gocentral
commented
14 years ago From John Garavelli:
"Most protein glycosylations are "post-translational" but some are "co-translational". It depends on many factors and any definition may not hold across taxa. I have said several times that "post-translational modification" is not a useful or even a usable term for ontological classification, because people say PTM or "post-translational modification" when they really have no idea whether a particular modification, including many glycosylations, are post- or co- translational. It should be dropped as a term making a meaningless distinction. You may want to make post-translational modification and co-translational modification children of protein modification and then slap strong caution comments on them that experimental evidence of whether a particular modification is one or the other is usually not available and may not be consistently true, and then both should be sterilized (not allowed to have any children). Only "pre-translational" has a consistent operational definition, and no one but me likes to use it.
As put in MP protein amino-acid glycosylation - ID: 3021391, a glycosylation IS_A type of protein (spelling!) modification, and I really wish the "post-translational" were removed altogether, otherwise the definition can sometimes be invalid."
Original comment by: jl242
as we have the term "post-translational protin modification" it should be a parent of protein amino-acid glycosylation, I think
(is the term "post-translational protin modification" ? I'm not sure?)
Reported by: ValWood
Original Ticket: geneontology/ontology-requests/7494