Are all promoters double-stranded DNA?

geneontology / go-ontology

Source ontology files for the Gene Ontology

http://geneontology.org/page/download-ontology

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Are all promoters double-stranded DNA? #7555

Closed gocentral closed 9 years ago

gocentral commented 14 years ago

Should either GO:0010843 "promoter binding" or GO:0044212 "DNA regulatory region binding" be a child of GO:0003690 "double-stranded DNA binding" instead of just GO:0003677 "DNA binding"?

(Submitted while curating PTHR11829 using PAINT)

Reported by: livstone

Original Ticket: geneontology/ontology-requests/7337

gocentral commented 14 years ago

Hi Mike,

According to PMID:12538860 (A single-stranded promoter for RNA polymerase III), single-stranded DNA promoters are rare, but they do exist.

Becky

Original comment by: rebeccafoulger

gocentral commented 14 years ago

Good to know. Thanks!

-Mike

Original comment by: livstone

gocentral commented 14 years ago

status: open --> closed-rejected

Original comment by: livstone

gocentral commented 14 years ago

There are viruses with single stranded genomes, so I wouldn't want to make this change, as proposed, without understand viral transcription better.

-Karen

Original comment by: krchristie