SIG_MTG: non-canonical Wnt signaling pathway

[gocentral]

Hi,

I would like to annotate WNT5A to the new term

NT: not sure how to name this (it should be a sibling of GO:0060070 Wnt receptor signaling pathway through beta-catenin) Defn: The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes, but that does not signal through beta-catenin. is_a: GO:0016055 Wnt receptor signaling pathway syn: noncanonical Wnt signaling pathway syn: non-canonical Wnt signaling pathway

Possibly the other children of GO:0016055 Wnt receptor signaling pathway would then need to be grouped under the canonical and non-canonical terms as appropriate. Have set as high priority, as the quicker this can be resolved the easier it will be annotate the rest of this pathway.

Thanks, V

Reported by: vkhodiyar

Original Ticket: geneontology/ontology-requests/7502

[gocentral]

As discussed on the email thread, I'm happy with the canonical and non-canonical names if you want to change them Becky.

Original comment by: jl242

[gocentral]

• assigned_to: nobody --> rfoulger

Original comment by: jl242

[gocentral]

Hi

in PMID: 20032469 WNT5A signaling through JNK is demonstrated, however the experiment has not shown GO:0060071 Wnt receptor signaling pathway, planar cell polarity pathway. but just transcriptional regulation via JNK.

Is this term going to be just too complex: Regulation of transcription via Wnt receptor mediated activation of the JNK signaling pathway Definition: The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via C-Jun N-terminal kinase (JNK) downstream effectors to modulate transcription.

Parents: GO:0046330 positive regulation of JNK cascade GO:0016055 Wnt receptor signaling pathway GO:0045449 regulation of transcription

Original comment by: RLovering

[gocentral]

Another non-canonical pathway for you - PMID:17720811 describes the induction of the p38 (MAPK) pathway via noncanonical WNT signaling.

For annotation of WNT4.

Thanks, V

Original comment by: vkhodiyar

[gocentral]

Renamed Wnt receptor signaling pathway through beta-catenin ; GO:0060070 > canonical Wnt receptor signaling pathway exact synonym:Wnt receptor signaling pathway through beta-catenin

renamed children accordingly.

Created new term: non-canonical Wnt receptor signaling pathway ; GO:0035567 The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. Comment: This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term.

will crack on with the via/involved in terms .... Becky

Original comment by: rebeccafoulger

[gocentral]

Hi

wrt JNK signaling, I am annotating PMID:19137009 which shows that FZD10 affects JNK activity, and cytoskeleton organisation, but not planar cell polarity.

Please could you create the term:Wnt receptor signaling, via JNK pathway GO:0035567 non-canonical Wnt receptor signaling pathway > New term: Wnt receptor signaling, via JNK pathway >> GO:0060071 Wnt receptor signaling pathway, planar cell polarity pathway

Thanks

Ruth

Original comment by: RLovering

[gocentral]

Hi please also create terms: negative regulation of Wnt receptor signaling, via JNK pathway negative regulation of non-canonical Wnt receptor signaling pathway

for annotation of xenopus SFRP5 Q8AWG4 IMP PMID:18981481

Thanks

Ruth

Original comment by: RLovering

[gocentral]

• summary: non-canonical Wnt signaling pathway --> SIG_MTG: non-canonical Wnt signaling pathway

Original comment by: rebeccafoulger

[gocentral]

• labels: 390929 --> signaling
• status: open --> pending

Original comment by: rebeccafoulger

[gocentral]

see wiki: http://wiki.geneontology.org/index.php/Cascades

Original comment by: rebeccafoulger

[gocentral]

In keeping with the cascade work, created new terms:

non-canonical Wnt receptor signaling pathway via MAPKKK cascade ; GO:0038030

non-canonical Wnt receptor signaling pathway via JNK cascade ; GO:0038031

This should wrap-up this SF item. Thanks Becky

And we already have: negative regulation of non-canonical Wnt receptor signaling pathway ; GO:2000051

Original comment by: rebeccafoulger

[gocentral]

• status: pending --> closed-fixed

Original comment by: rebeccafoulger