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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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Add lethargus as synonym for sleep #5544

Closed gocentral closed 9 years ago

gocentral commented 16 years ago

Hi--

I would like to add the term 'lethargus' as a related synonym for GO:0030431 sleep.

I'm annotating genes from the paper cited below that are required for inducing lethargus, which has now been characterized in C. elegans as a sleep-like state.

Thanks, --Kimberly

Title: Lethargus is a Caenorhabditis elegans sleep-like state . Authors: Raizen DM Zimmerman JE Maycock MH Ta UD You YJ Sundaram MV Pack AI Journal: Nature Year: 2008 Doc ID: WBPaper00031383 Accession (PMID): PMID18185515

Abstract:

There are fundamental similarities between sleep in mammals and quiescence in the arthropod Drosophila melanogaster , suggesting that sleep-like states are evolutionarily ancient . The nematode Caenorhabditis elegans also has a quiescent behavioural state during a period called lethargus , which occurs before each of the four moults . Like sleep , lethargus maintains a constant temporal relationship with the expression of the C elegans Period homologue LIN-42 ( ref . 5 ) . Here we show that quiescence associated with lethargus has the additional sleep-like properties of reversibility , reduced responsiveness and homeostasis . We identify the cGMP-dependent protein kinase ( PKG ) gene egl-4 as a regulator of sleep-like behaviour , and show that egl-4 functions in sensory neurons to promote the C elegans sleep-like state . Conserved effects on sleep-like behaviour of homologous genes in C elegans and Drosophila suggest a common genetic regulation of sleep-like states in arthropods and nematodes . Our results indicate that C elegans is a suitable model system for the study of sleep regulation . The association of this C elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to allow for developmental changes .

Reported by: vanaukenk

Original Ticket: "geneontology/ontology-requests/5562":https://sourceforge.net/p/geneontology/ontology-requests/5562

gocentral commented 16 years ago

synonym added

Original comment by: mah11

gocentral commented 16 years ago

Original comment by: mah11

gocentral commented 16 years ago

Thanks, Midori.

--K.

Original comment by: vanaukenk