change definition GO:0004018 adenylosuccinate lyase activity

[gocentral]

Now, the definition is "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP", which is true, but the chicken and human enzymes (and perhaps orthologs generally - see http://www.expasy.org/enzyme/4.3.2.2) also catalyze a second reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate <=> fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

So, revised (broader) definition: "Catalysis of the reactions: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP, and (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide."

Or if that's too unwieldy and some sort of patch with synonyms is better, that works. As far as I can tell, the re-defined term still fits OK in its current place in the term hierarchy.

Thanks

Peter

Reported by: deustp01

Original Ticket: geneontology/ontology-requests/6099

[gocentral]

I've

- renamed GO:0004018 to 'N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity' (specificity matches def)

- added (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity GO:0070626

- done some synonym adjustments

I'm just a bit paranoid about whether all orthologs act on both substrates, and it's more in keeping with GO's emphasis on individual reactions (as opposed to grouping based on gene products).

m

Original comment by: mah11

[gocentral]

• assigned_to: nobody --> gomidori
• status: open --> closed-fixed

Original comment by: mah11