.

Therefore, I propose changing the definition of this term to be:

Catalysis of the reaction: oxidosqualene = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol). [source: GOC:cb, PMID:17474751]

Reported by: kadreher

Original Ticket: "geneontology/ontology-requests/5296":https://sourceforge.net/p/geneontology/ontology-requests/5296

gocentral commented 16 years ago

Logged In: YES user_id=1958561 Originator: YES

Ooops. I forgot to include that in the PMID 16774269, they suggest that water is also involved in the reaction: "Arabidiol synthase is the first OSC yielding a single product with a hydroxyl group originating from a water molecule."

So, please see the new proposed definition below:

Catalysis of the reaction: oxidosqualene + H2O= arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol). [source: GOC:cb, PMID:17474751, 16774269]

Original comment by: kadreher

gocentral commented 16 years ago

Logged In: YES user_id=1958561 Originator: YES

Ooops. I forgot to include that in the PMID 16774269, they suggest that water is also involved in the reaction: "Arabidiol synthase is the first OSC yielding a single product with a hydroxyl group originating from a water molecule."

So, please see the new proposed definition below:

Catalysis of the reaction: oxidosqualene + H2O= arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol). [source: GOC:cb, PMID:17474751, 16774269]

Original comment by: kadreher

gocentral commented 16 years ago

Logged In: YES user_id=1473024 Originator: NO

Hello,

I'm happy with this change given the new evidence.

best wishes, Colin.

Original comment by: batchelorc

gocentral commented 16 years ago

Logged In: YES user_id=436423 Originator: NO

Definition updated; thanks both Kate and Colin! m

Original comment by: mah11

gocentral commented 16 years ago

Original comment by: mah11