NTR: various rRNA methyltransferase activities

[gocentral]

I just plowed through the known E. coli rRNA methyltransferases and discovered that there are no specific GO function terms for a number of them.

* rRNA (guanosine-2'-O-)-methyltransferase (RlmB)

• rRNA (pseudouridine-N3-)-methyltransferase (RlmH)
• rRNA (adenine-C2-)-methyltransferase (RlmN)
• rRNA (uridine-C5-)-methyltransferase (RlmD)
• rRNA (uridine-N3-)-methyltransferase (RsmE)
• rRNA (guanine-N7-)-methyltransferase (RsmG)

They all use S-adenosylmethionine as the methyl group donor, and I assume that they can all be treated in a way analogous to existing rRNA methyltransferase activities. The pseudouridine one may also need a new parent, rRNA (pseudouridine) methyltransferase activity.

There seems to be an additional rRNA modification for which no enzyme has been identified yet (m4C); I'm attaching a figure from the online EcoSal book (chapter 4.6.1) that shows all the modifications.

Thanks!

-Ingrid

Reported by: imk07

Original Ticket: "geneontology/ontology-requests/5469":https://sourceforge.net/p/geneontology/ontology-requests/5469

[gocentral]

Original comment by: imk07

[gocentral]

Thanks! I've added these terms:

rRNA (pseudouridine) methyltransferase activity GO:0070037 rRNA (pseudouridine-N3-)-methyltransferase activity GO:0070038 rRNA (guanosine-2'-O-)-methyltransferase activity GO:0070039 rRNA (adenine-C2-)-methyltransferase activity GO:0070040 rRNA (uridine-C5-)-methyltransferase activity GO:0070041 rRNA (uridine-N3-)-methyltransferase activity GO:0070042

We can add a term for m4C if the enzyme is found.

m

Original comment by: mah11

[gocentral]

• milestone: --> TermGenie
• status: open --> closed-accepted

Original comment by: mah11

[gocentral]

• assigned_to: nobody --> gomidori

Original comment by: mah11