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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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mast cell granule #605

Closed gocentral closed 9 years ago

gocentral commented 21 years ago

Could we have the following new term for the localization of the enzyme EC 3.4.21.59 (Tryptase)?

%secretory granule ; GO:0030141 ; synonym:secretory vesicle %mast cell granule ; GO:00nnnnn

http://cellpath.unm.edu/wilsonlab.htm The mast cell granule is best described as a modified lysosome, specialized for fusion with the plasma membrane, and with other lysosomal granules, after receptor activation. Although similar "secretory lysosomes" are found in other hematopoietic cells, little is known about the mechanisms by which these organelles receive their cargo.

In our references the mast cell granules are also described as a kind of "secretory granules".

Arch. Biochem. Biophys. 1985;239:436-443 Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions Kido, H.; Fukusen, N.; Katunuma, N.

Methods Enzymol. 1994;244:88-100 Tryptase: a mast cell serine protease Schwartz, L.B.; review

Reported by: brendamg

Original Ticket: "geneontology/ontology-requests/605":https://sourceforge.net/p/geneontology/ontology-requests/605

gocentral commented 21 years ago

Logged In: YES user_id=451873

Should be fine - I'll add as a type of lysosome, part of cytoplasm.

Original comment by: jl242

gocentral commented 21 years ago

Original comment by: jl242

gocentral commented 21 years ago

Logged In: YES user_id=451873

Added 'mast cell granule ; GO:0042629'.

Original comment by: jl242

gocentral commented 21 years ago

Original comment by: jl242