obsolete GO:0030400?

[gocentral]

Here's another term that really needs some work:

protease substrate recruitment factor activity ; GO:0030400

def: A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity. ref: PMID:11500370

Probably the best thing to do is make this term obsolete, because the definition is that of a gene product, and the term isn't that great as a description of an activity. There's only one gene product annotated to it (product of S. cerevisiae CIC1, described in the paper cited for the definition).

Reported by: mah11

Original Ticket: "geneontology/ontology-requests/748":https://sourceforge.net/p/geneontology/ontology-requests/748

[gocentral]

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To do along with obsoleting GO:0030400

add a new term -- %binding ; GO:0005488 --- %protein binding ; GO:0005515 ---- %protein binding, bridging ; GO:new

definition: Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex simultaneously, thereby physically linking the bound proteins or complexes to each other.

Original comment by: mah11

[gocentral]

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Comments from email:

How about:

%binding ; GO:0005488 %protein binding ; GO:0005515 %protein binding, bridging ; GO:new

definition: Interacting selectively with two or more protein molecules simultaneously, thereby physically linking the bound proteins (or protein complexes) to each other.

Comments on the term and definition welcome. Midori

On Thu, 10 Apr 2003, Rama Balakrishnan wrote:

> Hi Midori, > > I looked at the term and I agree the term is gene product specific. we > can obsolete it. > But i looked at the paper again and I felt that a general term like > 'adaptor molecule activity or bridging activity or recruiting activity' > could describe the function of this gene product. We don't have this > term right now (or I couldn't find it) > and I can solicit comments/opinions to create this term. > I could settle for annotating this gene product (CIC1) to protein > binding (although > it binds to the protein complex). > Please let me know what you think. > > Thanks, > > Rama

Original comment by: mah11

[gocentral]

• status: open --> closed-fixed

Original comment by: mah11

[gocentral]

Logged In: YES user_id=436423

GO:0030400 made obsolete.

Added new term as described, with a slight edit to the def. term: protein binding, bridging goid: GO:0030674 definition: Interacting selectively with two or more protein molecules, or a protein and another macromelecule or complex simultaneously, thereby physically linking the bound proteins or complexes to each other. definition_reference: GO:mah

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Original comment by: mah11