Expansion of platelet activation

[gocentral]

In the course of annotation of Lyst, I have come across several mutations leading to reduced platelet aggregation (actually assayed). Currently, aggregation is mentioned as a part of the process of platelet activation as summarized below:

GO term: platelet activation GO id: GO:0030168 Definition: A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.

I might be of use to expand this entry to include separate subterms for shape, adhesion, aggregation, and release (I assume part_of). I am not an adequate expert to fill in precise defintions . Perhaps an expert can expand this.

Reported by: hdrabkin

Original Ticket: "geneontology/ontology-requests/5734":https://sourceforge.net/p/geneontology/ontology-requests/5734

[gocentral]

I don't know anything much about platelets either, but maybe someone at Reactome would know some helpfully inclined experts. Peter d'E is probably a good start -- he seems to do a lot of the Reactome mammalian system stuff and pays quite a bit of attention to GO these days. Good luck!

m

Original comment by: mah11

[gocentral]

I was thinking you might prevail upon Alex?

Original comment by: hdrabkin

[gocentral]

We now have 'platelet aggregation ; GO:0070527' as a part_of child of platelet activation.

So it looks like this has been done. If you need any more terms, please go ahead and open up a new SF item.

Thanks!

Original comment by: rebeccafoulger

[gocentral]

• status: open --> closed-out-of-date

Original comment by: rebeccafoulger