SIG_MTG: RG NTR: -ive regulation of PI3K/Akt Signaling

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Hi,

Please may I request a new term for annotation of Klf4 (Q923V7) in PMID:19531492 (IMP) PI3K / Akt signaling pathway GO:NEW --<regulation of PI3K / Akt signaling pathway GO:NEW --<negative regulation of PI3K / Akt signaling pathway GO:NEW

Thanks, Yasmin

Reported by: yafaruque

Original Ticket: geneontology/ontology-requests/7419

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Also need positive regulation of PI3K / Akt signaling pathway GO:NEW for annotation of RAR-alpha (Q499N1) (IMP) thanks, Y

Original comment by: yafaruque

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• assigned_to: nobody --> tairtb

Original comment by: jl242

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Hi Yasmin,

I found the following term in GO:

GO:0043491, protein kinase B signaling EXACT SYNONYM: AKT signaling cascade Definition: A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound.

Could that be what you are seeking?

If your process is different, can you provide a definition for the signaling pathway please? You can consult with Becky on the current structure of the signaling branch of the ontology and how such terms are currently defined so that the new term will be consistent with the existing ones. Also, placement within the existing structure would be great.

You know, I think I will reassign this item to Becky so that she can give it the full treatment as she has much more background in the signaling area of GO than I do.

Becky: :) Hope you don't mind. If you like, you can reassign this to me after the main process term is in and I will add the regulation terms.

Thanks very much,

Tanya

Original comment by: tberardini

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• assigned_to: tairtb --> rfoulger

Original comment by: tberardini

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Hi Tanya,

I think the PI3K/Akt signaling pathway is different to that of GO:0043491 protein kinase B signaling, as this one is a retinoid-activated pathway involving the lipid kinase phosphatidylinositol 3-kinase (PI3K). There is detailed information about this pathway at http://rgd.mcw.edu/wg/pathway/phosphatidylinositol\_3-kinase-akt\_signaling\_pathway. [term]: Phosphatidylinositol 3-kinase-Akt signaling pathway [definition]: Phosphatidylinositol 3-kinase-Akt signaling pathway plays a crucial role in many important cellular processes. PI3K-Akt pathway is one of the two conduits of insulin signaling. Also, PI3K-Akt pathway, possibly via Akt2, is believed to play a role in the insulin responsive glucose transport. PI3K-Akt plays a central role in activating mTOR pathway by removing the inhibitory effect exerted upon the mTorc1 complex of mTOR. mTOR signaling controls protein translation and ribosome biogenesis, among others. In addition, PI3K-Akt exerts an inhibitory effect upon the forkhead pathway (FoxO subgroup) and promotes cell survival (FoxO transcription factors are target genes). [syn] PI3K/Akt signaling pathway

I will also liase with Becky when she is back from honeymoon. Thanks, Yasmin.

Original comment by: yafaruque

[gocentral]

Hi Yasmin and Tanya,

AKT and PKB (protein kinase B) are the same thing. In many pathways (eg insulin receptor signaling), PI3K acts upstream of AKT/PKB to activate it. AKT/PKB can also be activated by PI3K-independent routes too though.

I agree with Tanya that the best existing terms to annotate to are GO:0043491, protein kinase B signaling and also to GO:0014065 phosphoinositide 3-kinase cascade (or their regulation children)

I'll have a think about how we can link up the two (PI3K and PKB/AKT that is).

We discussed in the signaling group adding in terms to connect the intracellular signaling cassettes to the upstream receptors, so I can add terms for 'PKB pathway involved in retinoic acid receptor signaling'. We're still resolving the exact wording of these terms so I'll take a proper look after the GO camp.

thanks, Becky

Original comment by: rebeccafoulger

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Hi Becky,

Thanks for the confirmation on the pathway. I shall annotate using the terms that are already available,

Yasmin

Original comment by: yafaruque

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• summary: RG NTR: -ive regulation of PI3K / Akt Signaling pathway --> SIG_MTG: RG NTR: -ive regulation of PI3K/Akt Signaling

Original comment by: rebeccafoulger

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See signaling wiki:

http://gocwiki.geneontology.org/index.php/Cascades

Original comment by: jl242

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• labels: 390929 --> signaling
• status: open --> closed-invalid

Original comment by: jl242