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Source ontology files for the Gene Ontology
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specific granule #601

Closed gocentral closed 9 years ago

gocentral commented 21 years ago

Could we have the following new term for the location of EC2.4.2.31? Reference: Eur. J. Biochem. 1992;204:305-311 ADP-ribosylation of actins by arginine-specific ADP-ribosyltransferase purified from chicken heterophils Terashima, M.; Mishima, K.; Yamada, K.; Wakutani, T.; Shimoyama, M.

%secretory granule ; GO:0030141 ; synonym:secretory vesicle %specific granule ; GO:00nnnnn ;

Definition: specific granules (= secondary granules) One of the two main classes of granules found in neutrophils: contain lactoferrin, lysozyme, Vitamin B12 binding protein and elastase. Are released more readily than the azurophil (primary) granules which have typical lysosmal contents. (Dictionary of Cell and Molecular Biology)

neutrophil (= neutrophil granulocyte; polymorphonuclear leucocyte; PMN or PMNL) Commonest (2500-7500/mm3 ) blood leucocyte; a short-lived phagocytic cell of the myeloid series, which is responsible for the primary cellular response to an acute inflammatory episode, and for general tissue homeostasis by removal of damaged material. Adheres to endothelium (margination) and then migrates into tissue, possibly responding to chemotactic signals. Contain specific and azurophil granules. Author: John Lackie (Dictionary of Cell and Molecular Biology)

Reported by: brendamg

Original Ticket: "geneontology/ontology-requests/601":https://sourceforge.net/p/geneontology/ontology-requests/601

gocentral commented 21 years ago

Logged In: YES user_id=451873

Added term 'specific granule ; GO:0042581' as child of 'secretory granule ; GO:0030141' with definition:

Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.

Original comment by: jl242

gocentral commented 21 years ago

Original comment by: jl242