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Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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RG NTR: -ive rgn of can Wnt sig pthwy in panc B cell prolifn #7875

Closed gocentral closed 9 years ago

gocentral commented 14 years ago

Hi,

Please may I request the following new terms for annotation of Wnt3a_mouse (P27467 ) and SFRP1_human (Q8N474) in PMID:17994217

GO:0003323 pancreatic B cell development --<pancreatic B cell proliferation GO:NEW --<regulation of pancreatic B cell proliferation GO:NEW --< positive regulation of pancreatic B cell proliferation GO:NEW (IDA for Wnt3a_m) --< negative regulation of pancreatic B cell proliferation GO:NEW (IDA for SFRP1_h)

GO:0060070 canonical Wnt receptor signaling pathway --<canonical Wnt receptor signaling pathway involved in cell proliferation GO:NEW --<canonical Wnt receptor signaling pathway involved in pancreatic B cell proliferation GO:NEW --<regulation of canonical Wnt receptor signaling pathway involved in pancreatic B cell proliferation GO:NEW --<positive regulation of regulation of canonical Wnt receptor signaling pathway involved in pancreatic B cell proliferation GO:NEW (IDA for Wnt3a_m) --<negative regulation of canonical Wnt receptor signaling pathway involved in pancreatic B cell proliferation GO:NEW (IDA for SFRP1_h)

Thanks, Yasmin.

Reported by: yafaruque

Original Ticket: geneontology/ontology-requests/7659

gocentral commented 14 years ago

Original comment by: yafaruque

gocentral commented 14 years ago

Added:

pancreatic B cell proliferation ; GO:0044342 (as child of 'cell proliferation though, not 'pancreatic B cell development').

We already have 'canonical Wnt receptor signaling pathway involved in cell proliferation ; GO:0044340'

Also added:

canonical Wnt receptor signaling pathway involved in pancreatic B cell proliferation ; GO:0044343

Original comment by: jl242

gocentral commented 14 years ago

Original comment by: jl242

gocentral commented 14 years ago

Hi Jane,

Was trolling for regulation terms to add using the xp form and found this, so I've gone ahead and added:

id: GO:2000074 name: negative regulation of pancreatic B cell development

id: GO:2000077 name: negative regulation of pancreatic B cell development

id: GO:2000078 name: positive regulation of pancreatic B cell development

id: GO:2000079 name: regulation of canonical Wnt receptor signaling pathway involved in pancreatic B cell proliferation

id: GO:2000080 name: negative regulation of canonical Wnt receptor signaling pathway involved in pancreatic B cell proliferation

id: GO:2000081 name: positive regulation of canonical Wnt receptor signaling pathway involved in pancreatic B cell proliferation

Will commit the terms to the live ontology on Monday pm, CA time as I won't be at work anymore when the cvs file for the xp_submit directory updates next.

Original comment by: tberardini

gocentral commented 14 years ago

Original comment by: tberardini

gocentral commented 14 years ago

Regulation terms are in. I think that covers it.

Original comment by: tberardini

gocentral commented 14 years ago

Original comment by: tberardini

gocentral commented 14 years ago

Hi Tanya, it looks like you've added 2 negative regulation terms i.e id: GO:2000074 name: negative regulation of pancreatic B cell development

id: GO:2000077 name: negative regulation of pancreatic B cell development

and I think maybe one of them should just be 'regulation of pancreatic B cell development'?

thanks, Yasmin

Original comment by: yafaruque