regulation of response to tumor necrosis factor

[gocentral]

Hi

Today I am annotating ADIPOQ Q15848 with PMID:10604883 data.

Treatment with ADIPOQ before stimulation with TNF reduces the TNF enhanced adhesion of monocytes to aortic endothelial cells.

So I was wondering if the NTR: negative regulation of response to tumor necrosis factor could be created.

Thanks

Ruth

Reported by: RLovering

Original Ticket: "geneontology/ontology-requests/5472":https://sourceforge.net/p/geneontology/ontology-requests/5472

[gocentral]

sorry this would be as a child to GO:0034612 response to tumor necrosis factor

Original comment by: RLovering

[gocentral]

• assigned_to: nobody --> tairtb

Original comment by: mah11

[gocentral]

Do you think it might be better to use the (not yet existing) term 'negative regulation of tumor necrosis factor-mediated signaling pathway'?

The signaling pathway is the response to TNF. It's a more specific and descriptive term.

Original comment by: tberardini

[gocentral]

We may even want to merge 'response to TNF' and 'tumor necrosis factor-mediated signaling pathway' because we can't think of differences between these two. Can you?

Original comment by: tberardini

[gocentral]

Hi

I think it is necessary to get the 'response to' terms with more specific definitions so that people are clear about what can be associated with these terms (see response to SF items/reference genome). However having a quick browse of the response to ontologies I wonder if something more constructive could be sorted out.

Basically if you delete response to TNF then I guess you would need to delete loads of response to terms which are in a similar vein, response to insulin, hormone, cytokine, pheromone.

Interestingly response to hormone stimulus has the child terms GO:0009755 hormone-mediated signaling GO:0043434 response to peptide hormone stimulus GO:0009720 detection of hormone stimulus GO:0048545 response to steroid hormone stimulus etc and I wondered if actually the signaling pathway terms should be child terms of the response to hormone/cytokine etc stimulus?

Although if it is generally agreed to cut down many of the response to terms in this way (by incorporating them in signaling pathways) then I agree I personally think this is probably what is meant by response to ..... but at present there are wide variations in how to interpret the start/stop of the response to processes.

In the meantime, if you create negative regulation of tumor necrosis factor-mediated signaling pathway I would be happy to use it!

Thanks

Ruth

Original comment by: RLovering

[gocentral]

Added:

regulation of tumor-necrosis factor mediated signaling pathway ; GO:0010803 negative regulation of tumor-necrosis factor mediated signaling pathway ; GO:0010804

Original comment by: ukemi

[gocentral]

• status: open --> closed-fixed

Original comment by: ukemi