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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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pre-BCR complex #7401

Closed gocentral closed 9 years ago

gocentral commented 14 years ago

New term needed for pre B-cell receptor complex. Needed for CL cross-product definition and probably a good idea to include in the GO anyway:

id: GO:NewTer1 New term: pre-B cell receptor complex def: "An immunoglobulin-like complex that is present in the plasma membrane of pre-B cells and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. " [GOC:add, PMID:16464608, PMID:17306522, ISBN:0781765196] synonym: "pre-BCR" EXACT is_a: GO:0044425 ! membrane part is_a: GO:0043234 ! protein complex

Notes to GO editors about term placement for "pre-BCR": Despite the word receptor in its name, the pre-BCR is not a receptor complex, as it appears to simply provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. Thus the pre-BCR is a "protein complex" rather than a "receptor complex".

Also, a significant proportion of pre-BCR complexes fail to reach the cell surface, and may rather provide their signaling function from the trans-golgi network in some cases or lysosome. Thus, the pre-BCR is a "membrane part" rather a "plasma membrane part".

Thanks,

Alex (CL)

Reported by: addiehl

Original Ticket: geneontology/ontology-requests/7181

gocentral commented 14 years ago

Original comment by: mah11

gocentral commented 14 years ago

Added in new term: pre-B cell receptor complex ; GO:00035369

Thanks for the placement notes... I've also added them to the comment section for the term so it doesn't get moved inappropriately later on. Also tweaked the definition ever so slightly since it's not always in the plasma membrane: 'An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells.....'

Everything else is exactly as you suggested. Thanks, Becky

Original comment by: rebeccafoulger

gocentral commented 14 years ago

Original comment by: rebeccafoulger

gocentral commented 14 years ago

Thanks Becky for entering the term and fixing the definition.

-- Alex

Original comment by: addiehl